Cell and Tissue Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 10, 2024
Abstract This review briefly summarizes 50 years of research on insect neuropeptide and peptide hormone (collectively abbreviated NPH) signaling, starting with the sequencing proctolin in 1975. The first 25 years, before Drosophila genome, were characterized by efforts to identify novel NPHs biochemical means, mapping their distribution neurons, neurosecretory cells, endocrine cells intestine. Functional studies predominantly dealing hormonal aspects peptides many employed ex vivo assays. With annotation more specifically receptors other insects, a new era followed. started matching NPH ligands orphan receptors, localize improved detection methods. Important advances made introduction rich repertoire innovative molecular genetic approaches interfere expression or function receptors. These methods enabled cell- circuit-specific interference signaling for assays determine roles behavior physiology, imaging neuronal activity, analysis connectivity peptidergic circuits. Recent have seen dramatic increase reports multiple functions development, physiology behavior. Importantly, we can now appreciate pleiotropic NPHs, as well functional “networks” where state dependent ensures behavioral plasticity systemic homeostasis.
Язык: Английский