Molecular and Cellular Biology,
Год журнала:
2019,
Номер
39(11)
Опубликована: Март 29, 2019
Understanding
adipogenesis,
the
process
of
adipocyte
development,
may
provide
new
ways
to
treat
obesity
and
related
metabolic
diseases.
Adipogenesis
is
controlled
by
coordinated
actions
lineage-determining
transcription
factors
epigenomic
regulators.
Peroxisome
proliferator-activated
receptor
gamma
(PPARγ)
C/EBPα
are
master
"adipogenic"
factors.
In
recent
years,
a
growing
number
studies
have
reported
identification
novel
transcriptional
regulators
adipogenesis.
However,
many
these
not
been
validated
in
development
vivo
their
working
mechanisms
often
far
from
clear.
this
minireview,
we
discuss
advances
regulation
with
focus
on
shared
both
white
adipogenesis
brown
Studies
highlight
importance
investigating
differentiation
rather
than
drawing
conclusions
based
knockdown
experiments
cell
culture.
Advances
understanding
revealed
critical
roles
histone
methylation/demethylation,
acetylation/deacetylation,
chromatin
remodeling,
DNA
methylation,
microRNAs
differentiation.
We
also
future
research
directions
that
help
identify
regulating
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2016,
Номер
8(9), С. a019505 - a019505
Опубликована: Май 18, 2016
Stephen
B.
Baylin1
and
Peter
A.
Jones2
1Cancer
Biology
Program,
Johns
Hopkins
University,
School
of
Medicine,
Baltimore,
Maryland
21287
2Van
Andel
Research
Institute,
Grand
Rapids,
Michigan
49503
Correspondence:
sbaylin{at}jhmi.edu
Cold Spring Harbor Perspectives in Medicine,
Год журнала:
2016,
Номер
6(10), С. a026831 - a026831
Опубликована: Сен. 6, 2016
Yixuan
Li
and
Edward
Seto
George
Washington
University
Cancer
Center,
Department
of
Biochemistry
Molecular
Medicine,
University,
Washington,
DC
20037
Correspondence:
seto{at}gwu.edu
Signal Transduction and Targeted Therapy,
Год журнала:
2019,
Номер
4(1)
Опубликована: Дек. 17, 2019
Epigenetic
alternations
concern
heritable
yet
reversible
changes
in
histone
or
DNA
modifications
that
regulate
gene
activity
beyond
the
underlying
sequence.
dysregulation
is
often
linked
to
human
disease,
notably
cancer.
With
development
of
various
drugs
targeting
epigenetic
regulators,
epigenetic-targeted
therapy
has
been
applied
treatment
hematological
malignancies
and
exhibited
viable
therapeutic
potential
for
solid
tumors
preclinical
clinical
trials.
In
this
review,
we
summarize
aberrant
functions
enzymes
methylation,
acetylation
methylation
during
tumor
progression
highlight
inhibitors
targeted
at
enzymes.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2016,
Номер
8(4), С. a019521 - a019521
Опубликована: Апрель 1, 2016
Histone
posttranslational
modifications
represent
a
versatile
set
of
epigenetic
marks
involved
not
only
in
dynamic
cellular
processes,
such
as
transcription
and
DNA
repair,
but
also
the
stable
maintenance
repressive
chromatin.
In
this
article,
we
review
many
key
newly
identified
histone
known
to
be
deregulated
cancer
how
impacts
function.
The
latter
part
article
addresses
challenges
current
status
drug
development
process
it
applies
therapeutics.
Cardiovascular Research,
Год журнала:
2020,
Номер
117(6), С. 1450 - 1488
Опубликована: Окт. 26, 2020
Abstract
Myocardial
fibrosis,
the
expansion
of
cardiac
interstitium
through
deposition
extracellular
matrix
proteins,
is
a
common
pathophysiologic
companion
many
different
myocardial
conditions.
Fibrosis
may
reflect
activation
reparative
or
maladaptive
processes.
Activated
fibroblasts
and
myofibroblasts
are
central
cellular
effectors
in
serving
as
main
source
proteins.
Immune
cells,
vascular
cells
cardiomyocytes
also
acquire
fibrogenic
phenotype
under
conditions
stress,
activating
fibroblast
populations.
Fibrogenic
growth
factors
(such
transforming
factor-β
platelet-derived
factors),
cytokines
[including
tumour
necrosis
factor-α,
interleukin
(IL)-1,
IL-6,
IL-10,
IL-4],
neurohumoral
pathways
trigger
signalling
cascades
binding
to
surface
receptors,
downstream
cascades.
In
addition,
matricellular
macromolecules
deposited
remodelling
myocardium
regulate
assembly,
while
modulating
signal
transduction
protease
factor
activity.
Cardiac
can
sense
mechanical
stress
mechanosensitive
ion
channels
integrins,
intracellular
that
contribute
fibrosis
response
pressure
overload.
Although
subpopulations
fibroblast-like
exert
important
protective
actions
both
interstitial/perivascular
ultimately
fibrotic
changes
perturb
systolic
diastolic
function,
play
an
role
pathogenesis
arrhythmias.
This
review
article
discusses
molecular
mechanisms
involved
various
diseases,
including
infarction,
heart
failure
with
reduced
preserved
ejection
fraction,
genetic
cardiomyopathies,
diabetic
disease.
Development
fibrosis-targeting
therapies
for
patients
diseases
will
require
not
only
understanding
functional
pluralism
dissection
basis
remodelling,
but
appreciation
heterogeneity
fibrosis-associated
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2014,
Номер
6(7), С. a018762 - a018762
Опубликована: Июль 1, 2014
Ronen
Marmorstein1
and
Ming-Ming
Zhou2
1Program
in
Gene
Expression
Regulation,
Wistar
Institute,
Department
of
Chemistry,
University
Pennsylvania,
Philadelphia,
19104
2Department
Structural
Chemical
Biology,
Icahn
School
Medicine
at
Mount
Sinai,
New
York,
York
10065
Correspondence:
marmor{at}wistar.org
