The Still Underestimated Problem of Fungal Diseases Worldwide

Frontiers in Microbiology, Год журнала: 2019, Номер 10

Опубликована: Фев. 11, 2019

In the past few years, fungal diseases cause estimated over 1.6 million deaths annually and 1 billion people suffer from severe diseases. Public health surveillance of is generally not compulsory, suggesting that most estimates are conservative. Fungal disease can also damage plants crops, causing major losses in agricultural activities food production. Animal pathogenic fungi threatening bats, amphibians reptiles with extinction. It highest threat for animal-host plant-host species, representing (approximately 65%) pathogen-driven host loss. this complex scenario, it now clear global warming accompanying climate changes have resulted increased incidence many On basis all these factors, concerns on occurrence a pandemic origin near future been raised. context, to stop forgetting underestimating mandatory.

Язык: Английский

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Invasive Aspergillosis by Aspergillus flavus: Epidemiology, Diagnosis, Antifungal Resistance, and Management

Journal of Fungi, Год журнала: 2019, Номер 5(3), С. 55 - 55

Опубликована: Июль 1, 2019

Aspergillus flavus is the second most common etiological agent of invasive aspergillosis (IA) after A. fumigatus. However, literature describes IA in relation to fumigatus or together with other species. Certain differences exist caused by and studies on infections are increasing. Hence, we performed a comprehensive updated review due flavus. cause broad spectrum human diseases predominantly Asia, Middle East, Africa possibly its ability survive better hot arid climatic conditions compared spp. Worldwide, ~10% cases bronchopulmonary Outbreaks have usually been associated construction activities as pulmonary immunocompromised patients cutaneous, subcutaneous, mucosal forms immunocompetent individuals. Multilocus microsatellite typing well standardized differentiate isolates into different clades. intrinsically resistant polyenes. In contrast fumigatus, triazole resistance infrequently occurs mutations cyp51C gene. Overexpression efflux pumps non-wildtype strains lacking cyp51 gene can also lead high voriconazole minimum inhibitory concentrations. Voriconazole remains drug choice for treatment, amphotericin B should be avoided. Primary therapy echinocandins not first but combination monotherapy may used when azoles contraindicated.

Язык: Английский

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Antifungal Activity of Biosynthesized Silver Nanoparticles (AgNPs) against Aspergilli Causing Aspergillosis: Ultrastructure Study

Journal of Functional Biomaterials, Год журнала: 2022, Номер 13(4), С. 242 - 242

Опубликована: Ноя. 15, 2022

Currently, nanoparticles and nanomaterials are widely used for biomedical applications. In the present study, silver (AgNPs) were successfully biosynthesized using a cell-free extract (CFE) of Bacillus thuringiensis MAE 6 through green ecofriendly method. The size AgNPs was 32.7 nm, their crystalline nature confirmed by XRD, according to characterization results. A surface plasmon resonance spectrum obtained at 420 nm. Nanoparticles further characterized DLS FTIR analyses, which provided information on size, stability, functional groups. revealed less cytotoxicity against normal Vero cell line [IC50 = 155 μg/mL]. Moreover, exhibited promising antifungal activity four most common Aspergillus, including Aspergillus niger, A. terreus, flavus, fumigatus concentrations 500 μg/mL where inhibition zones 16, 20, 26, 19 mm, respectively. addition, MICs 125, 62.5, 15.62, 62.5 μg/mL, Furthermore, ultrastructural study effect AgNPs, wall's integrity homogeneity lost; membrane had separated from wall intruded into cytoplasm. conclusion, CFE B. can be as agent species causing Aspergillosis.

Язык: Английский

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Triazole Resistance in Aspergillus Species: An Emerging Problem

Drugs, Год журнала: 2017, Номер 77(6), С. 599 - 613

Опубликована: Фев. 24, 2017

Язык: Английский

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Chemodiversity in the genus Aspergillus

Applied Microbiology and Biotechnology, Год журнала: 2015, Номер 99(19), С. 7859 - 7877

Опубликована: Авг. 4, 2015

Язык: Английский

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The fungal cell wall as a target for the development of new antifungal therapies

Biotechnology Advances, Год журнала: 2019, Номер 37(6), С. 107352 - 107352

Опубликована: Фев. 21, 2019

Язык: Английский

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Extrolites of Aspergillus fumigatus and Other Pathogenic Species in Aspergillus Section Fumigati

Frontiers in Microbiology, Год журнала: 2016, Номер 6

Опубликована: Янв. 7, 2016

Aspergillus fumigatus is an important opportunistic human pathogen known for its production of a large array extrolites. Up to 63 species have been described in section Fumigati, some which also reliably reported be pathogenic, including A. felis, fischeri, fumigatiaffinis, fumisynnematus, hiratsukae, laciniosus, lentulus, novofumigatus, parafelis, pseudofelis, pseudoviridinutans, spinosus, thermomutatus, and udagawae. These share the hydrophobins, melanins, siderophores ability grow well at 37°C, but they only small molecule extrolites, that could factors pathogenicity. According literature gliotoxin other exometabolites can contributing pathogenicity, these are apparently not produced by all pathogenic species. It our hypothesis unable produce metabolites proxy-exometabolites may serve same function. We tabulate from Fumigati comparing profile those suggest producing many different kinds potential pathogens. The exometabolite data highly specific used identification closely related

Язык: Английский

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Melanin and pyomelanin in Aspergillus fumigatus: from its genetics to host interaction

International Microbiology, Год журнала: 2019, Номер 23(1), С. 55 - 63

Опубликована: Апрель 24, 2019

Язык: Английский

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Emergence and evolution of virulence in human pathogenic fungi

Trends in Microbiology, Год журнала: 2022, Номер 30(7), С. 693 - 704

Опубликована: Янв. 17, 2022

Язык: Английский

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Pathogenicity and virulence of Aspergillus fumigatus

Virulence, Год журнала: 2023, Номер 14(1)

Опубликована: Фев. 8, 2023

Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major cause of morbidity and mortality globally. Compromised lung defences arising from immunosuppression, chronic respiratory conditions or more recently, concomitant viral bacterial pulmonary recognised risks factors for development aspergillosis. In this review, we will summarise our current knowledge mechanistic basis aspergillosis with focus on emerging at-risk populations.

Язык: Английский

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