High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways DOI Creative Commons
Joshua M. Peters, Edward B. Irvine, Mohau S. Makatsa

и другие.

Science Advances, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 1, 2025

Intradermal Bacillus Calmette-Guérin (BCG) is the most widely administered vaccine, but it does not sufficiently protect adults against pulmonary tuberculosis. Recent studies in nonhuman primates show that intravenous BCG administration offers superior protection Mycobacterium tuberculosis ( Mtb ). We used single-cell analysis of bronchoalveolar lavage cells from rhesus macaques vaccinated via different routes and doses to identify alterations immune ecosystem airway following vaccination. Our findings reveal high-dose induces an influx polyfunctional T macrophages airways, with alveolar displaying a basal activation state absence purified protein derivative stimulation, defined part by interferon signaling. Enhanced intercellular signaling stronger helper 1–T 17 transcriptional responses were observed stimulation. These results suggest vaccination creates specialized environment primes for effective clearance.

Язык: Английский

High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways DOI Creative Commons
Joshua M. Peters, Edward B. Irvine, Mohau S. Makatsa

и другие.

Science Advances, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 1, 2025

Intradermal Bacillus Calmette-Guérin (BCG) is the most widely administered vaccine, but it does not sufficiently protect adults against pulmonary tuberculosis. Recent studies in nonhuman primates show that intravenous BCG administration offers superior protection Mycobacterium tuberculosis ( Mtb ). We used single-cell analysis of bronchoalveolar lavage cells from rhesus macaques vaccinated via different routes and doses to identify alterations immune ecosystem airway following vaccination. Our findings reveal high-dose induces an influx polyfunctional T macrophages airways, with alveolar displaying a basal activation state absence purified protein derivative stimulation, defined part by interferon signaling. Enhanced intercellular signaling stronger helper 1–T 17 transcriptional responses were observed stimulation. These results suggest vaccination creates specialized environment primes for effective clearance.

Язык: Английский

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