International Journal of Translational Medicine,
Год журнала:
2022,
Номер
2(3), С. 419 - 447
Опубликована: Авг. 19, 2022
Despite
significant
advances
in
the
understanding
of
cancer
biology,
is
still
a
leading
cause
death
worldwide.
Expression
tumor
microenvironment
component,
osteopontin,
tissues,
plasma,
and
serum,
has
been
shown
to
be
associated
with
poor
prognosis
survival
rate
various
human
cancers.
Recent
studies
suggest
that
osteopontin
drives
development
aggressiveness
using
strategies.
In
this
review,
we
first
provide
an
overview
how
promotes
progression,
such
as
growth,
invasion,
angiogenesis,
immune
modulation,
well
metastasis
chemoresistance.
Next,
address
functional
activities
are
modulated
by
interaction
integrins
CD44
receptors,
but
also
post-translational
modification,
proteolytic
processing
several
proteases,
phosphorylation,
glycosylation.
Then,
review
activates
tumor-associated
macrophages
(TAMs)
cancer-associated
fibroblasts
(CAFs),
functions
immunosuppressor
regulating
surveillance
checkpoint
microenvironment.
Finally,
discuss
potential
applications
biomarker
therapeutic
target.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2016,
Номер
8(8), С. a005926 - a005926
Опубликована: Авг. 1, 2016
Alexandra
C.
Newton1,
Martin
D.
Bootman2
and
John
Scott3
1Department
of
Pharmacology,
University
California
at
San
Diego,
La
Jolla,
92093
2Department
Life,
Health
Chemical
Sciences,
The
Open
University,
Walton
Hall,
Milton
Keynes
MK7
6AA,
United
Kingdom
3Department
Howard
Hughes
Medical
Institute,
Washington
School
Medicine,
Seattle,
98195
Correspondence:
anewton{at}ucsd.edu
International Journal of Quantum Chemistry,
Год журнала:
2024,
Номер
124(4)
Опубликована: Фев. 13, 2024
Abstract
Combining
FDA‐approved
medications
may
increase
biological
activity
by
simultaneously
targeting
many
protein
mechanisms
while
being
less
toxic.
Gemcitabine
and
docetaxel
together
might
have
a
synergistic
impact
that
kills
cancer
cells
makes
them
more
effective
against
breast
cancer.
This
study
used
the
foundation
set
B3LYP/6–311
G
to
optimize
gemcitabine
with
structure
was
created.
Theoretical
calculations
were
made
for
ultraviolet
visible
spectrum
studied
in
gas
liquid
phase.
The
structural
stability
reactivity
of
combined
using
energy
gap
between
HOMO
LUMO,
computed
(ΔE)
4.219
eV.
electrostatic
potential
complex
determined
Mulliken
charge
population
evaluated.
Through
RDG
analysis
weak
interactions
GEDT
evaluated
topology
properties
through
ELF
LOL
analysis.
Breast
target
proteins
utilized
molecular
docking
studies.
scores
revealed
greater
binding
affinity
molecule,
confirming
superior
combinatorial
interaction
docetaxel.
Highest
ability
Caspase‐6
network
assessed
graph
theory
model.
dynamic
simulation
100
ns.
adsorption,
distribution,
metabolism,
excretion,
toxicity
characteristics
investigated,
findings
lead
compound's
safety
profile
its
use
as
potent
anticancer
medication.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2016,
Номер
8(4), С. a005900 - a005900
Опубликована: Апрель 1, 2016
Carl-Henrik
Heldin1,
Benson
Lu2,
Ron
Evans2
and
J.
Silvio
Gutkind3
1Ludwig
Institute
for
Cancer
Research,
Science
Life
Laboratory,
Uppsala
University,
SE-75124
Uppsala,
Sweden
2The
Salk
Biological
Studies,
Gene
Expression
La
Jolla,
California
92037
3National
of
Dental
Craniofacial
National
Institutes
Health,
Bethesda,
Maryland
20892-4340
Correspondence:
c-h.heldin{at}licr.uu.se
Journal of Experimental Botany,
Год журнала:
2016,
Номер
67(13), С. 3939 - 3951
Опубликована: Май 25, 2016
Diatoms
are
phytoplanktonic
organisms
that
grow
successfully
in
the
ocean
where
light
conditions
highly
variable.
Studies
of
molecular
mechanisms
acclimation
marine
diatom
Phaeodactylum
tricornutum
show
carotenoid
de-epoxidation
enzymes
and
LHCX1,
a
member
light-harvesting
protein
family,
both
contribute
to
dissipate
excess
energy
through
non-photochemical
quenching
(NPQ).
In
this
study,
we
investigate
role
other
members
LHCX
family
stress
responses.
Our
analysis
available
genomic
data
shows
presence
multiple
genes
is
conserved
feature
species
living
different
ecological
niches.
Moreover,
an
levels
four
P.
transcripts
relation
expression
photosynthetic
activity
indicates
LHCXs
differentially
regulated
under
intensities
nutrient
starvation,
mostly
modulating
NPQ
capacity.
We
conclude
abiotic
signals
converge
regulate
content
cells,
providing
way
fine-tune
harvesting
photoprotection.
our
indicate
expansion
gene
reflects
functional
diversification
its
which
could
benefit
cells
responding
variable
environments.
Molecules,
Год журнала:
2020,
Номер
25(21), С. 5144 - 5144
Опубликована: Ноя. 5, 2020
Cancer
is
one
of
the
highest
prevalent
diseases
in
humans.
