Characterizing the Rates and Patterns of De Novo Germline Mutations in the Aye-Aye (Daubentonia madagascariensis) DOI Creative Commons
Cyril J. Versoza, Erin E. Ehmke, Jeffrey D. Jensen

и другие.

Molecular Biology and Evolution, Год журнала: 2025, Номер 42(3)

Опубликована: Март 1, 2025

Given the many levels of biological variation in mutation rates observed to date primates-spanning from species individuals genomic regions-future steps our understanding rate evolution will not only be aided by a greater breadth coverage across primate clade but also depth as afforded an evaluation multiple trios within individual species. In order help bridge these gaps, we here present analysis representing one most basal splits on tree (aye-ayes), combining whole-genome sequencing seven parent-offspring three-generation pedigree with novel computational pipeline that takes advantage recently developed pan-genome graphs, thereby circumventing application (highly subjective) quality metrics has previously been shown result notable differences detection de novo mutations and ultimately estimates rates. This deep sampling enabled both detailed picture parental age effects sex dependency rates, which compare studied primates, provided unique insights into nature genetic endangered primates planet.

Язык: Английский

Estimating the distribution of fitness effects in aye-ayes (Daubentonia madagascariensis), accounting for population history as well as mutation and recombination rate heterogeneity DOI Open Access
Vivak Soni, Cyril J. Versoza, Susanne P. Pfeifer

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

ABSTRACT The distribution of fitness effects (DFE) characterizes the range selection coefficients from which new mutations are sampled, and thus holds a fundamentally important role in evolutionary genomics. To date, DFE inference primates has been largely restricted to haplorrhines, with limited data availability leaving other suborder primates, strepsirrhines, under-explored. advance our understanding population genetics this taxonomic group, we here map exonic divergence aye-ayes ( Daubentonia madagascariensis ) – only extant member Daubentoniidae family Strepsirrhini suborder. We further infer highly-endangered species, utilizing recently published high-quality annotated reference genome, well-supported model demographic history, as well both direct indirect estimates underlying mutation recombination rates. inferred is generally characterized by greater proportion deleterious relative humans, providing evidence larger long-term effective size. In addition however, immune-related sensory-related genes were found be amongst most rapidly evolving aye-aye genome.

Язык: Английский

Процитировано

1
Characterizing the Rates and Patterns of De Novo Germline Mutations in the Aye-Aye (Daubentonia madagascariensis) DOI Creative Commons
Cyril J. Versoza, Erin E. Ehmke, Jeffrey D. Jensen

и другие.

Molecular Biology and Evolution, Год журнала: 2025, Номер 42(3)

Опубликована: Март 1, 2025

Given the many levels of biological variation in mutation rates observed to date primates-spanning from species individuals genomic regions-future steps our understanding rate evolution will not only be aided by a greater breadth coverage across primate clade but also depth as afforded an evaluation multiple trios within individual species. In order help bridge these gaps, we here present analysis representing one most basal splits on tree (aye-ayes), combining whole-genome sequencing seven parent-offspring three-generation pedigree with novel computational pipeline that takes advantage recently developed pan-genome graphs, thereby circumventing application (highly subjective) quality metrics has previously been shown result notable differences detection de novo mutations and ultimately estimates rates. This deep sampling enabled both detailed picture parental age effects sex dependency rates, which compare studied primates, provided unique insights into nature genetic endangered primates planet.

Язык: Английский

Процитировано

1