The role of histone modifications: from neurodevelopment to neurodiseases

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июль 6, 2022

Abstract Epigenetic regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and microRNA expression, play critical roles in cell differentiation organ development through spatial temporal gene regulation. Neurogenesis is a sophisticated complex process by which neural stem cells differentiate into specialized brain types at specific times regions of the brain. A growing body evidence suggests that epigenetic such as modifications, allow fine-tuning coordination spatiotemporal expressions during neurogenesis. Aberrant modifications contribute to neurodegenerative neuropsychiatric diseases. Herein, recent progress understanding regulating embryonic adult neurogenesis comprehensively reviewed. The implicated diseases are also covered, future directions this area provided.

Язык: Английский

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Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Май 22, 2023

Abstract Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin remodeling, RNA and noncoding RNAs modulate many biological processes that are crucial to development cancers. Dysregulation epigenome drives aberrant transcriptional programs. A growing body evidence suggests mechanisms modification dysregulated in human cancers might be excellent targets for tumor treatment. Epigenetics has also been shown influence immunogenicity immune cells involved antitumor responses. Thus, application therapy cancer immunotherapy their combinations may important implications Here, we present an up-to-date thorough description how modifications cell responses microenvironment (TME) epigenetics internally modify TME. Additionally, highlight therapeutic potential targeting regulators immunotherapy. Harnessing complex interplay between immunology develop therapeutics combine thereof is challenging but could yield significant benefits. The purpose this review assist understanding impact TME, so better immunotherapies can developed.

Язык: Английский

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Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders

Journal of Biosciences, Год журнала: 2020, Номер 45(1)

Опубликована: Окт. 20, 2020

Язык: Английский

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Mechanisms driving the immunoregulatory function of cancer cells

Nature reviews. Cancer, Год журнала: 2023, Номер 23(4), С. 193 - 215

Опубликована: Янв. 30, 2023

Язык: Английский

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Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

Drug Resistance Updates, Год журнала: 2020, Номер 53, С. 100720 - 100720

Опубликована: Авг. 20, 2020

Язык: Английский

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