The
chances
surviving
cancer
and
its
prognosis
are
very
dependent
on
affected
tissue,
body
location,
stage
at
which
disease
diagnosed.
Researchers
pharmaceutical
companies
worldwide
pursuing
many
attempts
to
look
for
compounds
treat
this
malignancy.
Most
current
strategies
fight
implicate
use
acting
DNA
damage
checkpoints,
non-receptor
tyrosine
kinases
activities,
regulators
hedgehog
signaling
pathways,
metabolic
adaptations
placed
cancer.
In
last
decade,
finding
a
lipid
peroxidation
increase
linked
15-lipoxygenases
isoform
1
(15-LOX-1)
activity
stimulation
has
been
found
specific
successful
treatments
against
This
discovery
contrasts
with
production
other
oxidation
signatures
generated
by
lipoxygenases
such
as
5-LOX
12-LOX,
cyclooxygenase
(COX-2)
have
suggested
biomarkers
inhibitors
present
anti-tumoral
antiproliferative
activities.
These
findings
support
previously
proposed
role
hydroperoxides
their
metabolites
cell
mediators.
Depletion
or
promotion
generally
related
source
associated
tissue
originates.
review
highlights
potential
therapeutical
chemical
derivatives
stimulate
block
cellular
routes
generate
disease.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(21), С. 11868 - 11868
Опубликована: Ноя. 1, 2021
How
can
single
cells
without
nervous
systems
perform
complex
behaviours
such
as
habituation,
associative
learning
and
decision
making,
which
are
considered
the
hallmark
of
animals
with
a
brain?
Are
there
molecular
that
underlie
cognitive
properties
equivalent
to
those
This
review
follows
development
idea
brains
from
Darwin’s
“root
brain
hypothesis”,
through
bacterial
chemotaxis,
recent
discovery
neuron-like
r-protein
networks
in
ribosome.
By
combining
structural
biology
view
Bayesian
approach,
this
explores
evolutionary
labyrinth
information
processing
across
scales.
Ribosomal
protein
open
window
into
what
were
probably
earliest
signalling
emerge
before
radiation
three
kingdoms.
While
ribosomal
characterised
by
long-lasting
interactions
between
their
nodes,
cell
essentially
based
on
transient
interactions.
As
corollary,
while
signals
propagated
persistent
may
be
ephemeral,
whose
constrain
diffusing
cytoplasm
durable
time,
post-translational
modifications
proteins
or
second
messenger
synthesis.
The
duration
nature
signals,
turn,
implies
different
mechanisms
for
integration
multiple
making.
Evolution
then
reinvented
metazoans.
simple
display
architectural
functional
analogies
comparison
could
suggest
scale
invariance
processing.
At
level,
significant
complexification
eukaryotic
is
associated
burst
acquisition
new
conserved
aromatic
amino
acids.
Knowing
residues
play
critical
role
allosteric
receptors
channels,
observation
suggests
general
π
charged
acids
signal
We
think
these
findings
provide
basis
designing
future
computers
organic
processors.
Scientific Reports,
Год журнала:
2021,
Номер
11(1)
Опубликована: Янв. 8, 2021
Abstract
Inflammation
plays
central
roles
in
the
immune
response.
Inflammatory
response
normally
requires
higher
energy
and
therefore
is
associated
with
glucose
metabolism.
Our
recent
study
demonstrates
that
lncRNA
HOTAIR
key
NF-kB
activation,
cytokine
expression,
inflammation.
Here,
we
investigated
if
any
role
regulation
of
metabolism
cells
during
results
demonstrate
LPS-induced
inflammation
induces
expression
transporter
isoform
1
(Glut1)
which
controls
uptake
macrophages.
Glut1
regulated
via
activation.
Importantly,
siRNA-mediated
knockdown
suppressed
suggesting
macrophage.
turn
increases
to
LPS.
We
also
found
regulates
macrophages
its
decreases
increased
uptake.
other
upstream
regulators
such
as
PTEN
HIF1α,
multimodal
functions
Overall,
our
demonstrated
by
activating
hence
metabolic
programming
potentially
meet
needs
Journal of Biological Chemistry,
Год журнала:
2024,
Номер
300(3), С. 105677 - 105677
Опубликована: Янв. 23, 2024
The
emerging
roles
of
O-GlcNAcylation,
a
distinctive
post-translational
modification,
are
increasingly
recognized
for
their
involvement
in
the
intricate
processes
protein
trafficking
and
secretion.
This
modification
exerts
its
influence
on
both
conventional
unconventional
secretory
pathways.
Under
healthy
stress
conditions,
such
as
during
diseases,
it
orchestrates
transport
proteins
within
cells,
ensuring
timely
delivery
to
intended
destinations.
O-GlcNAcylation
occurs
key
factors,
like
coat
complexes
(COPI
COPII),
clathrin,
SNAREs
(soluble
N-ethylmaleimide-sensitive
factor
attachment
receptors),
GRASP55
(Golgi
reassembly
stacking
55
kDa)
that
control
vesicle
budding
fusion
anterograde
retrograde
understanding
offers
valuable
insights
into
critical
functions
cellular
physiology
progression
including
neurodegeneration,
cancer,
metabolic
disorders.
In
this
review,
we
summarize
discuss
latest
findings
elucidating
O-GlcNAc
significance
various
human