Review of Collagen I Hydrogels for Bioengineered Tissue Microenvironments: Characterization of Mechanics, Structure, and Transport DOI
Elizabeth E. Antoine, Pavlos P. Vlachos,

Marissa Nichole Rylander

и другие.

Tissue Engineering Part B Reviews, Год журнала: 2014, Номер 20(6), С. 683 - 696

Опубликована: Июнь 13, 2014

Type I collagen hydrogels have been used successfully as three-dimensional substrates for cell culture and shown promise scaffolds engineered tissues tumors. A critical step in the development of viable tissue mimics is quantitative characterization hydrogel properties their correlation with fabrication parameters, which enables to be tuned match specific or fulfill engineering requirements. significant body work has devoted hydrogels; however, due breadth materials techniques characterization, published data are often disjoint hence utility community reduced. This review aims determine parameter space covered by existing identify key gaps literature so that future use research can most efficiently conducted. divided into three sections: (1) relevant parameters introduced several popular methods controlling regulating them described, (2) presented discussed along techniques, (3) state recapitulated directions proposed. Ultimately, this serve a resource selection material methodologies order increase usefulness collagen-hydrogel-based studies experiments.

Язык: Английский

Fibroblasts: Origins, definitions, and functions in health and disease DOI Creative Commons
Maksim V. Plikus, Xiaojie Wang, Sarthak Sinha

и другие.

Cell, Год журнала: 2021, Номер 184(15), С. 3852 - 3872

Опубликована: Июль 1, 2021

Язык: Английский

Процитировано

688

Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering DOI
Hui‐Yuan Wang, Sarah C. Heilshorn

Advanced Materials, Год журнала: 2015, Номер 27(25), С. 3717 - 3736

Опубликована: Май 19, 2015

Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional (3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels, degradation is typically required to allow complex cellular functions occur, leading bulk material degradation. contrast, adaptable are formed by reversible crosslinks. Through breaking re‐formation of the linkages, can be locally modified permit while maintaining their long‐term integrity. addition, these materials biomimetic viscoelastic properties that make them well suited several biotechnology medical applications. this review, an overview adaptable‐hydrogel design considerations linkage selections presented, with focus on various cell‐compatible crosslinking mechanisms exploited form tissue engineering.

Язык: Английский

Процитировано

643

Biology of the Extracellular Matrix DOI Open Access
Jianbo Yue

Journal of Glaucoma, Год журнала: 2014, Номер 23, С. S20 - S23

Опубликована: Янв. 1, 2014

The extracellular matrix (ECM) is an intricate network composed of array multidomain macromolecules organized in a cell/tissue-specific manner. Components the ECM link together to form structurally stable composite, contributing mechanical properties tissues. also reservoir growth factors and bioactive molecules. It highly dynamic entity that vital importance, determining controlling most fundamental behaviors characteristics cells such as proliferation, adhesion, migration, polarity, differentiation, apoptosis.

Язык: Английский

Процитировано

642

Design of biodegradable, implantable devices towards clinical translation DOI
Chunmei Li, Chengchen Guo, Vincent Fitzpatrick

и другие.

Nature Reviews Materials, Год журнала: 2019, Номер 5(1), С. 61 - 81

Опубликована: Дек. 2, 2019

Язык: Английский

Процитировано

630

Review of Collagen I Hydrogels for Bioengineered Tissue Microenvironments: Characterization of Mechanics, Structure, and Transport DOI
Elizabeth E. Antoine, Pavlos P. Vlachos,

Marissa Nichole Rylander

и другие.

Tissue Engineering Part B Reviews, Год журнала: 2014, Номер 20(6), С. 683 - 696

Опубликована: Июнь 13, 2014

Type I collagen hydrogels have been used successfully as three-dimensional substrates for cell culture and shown promise scaffolds engineered tissues tumors. A critical step in the development of viable tissue mimics is quantitative characterization hydrogel properties their correlation with fabrication parameters, which enables to be tuned match specific or fulfill engineering requirements. significant body work has devoted hydrogels; however, due breadth materials techniques characterization, published data are often disjoint hence utility community reduced. This review aims determine parameter space covered by existing identify key gaps literature so that future use research can most efficiently conducted. divided into three sections: (1) relevant parameters introduced several popular methods controlling regulating them described, (2) presented discussed along techniques, (3) state recapitulated directions proposed. Ultimately, this serve a resource selection material methodologies order increase usefulness collagen-hydrogel-based studies experiments.

Язык: Английский

Процитировано

516