Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation DOI Creative Commons
Daehan Lee, Michael P. Shahandeh,

Liliane Abuin

и другие.

PLoS Biology, Год журнала: 2025, Номер 23(4), С. e3003120 - e3003120

Опубликована: Апрель 29, 2025

To explore how brains change upon species evolution, we generated single-cell transcriptomic atlases of the central three closely related but ecologically distinct drosophilids: generalists Drosophila melanogaster and simulans , noni fruit specialist sechellia . The global cellular composition these species’ is well-conserved, predicted a few cell types with different frequencies, notably perineurial glia blood–brain barrier, which validate in vivo Gene expression analysis revealed that evolve at rates patterns, glial populations exhibiting greatest divergence between species. Compared to D. brain, gene patterns are more divergent than —despite their similar phylogenetic distance from —indicating specialization reflected structure function its brain. Expression changes include several metabolic signaling genes, suggestive adaptations novel source nutrition. Additional on genes responsive dietary supplement noni, pointing as sites for both physiological genetic adaptation this fruit. Our represent first comparative datasets “whole” provide comprehensive foundation studying evolvability nervous systems well-defined ecological framework.

Язык: Английский

Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation DOI Creative Commons
Daehan Lee, Michael P. Shahandeh,

Liliane Abuin

и другие.

PLoS Biology, Год журнала: 2025, Номер 23(4), С. e3003120 - e3003120

Опубликована: Апрель 29, 2025

To explore how brains change upon species evolution, we generated single-cell transcriptomic atlases of the central three closely related but ecologically distinct drosophilids: generalists Drosophila melanogaster and simulans , noni fruit specialist sechellia . The global cellular composition these species’ is well-conserved, predicted a few cell types with different frequencies, notably perineurial glia blood–brain barrier, which validate in vivo Gene expression analysis revealed that evolve at rates patterns, glial populations exhibiting greatest divergence between species. Compared to D. brain, gene patterns are more divergent than —despite their similar phylogenetic distance from —indicating specialization reflected structure function its brain. Expression changes include several metabolic signaling genes, suggestive adaptations novel source nutrition. Additional on genes responsive dietary supplement noni, pointing as sites for both physiological genetic adaptation this fruit. Our represent first comparative datasets “whole” provide comprehensive foundation studying evolvability nervous systems well-defined ecological framework.

Язык: Английский

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