The molecular hallmarks of epigenetic control

Nature Reviews Genetics, Год журнала: 2016, Номер 17(8), С. 487 - 500

Опубликована: Июнь 27, 2016

Язык: Английский

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Epigenetic plasticity and the hallmarks of cancer

Science, Год журнала: 2017, Номер 357(6348)

Опубликована: Июль 20, 2017

Cancer epigenetics in the driver's seat Recent cancer genome projects unexpectedly highlighted role of epigenetic alterations development. About half human cancers were found to harbor mutations chromatin proteins. In a Review, Flavahan et al. propose that and aberrations have potential confer on cells full range oncogenic properties represented classic “hallmarks” depiction cancer. They suggest genetic, environmental, metabolic factors can make aberrantly permissive or restrictive. Permissive creates state “epigenetic plasticity,” which activate oncogene expression cell fate changes drive Science , this issue p. eaal2380

Язык: Английский

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Epigenetic Determinants of Cancer

Cold Spring Harbor Perspectives in Biology, Год журнала: 2016, Номер 8(9), С. a019505 - a019505

Опубликована: Май 18, 2016

Stephen B. Baylin1 and Peter A. Jones2 1Cancer Biology Program, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287 2Van Andel Research Institute, Grand Rapids, Michigan 49503 Correspondence: sbaylin{at}jhmi.edu

Язык: Английский

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HiChIP: efficient and sensitive analysis of protein-directed genome architecture

Nature Methods, Год журнала: 2016, Номер 13(11), С. 919 - 922

Опубликована: Сен. 19, 2016

Язык: Английский

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Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells

Science, Год журнала: 2018, Номер 362(6413)

Опубликована: Окт. 26, 2018

The spatial organization of chromatin is pivotal for regulating genome functions. We report an imaging method tracing with kilobase- and nanometer-scale resolution, unveiling conformation across topologically associating domains (TADs) in thousands individual cells. Our data revealed TAD-like structures globular sharp domain boundaries single varied from cell to cell, occurring nonzero probabilities at all genomic positions but preferentially CCCTC-binding factor (CTCF)- cohesin-binding sites. Notably, cohesin depletion, which abolished TADs the population-average level, did not diminish cells eliminated preferential boundary positions. Moreover, we observed widespread, cooperative, multiway interactions, remained after depletion. These results provide critical insight into mechanisms underlying hub formation.

Язык: Английский

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Genomic Imprinting in Mammals

Cold Spring Harbor Perspectives in Biology, Год журнала: 2014, Номер 6(2), С. a018382 - a018382

Опубликована: Фев. 1, 2014

Denise P. Barlow1 and Marisa S. Bartolomei2 1CeMM Research Center for Molecular Medicine of the Austrian Academy Sciences, CeMM, 1090 Vienna, Austria 2Department Cell Developmental Biology, University Pennsylvania Perelman School Medicine, Philadelphia, 19104-6148 Correspondence: dbarlow{at}cemm.oeaw.ac.at bartolom{at}mail.med.upenn.edu

Язык: Английский

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Systematic mapping of functional enhancer–promoter connections with CRISPR interference

Science, Год журнала: 2016, Номер 354(6313), С. 769 - 773

Опубликована: Сен. 30, 2016

Gene expression in mammals is regulated by noncoding elements that can affect physiology and disease, yet the functions target genes of most remain unknown. We present a high-throughput approach uses clustered regularly interspaced short palindromic repeats (CRISPR) interference (CRISPRi) to discover regulatory identify their genes. assess >1 megabase sequence vicinity two essential transcription factors, MYC GATA1, nine distal enhancers control gene cellular proliferation. Quantitative features chromatin state chromosome conformation distinguish seven regulate from other do not, suggesting strategy for predicting enhancer-promoter connectivity. This CRISPRi-based be applied dissect transcriptional networks interpret contributions genetic variation human disease.

Язык: Английский

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The role of 3D genome organization in development and cell differentiation

Nature Reviews Molecular Cell Biology, Год журнала: 2019, Номер 20(9), С. 535 - 550

Опубликована: Июнь 13, 2019

Язык: Английский

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The Self-Organizing Genome: Principles of Genome Architecture and Function

Cell, Год журнала: 2020, Номер 183(1), С. 28 - 45

Опубликована: Сен. 24, 2020

Язык: Английский

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Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression

Nature Reviews Molecular Cell Biology, Год журнала: 2016, Номер 17(12), С. 756 - 770

Опубликована: Окт. 26, 2016

Язык: Английский

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