SUN-domain proteins of the malaria parasite Plasmodium falciparum are essential for proper nuclear division and DNA repair DOI Creative Commons

Sofiya Kandelis-Shalev,

Manish Goyal,

Tal Elam

и другие.

mBio, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

The protozoan parasite Plasmodium falciparum, which is responsible for the deadliest form of human malaria, accounts over half a million deaths year. These parasites proliferate in red blood cells by consecutive rounds closed mitoses called schizogony. Their virulence attributed to their ability modify infected adhere vascular endothelium and evade immunity through antigenic switches. Spatial dynamics at nuclear periphery were associated with regulation processes that enable establish long-term infection. However, our knowledge components envelope (NE) remains limited. One major protein complexes NE linker nucleoskeleton cytoskeleton (LINC) complex forms connecting bridge between cytoplasm nucleus interaction SUN KASH domain proteins. Here, we have identified two SUN-domain proteins as possible LINC P. falciparum show proper expression essential parasite's proliferation cells, depletion leads formation membranous whorls morphological changes NE. In addition, differential highlights different functions PfSUN2 specifically heterochromatin, while PfSUN1 activation DNA damage response. Our data provide indications involvement crucial biological intraerythrocytic development cycle malaria parasites. causing able thrive its host tight cellular processes, orchestrating cytoplasmic machineries are separated envelope. connect eukaryotes complex. was implicated several important functions, role biology unknown. identify demonstrate they parasites' blood, cell. activating response association heterochromatin. evidence roles cell cycle.

Язык: Английский

Genome-scale, functional screen of Plasmodium sexual replication DOI
Surendra K. Prajapati, Kim C. Williamson

Trends in Parasitology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
SUN-domain proteins of the malaria parasite Plasmodium falciparum are essential for proper nuclear division and DNA repair DOI Creative Commons

Sofiya Kandelis-Shalev,

Manish Goyal,

Tal Elam

и другие.

mBio, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

The protozoan parasite Plasmodium falciparum, which is responsible for the deadliest form of human malaria, accounts over half a million deaths year. These parasites proliferate in red blood cells by consecutive rounds closed mitoses called schizogony. Their virulence attributed to their ability modify infected adhere vascular endothelium and evade immunity through antigenic switches. Spatial dynamics at nuclear periphery were associated with regulation processes that enable establish long-term infection. However, our knowledge components envelope (NE) remains limited. One major protein complexes NE linker nucleoskeleton cytoskeleton (LINC) complex forms connecting bridge between cytoplasm nucleus interaction SUN KASH domain proteins. Here, we have identified two SUN-domain proteins as possible LINC P. falciparum show proper expression essential parasite's proliferation cells, depletion leads formation membranous whorls morphological changes NE. In addition, differential highlights different functions PfSUN2 specifically heterochromatin, while PfSUN1 activation DNA damage response. Our data provide indications involvement crucial biological intraerythrocytic development cycle malaria parasites. causing able thrive its host tight cellular processes, orchestrating cytoplasmic machineries are separated envelope. connect eukaryotes complex. was implicated several important functions, role biology unknown. identify demonstrate they parasites' blood, cell. activating response association heterochromatin. evidence roles cell cycle.

Язык: Английский

Процитировано

0