Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease DOI Creative Commons
Rachelle Balez, Nicole Steiner, Martin Engel

и другие.

Scientific Reports, Год журнала: 2016, Номер 6(1)

Опубликована: Авг. 12, 2016

Abstract Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex pathogenesis. The plant polyphenol apigenin has been shown have anti-inflammatory and neuroprotective properties in number cell animal models; however comprehensive assessment not performed human model AD. Here we used induced pluripotent stem (iPSC) familial sporadic AD, addition healthy controls, assess activity apigenin. iPSC-derived AD neurons demonstrated hyper-excitable calcium signalling phenotype, elevated levels nitrite, increased cytotoxicity apoptosis, reduced neurite length susceptibility inflammatory stress challenge from activated murine microglia, comparison control neurons. We identified that potent with ability protect neurites viability by promoting global down-regulation cytokine nitric oxide (NO) release cells. In addition, show able via multiple means reducing frequency spontaneous Ca 2+ signals significantly caspase-3/7 mediated apoptosis. These data demonstrate broad action against pathogenesis model.

Язык: Английский

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies DOI
Piyoosh Sharma,

Pavan Srivastava,

Ankit Seth

и другие.

Progress in Neurobiology, Год журнала: 2018, Номер 174, С. 53 - 89

Опубликована: Дек. 30, 2018

Язык: Английский

Процитировано

286

Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease DOI

Boaz Styr,

Inna Slutsky

Nature Neuroscience, Год журнала: 2018, Номер 21(4), С. 463 - 473

Опубликована: Фев. 5, 2018

Язык: Английский

Процитировано

282

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration DOI Creative Commons
Anna Picca, Riccardo Calvani, Hélio José Coelho‐Júnior

и другие.

Antioxidants, Год журнала: 2020, Номер 9(8), С. 647 - 647

Опубликована: Июль 22, 2020

Oxidative stress develops as a response to injury and reflects breach in the cell’s antioxidant capacity. Therefore, fine-tuning of reactive oxygen species (ROS) generation is crucial for preserving homeostasis. Mitochondria are major source an immediate target ROS. Under different stimuli, including oxidative impaired quality control, mitochondrial constituents (e.g., DNA, mtDNA) displaced toward intra- or extracellular compartments. However, mechanisms responsible mtDNA unloading remain largely unclear. While shuttling freely within cell, can be delivered into compartment via either extrusion entire nucleoids release vesicles. Once discarded, may act damage-associated molecular pattern (DAMP) trigger innate immune inflammatory by binding danger-signal receptors. Neuroinflammation associated with large array neurological disorders which DAMPs could represent common thread supporting disease progression. The exploration non-canonical pathways involved control neurodegeneration unveil novel targets development therapeutic agents. Here, we discuss these processes setting two neurodegenerative diseases (Alzheimer’s Parkinson’s disease) Down syndrome, most frequent progeroid syndrome.

Язык: Английский

Процитировано

273

Monoaminergic neuropathology in Alzheimer’s disease DOI
Goran Šimić, Mirjana Babić Leko, Selina Wray

и другие.

Progress in Neurobiology, Год журнала: 2016, Номер 151, С. 101 - 138

Опубликована: Апрель 12, 2016

Язык: Английский

Процитировано

265

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease DOI Creative Commons
Rachelle Balez, Nicole Steiner, Martin Engel

и другие.

Scientific Reports, Год журнала: 2016, Номер 6(1)

Опубликована: Авг. 12, 2016

Abstract Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex pathogenesis. The plant polyphenol apigenin has been shown have anti-inflammatory and neuroprotective properties in number cell animal models; however comprehensive assessment not performed human model AD. Here we used induced pluripotent stem (iPSC) familial sporadic AD, addition healthy controls, assess activity apigenin. iPSC-derived AD neurons demonstrated hyper-excitable calcium signalling phenotype, elevated levels nitrite, increased cytotoxicity apoptosis, reduced neurite length susceptibility inflammatory stress challenge from activated murine microglia, comparison control neurons. We identified that potent with ability protect neurites viability by promoting global down-regulation cytokine nitric oxide (NO) release cells. In addition, show able via multiple means reducing frequency spontaneous Ca 2+ signals significantly caspase-3/7 mediated apoptosis. These data demonstrate broad action against pathogenesis model.

Язык: Английский

Процитировано

251