Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations DOI Open Access
Cecilia Monge,

Brigette Waldrup,

Francisco Carranza

и другие.

Cancers, Год журнала: 2025, Номер 17(8), С. 1325 - 1325

Опубликована: Апрель 15, 2025

Background/Objectives: The incidence of early-onset colorectal cancer (EOCRC), defined as diagnosis before age 50, has been rising at an alarming rate, with Hispanic/Latino (H/L) individuals experiencing the most significant increases in both and mortality. Despite this growing public health concern, molecular mechanisms driving EOCRC disparities remain poorly understood. Oncogenic pathways such WNT, TGF-beta, RTK/RAS are critical (CRC) progression, yet their specific roles across diverse populations have not extensively studied. This research seeks to identify alterations within these by comparing cases H/L non-Hispanic White (NHW) individuals. Furthermore, we explore clinical significance findings inform precision medicine strategies tailored high-risk populations. Methods: To investigate mutation frequencies genes associated pathways, conducted a bioinformatics analysis using publicly available CRC datasets. study cohort consisted 3412 patients, including 302 3110 NHW patients were categorized based on (EOCRC: <50 years; late-onset [LOCRC]: ≥50 years) population group (H/L vs. NHW) assess variations prevalence. Statistical comparisons rates between groups chi-squared tests, while Kaplan–Meier survival was employed evaluate overall differences pathway alterations. Results: Notable distinctions identified LOCRC among exhibiting lower frequency compared (66.7% 79.3%, p = 0.01). Within pathway, mutations CBL (p < 0.05) NF1 significantly more prevalent (5.8% 1.2% 11.6% 3.7%, respectively), whereas BRAF notably less frequent than (5.1% 18.3%, 0.05). Comparisons from revealed distinct pathway-specific that common These included RNF43 (12.3% 6.7%, WNT BMPR1A 1.8%, TGF-beta multiple alterations, MAPK3 (3.6% 0.7%, 0.05), 1.4%, (11.6% 6.1%, Survival did reveal statistically However, presence improved outcomes, suggesting potential ethnicity-specific prognostic implications. Conclusions: highlights substantial heterogeneity present EOCRC, particularly exhibited genetic higher prevalence CBL, NF1, RNF43, BMPR1A, counterparts. Additionally, LOCRC. differences, impact outcomes patients. survival. emphasize necessity for further clarify underrepresented groups.

Язык: Английский

Comparative Genomic Analysis of Key Oncogenic Pathways in Hepatocellular Carcinoma Among Diverse Populations DOI Open Access
Cecilia Monge,

Brigette Waldrup,

Francisco Carranza

и другие.

Cancers, Год журнала: 2025, Номер 17(8), С. 1309 - 1309

Опубликована: Апрель 13, 2025

Background/Objectives: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with significant racial and ethnic disparities in incidence, tumor biology, clinical outcomes. Hispanic/Latino (H/L) patients tend to be diagnosed at younger ages more advanced stages than Non-Hispanic White (NHW) patients, yet the molecular mechanisms underlying these remain poorly understood. Key oncogenic pathways, including RTK/RAS, TGF-beta, WNT, PI3K, TP53, play pivotal roles progression, treatment resistance, response targeted therapies. However, ethnicity-specific alterations within pathways largely unexplored. This study aims compare pathway-specific mutations HCC between H/L NHW assess mutation burden, identify ethnicity-associated drivers using publicly available datasets. Findings from this analysis may inform precision medicine strategies for improving early detection therapies underrepresented populations. Methods: We conducted bioinformatic datasets frequencies TP53 pathway genes. included 547 consisting 69 478 patients. Patients were stratified by ethnicity (H/L vs. NHW) evaluate differences prevalence. Chi-squared tests used frequencies, while Kaplan–Meier survival assessed overall associated both Results: Significant observed RTK/RAS pathway-related genes, particularly FGFR4 mutations, which prevalent compared (4.3% 0.6%, p = 0.02). Additionally, IGF1R exhibited borderline significance (7.2% 2.9%, 0.07). In PI3K pathway, INPP4B frequent 1%, 0.06), while, TGF-beta TGFBR2 common (2.9% 0.4%, 0.07), suggesting potential variations. Survival revealed no indicating that alone not fully explain role additional factors such as immune response, environmental exposures, or access Conclusions: provides one first ethnicity-focused analyses key HCC, revealing distinct The findings suggest (FGFR4, IGF1R), (INPP4B), (TGFBR2) among their prognostic remains unclear. These insights emphasize importance incorporating profiling into approaches improve detection, therapies, outcomes

Язык: Английский

Процитировано

0
Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations DOI Open Access
Cecilia Monge,

Brigette Waldrup,

Francisco Carranza

и другие.

Cancers, Год журнала: 2025, Номер 17(8), С. 1325 - 1325

Опубликована: Апрель 15, 2025

Background/Objectives: The incidence of early-onset colorectal cancer (EOCRC), defined as diagnosis before age 50, has been rising at an alarming rate, with Hispanic/Latino (H/L) individuals experiencing the most significant increases in both and mortality. Despite this growing public health concern, molecular mechanisms driving EOCRC disparities remain poorly understood. Oncogenic pathways such WNT, TGF-beta, RTK/RAS are critical (CRC) progression, yet their specific roles across diverse populations have not extensively studied. This research seeks to identify alterations within these by comparing cases H/L non-Hispanic White (NHW) individuals. Furthermore, we explore clinical significance findings inform precision medicine strategies tailored high-risk populations. Methods: To investigate mutation frequencies genes associated pathways, conducted a bioinformatics analysis using publicly available CRC datasets. study cohort consisted 3412 patients, including 302 3110 NHW patients were categorized based on (EOCRC: <50 years; late-onset [LOCRC]: ≥50 years) population group (H/L vs. NHW) assess variations prevalence. Statistical comparisons rates between groups chi-squared tests, while Kaplan–Meier survival was employed evaluate overall differences pathway alterations. Results: Notable distinctions identified LOCRC among exhibiting lower frequency compared (66.7% 79.3%, p = 0.01). Within pathway, mutations CBL (p < 0.05) NF1 significantly more prevalent (5.8% 1.2% 11.6% 3.7%, respectively), whereas BRAF notably less frequent than (5.1% 18.3%, 0.05). Comparisons from revealed distinct pathway-specific that common These included RNF43 (12.3% 6.7%, WNT BMPR1A 1.8%, TGF-beta multiple alterations, MAPK3 (3.6% 0.7%, 0.05), 1.4%, (11.6% 6.1%, Survival did reveal statistically However, presence improved outcomes, suggesting potential ethnicity-specific prognostic implications. Conclusions: highlights substantial heterogeneity present EOCRC, particularly exhibited genetic higher prevalence CBL, NF1, RNF43, BMPR1A, counterparts. Additionally, LOCRC. differences, impact outcomes patients. survival. emphasize necessity for further clarify underrepresented groups.

Язык: Английский

Процитировано

0