bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Abstract The cervix functions both as gatekeeper barrier to maintain pregnancy and virtually vanish for birth at term in mammals. period of remodeling well-before is characterized by an inflammatory process associated with reduced cell nuclei density cross-linked collagen, well increased resident macrophages stroma. Contemporarily, progesterone (P4) or near peak concentrations maternal circulation. functional actual loss response P4 thought drive the that enhances uterine contractile activity labor parturition term. objective present study was determine if regulated cytomorphological characteristics prepartum ripening preterm birth. On day 16 pregnancy. Ovaries were removed eliminate main source production a silastic capsule implanted (with vehicle P4, Ovx Ovx+P4, respectively). Controls received vehicle-filled capsule, while into addition group Intact mice ensure sustained throughout (Intact+P4). Pups born controls (days 19-20 postbreeding), but deliveries within 24h (day 17). In Ovx+P4 group, births delayed post-term most Intact+P4 adverse outcomes commonplace. Characteristics degradation collagen advanced compared gave Treatment blocked birth, complicated dystocia. addition, given ovary-intact concentrations, had minimal effects on cytoarchitecture stroma except forestalled dystocia fetal morbidity. Density along area macrophage stain versus postpartum controls. Thus, analyses cellular provided useful biomarkers local inflammation assessment parturition. Collectively, findings suggest responses are part final common mechanism across Summary Loss withdrawal some cytoarchitectural block

Язык: Английский