The use of race and ethnicity in sickle cell disease research DOI Creative Commons
Aida S. Kidane Gebremeskel, Minke A.E. Rab, Erik van Werkhoven

и другие.

BMC Medical Research Methodology, Год журнала: 2025, Номер 25(1)

Опубликована: Март 7, 2025

This study explores practices surrounding the operationalization of ethno-racial categories (ERCs) as confounders in biomedical research, with a focus on sickle cell disease (SCD) model. ERCs, often aggregate labels encompassing diverse individuals which raises questions about their relevance confounders. Given SCD's racialization "Black" disease, understanding ERC utilization is crucial. analyzed 1,105 SCD studies published globally. Data were collected whether adjustment was employed, regional variations ERC-adjustment rates, used for rationales provided matching, and methods determination. 28% utilized adjustment, significant disparities (p < 0.001). Notably, Western showed higher rates compared to other regions. However, crucial details such methodology frequently missing. Commonly included "African" or "Black." Only 7% explicit 70% did not specify method The findings underscore need adhere guidelines biomedicine. lack standardized concerns potential biases misinterpretations research outcomes. Adhering clear can mitigate risk perpetuating racial stereotypes inequalities while ensuring integrity. Not applicable.

Язык: Английский

The use of race and ethnicity in sickle cell disease research DOI Creative Commons
Aida S. Kidane Gebremeskel, Minke A.E. Rab, Erik van Werkhoven

и другие.

BMC Medical Research Methodology, Год журнала: 2025, Номер 25(1)

Опубликована: Март 7, 2025

This study explores practices surrounding the operationalization of ethno-racial categories (ERCs) as confounders in biomedical research, with a focus on sickle cell disease (SCD) model. ERCs, often aggregate labels encompassing diverse individuals which raises questions about their relevance confounders. Given SCD's racialization "Black" disease, understanding ERC utilization is crucial. analyzed 1,105 SCD studies published globally. Data were collected whether adjustment was employed, regional variations ERC-adjustment rates, used for rationales provided matching, and methods determination. 28% utilized adjustment, significant disparities (p < 0.001). Notably, Western showed higher rates compared to other regions. However, crucial details such methodology frequently missing. Commonly included "African" or "Black." Only 7% explicit 70% did not specify method The findings underscore need adhere guidelines biomedicine. lack standardized concerns potential biases misinterpretations research outcomes. Adhering clear can mitigate risk perpetuating racial stereotypes inequalities while ensuring integrity. Not applicable.

Язык: Английский

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