Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts DOI Creative Commons

Raymond Nicks,

Arsal Shah,

Spiro Anthony Stathas

и другие.

Acta Neuropathologica, Год журнала: 2024, Номер 148(1)

Опубликована: Дек. 6, 2024

Abstract Neurodegeneration is a seminal feature of many neurological disorders. Chronic traumatic encephalopathy (CTE) caused by repetitive head impacts (RHI) and characterized sulcal tau pathology. However, quantitative assessments regional neurodegeneration in CTE have not been described. In this study, we quantified three key neurodegenerative measures, including cortical thickness, neuronal density, synaptic proteins, contact sport athletes ( n = 185) non-athlete controls 52) within the depth, middle, gyral crest dorsolateral frontal cortex. Cortical thickness density were decreased sulcus compared to p ’s < 0.05). Measurements proteins showed reduction α-synuclein with stage 0.002) variable changes PSD-95 density. After adjusting for age, multiple linear regression models demonstrated strong association between duration sports play thinning 0.001) loss 0.032) sulcus. Additional models, adjusted pathology, suggest that sulcus, was associated predominantly through contrast, minimally impacted Overall, atrophy predominant neurodegeneration. Furthermore, measures are more severe may occur tau-dependent independent mechanisms.

Язык: Английский

Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts DOI Creative Commons

Raymond Nicks,

Arsal Shah,

Spiro Anthony Stathas

и другие.

Acta Neuropathologica, Год журнала: 2024, Номер 148(1)

Опубликована: Дек. 6, 2024

Abstract Neurodegeneration is a seminal feature of many neurological disorders. Chronic traumatic encephalopathy (CTE) caused by repetitive head impacts (RHI) and characterized sulcal tau pathology. However, quantitative assessments regional neurodegeneration in CTE have not been described. In this study, we quantified three key neurodegenerative measures, including cortical thickness, neuronal density, synaptic proteins, contact sport athletes ( n = 185) non-athlete controls 52) within the depth, middle, gyral crest dorsolateral frontal cortex. Cortical thickness density were decreased sulcus compared to p ’s < 0.05). Measurements proteins showed reduction α-synuclein with stage 0.002) variable changes PSD-95 density. After adjusting for age, multiple linear regression models demonstrated strong association between duration sports play thinning 0.001) loss 0.032) sulcus. Additional models, adjusted pathology, suggest that sulcus, was associated predominantly through contrast, minimally impacted Overall, atrophy predominant neurodegeneration. Furthermore, measures are more severe may occur tau-dependent independent mechanisms.

Язык: Английский

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