Tissue Engineering Part B Reviews,
Год журнала:
2014,
Номер
20(6), С. 683 - 696
Опубликована: Июнь 13, 2014
Type
I
collagen
hydrogels
have
been
used
successfully
as
three-dimensional
substrates
for
cell
culture
and
shown
promise
scaffolds
engineered
tissues
tumors.
A
critical
step
in
the
development
of
viable
tissue
mimics
is
quantitative
characterization
hydrogel
properties
their
correlation
with
fabrication
parameters,
which
enables
to
be
tuned
match
specific
or
fulfill
engineering
requirements.
significant
body
work
has
devoted
hydrogels;
however,
due
breadth
materials
techniques
characterization,
published
data
are
often
disjoint
hence
utility
community
reduced.
This
review
aims
determine
parameter
space
covered
by
existing
identify
key
gaps
literature
so
that
future
use
research
can
most
efficiently
conducted.
divided
into
three
sections:
(1)
relevant
parameters
introduced
several
popular
methods
controlling
regulating
them
described,
(2)
presented
discussed
along
techniques,
(3)
state
recapitulated
directions
proposed.
Ultimately,
this
serve
a
resource
selection
material
methodologies
order
increase
usefulness
collagen-hydrogel-based
studies
experiments.
Advanced Materials,
Год журнала:
2015,
Номер
27(25), С. 3717 - 3736
Опубликована: Май 19, 2015
Adaptable
hydrogels
have
recently
emerged
as
a
promising
platform
for
three‐dimensional
(3D)
cell
encapsulation
and
culture.
In
conventional,
covalently
crosslinked
hydrogels,
degradation
is
typically
required
to
allow
complex
cellular
functions
occur,
leading
bulk
material
degradation.
contrast,
adaptable
are
formed
by
reversible
crosslinks.
Through
breaking
re‐formation
of
the
linkages,
can
be
locally
modified
permit
while
maintaining
their
long‐term
integrity.
addition,
these
materials
biomimetic
viscoelastic
properties
that
make
them
well
suited
several
biotechnology
medical
applications.
this
review,
an
overview
adaptable‐hydrogel
design
considerations
linkage
selections
presented,
with
focus
on
various
cell‐compatible
crosslinking
mechanisms
exploited
form
tissue
engineering.
Journal of Glaucoma,
Год журнала:
2014,
Номер
23, С. S20 - S23
Опубликована: Янв. 1, 2014
The
extracellular
matrix
(ECM)
is
an
intricate
network
composed
of
array
multidomain
macromolecules
organized
in
a
cell/tissue-specific
manner.
Components
the
ECM
link
together
to
form
structurally
stable
composite,
contributing
mechanical
properties
tissues.
also
reservoir
growth
factors
and
bioactive
molecules.
It
highly
dynamic
entity
that
vital
importance,
determining
controlling
most
fundamental
behaviors
characteristics
cells
such
as
proliferation,
adhesion,
migration,
polarity,
differentiation,
apoptosis.
Tissue Engineering Part B Reviews,
Год журнала:
2014,
Номер
20(6), С. 683 - 696
Опубликована: Июнь 13, 2014
Type
I
collagen
hydrogels
have
been
used
successfully
as
three-dimensional
substrates
for
cell
culture
and
shown
promise
scaffolds
engineered
tissues
tumors.
A
critical
step
in
the
development
of
viable
tissue
mimics
is
quantitative
characterization
hydrogel
properties
their
correlation
with
fabrication
parameters,
which
enables
to
be
tuned
match
specific
or
fulfill
engineering
requirements.
significant
body
work
has
devoted
hydrogels;
however,
due
breadth
materials
techniques
characterization,
published
data
are
often
disjoint
hence
utility
community
reduced.
This
review
aims
determine
parameter
space
covered
by
existing
identify
key
gaps
literature
so
that
future
use
research
can
most
efficiently
conducted.
divided
into
three
sections:
(1)
relevant
parameters
introduced
several
popular
methods
controlling
regulating
them
described,
(2)
presented
discussed
along
techniques,
(3)
state
recapitulated
directions
proposed.
Ultimately,
this
serve
a
resource
selection
material
methodologies
order
increase
usefulness
collagen-hydrogel-based
studies
experiments.
