Ontogeny of the spinal cord dorsal horn DOI Creative Commons
R. Brian Roome, Archana Yadav,

Lydia Flores

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 15, 2025

Summary The dorsal horn of the mammalian spinal cord is an exquisite example form serving function. It comprised diverse neuronal populations stacked into laminae, each which receives different circuit connections and plays specialized roles in behavior. An outstanding question how this organization emerges during development from apparently homogeneous pool neural progenitors. Here, we found that neurons are diversified by time, with families related cell types born as temporal cohorts, a spatial-molecular gradient specifies full array individual types. Excitatory then settle chronotopic arrangement transforms their progressive birthdates anatomical order. This establishes these also required for spatial inhibitory sensory axons. work reveals essential ontogenetic principles shape progenitors architecture subserve sensorimotor Highlights - Temporal cohorts late-born give rise to Sequentially-born excitatory neuron adjacent laminae Laminar structure specifically requires (but not or sensory) Graded expression Zic transcription factors directs fine identity

Язык: Английский

Ontogeny of the spinal cord dorsal horn DOI Creative Commons
R. Brian Roome, Archana Yadav,

Lydia Flores

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 15, 2025

Summary The dorsal horn of the mammalian spinal cord is an exquisite example form serving function. It comprised diverse neuronal populations stacked into laminae, each which receives different circuit connections and plays specialized roles in behavior. An outstanding question how this organization emerges during development from apparently homogeneous pool neural progenitors. Here, we found that neurons are diversified by time, with families related cell types born as temporal cohorts, a spatial-molecular gradient specifies full array individual types. Excitatory then settle chronotopic arrangement transforms their progressive birthdates anatomical order. This establishes these also required for spatial inhibitory sensory axons. work reveals essential ontogenetic principles shape progenitors architecture subserve sensorimotor Highlights - Temporal cohorts late-born give rise to Sequentially-born excitatory neuron adjacent laminae Laminar structure specifically requires (but not or sensory) Graded expression Zic transcription factors directs fine identity

Язык: Английский

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