Associative Learning in Invertebrates

Cold Spring Harbor Perspectives in Biology, Год журнала: 2015, Номер 7(5), С. a021709 - a021709

Опубликована: Апрель 15, 2015

Robert D. Hawkins1,2 and John H. Byrne3 1Department of Neuroscience, Columbia University, New York, York 10032 2New State Psychiatric Institute, 3Department Neurobiology Anatomy, The University Texas Medical School at Houston, 77030 Correspondence: rdh1{at}columbia.edu

Язык: Английский

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Nonassociative learning implementation by a single memristor-based multi-terminal synaptic device

Nanoscale, Год журнала: 2016, Номер 8(45), С. 18897 - 18904

Опубликована: Янв. 1, 2016

Animals' survival is dependent on their abilities to adapt the changing environment by adjusting behaviours, which related ubiquitous learning behaviour, nonassociative learning. Thus mimicking indispensable behaviour in organisms based electronic devices vital better achieve artificial neural networks and neuromorphic computing. Here a three terminal device consisting of an oxide-based memristor NMOS transistor proposed. The with gradual conductance tuning inherently functions as synapse between sensor neurons motor presents adjustable synaptic plasticity, while attached utilized mimic modulatory effect neuromodulator released inter neurons. Such memristor-based multi-terminal allows practical implementation significant single device. In this study, experience-induced modification both habituation sensitization, was successfully achieved. dependence behavioural response strength interval presented stimuli also discussed. offers feasible experimental advantages for further study systems devices.

Язык: Английский

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RNA from TrainedAplysiaCan Induce an Epigenetic Engram for Long-Term Sensitization in UntrainedAplysia

eNeuro, Год журнала: 2018, Номер 5(3), С. ENEURO.0038 - 18.2018

Опубликована: Май 1, 2018

The precise nature of the engram, physical substrate memory, remains uncertain. Here, it is reported that RNA extracted from central nervous system Aplysia given long-term sensitization (LTS) training induced when injected into untrained animals; furthermore, RNA-induced sensitization, like training-induced required DNA methylation. In cellular experiments, treatment with trained animals was found to increase excitability in sensory neurons, but not motor dissociated naïve animals. Thus, behavioral, and a subset cellular, modifications characteristic form nonassociative memory (LTM) can be transferred by RNA. These results indicate sufficient generate an engram for LTS are consistent hypothesis epigenetic changes underlie storage .

Язык: Английский

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Nociceptive Biology of Molluscs and Arthropods: Evolutionary Clues About Functions and Mechanisms Potentially Related to Pain

Frontiers in Physiology, Год журнала: 2018, Номер 9

Опубликована: Авг. 3, 2018

Important insights into the selection pressures and core molecular modules contributing to evolution of pain-related processes have come from studies nociceptive systems in several molluscan arthropod species. These phyla, chordates that include humans, last shared a common ancestor approximately 550 million years ago. Since then, animals these phyla continued be subject traumatic injury, often predators, which has led similar adaptive behaviors (e.g., withdrawal, escape, recuperative behavior) physiological responses injury each group. Comparisons across taxa provide clues about contributions convergent conservation ancient mechanisms general functions. Primary nociceptors been investigated extensively few species, with long-lasting sensitization gastropod, Aplysia, insect, Drosophila, being especially fruitful. In as model for aversive memory hyperalgesia. Neuromodulator-induced, activity-dependent, axotomy-induced plasticity defined synapses, cell bodies, axons Aplysia primary nociceptors. Studies Drosophila larvae revealed numerous contributors interacting cells. Interestingly, examined thus far are largely different, but both sets overlap those mammalian pathways. contrast results moth (Manduca) disclosed central hyperactivity no obvious peripheral responses. Squid (Doryteuthis) show injury-induced manifested behavioral hypersensitivity tactile visual stimuli, spontaneous activity nociceptor terminals. Temporary blockade during subsequently increased mortality when injured squid were exposed fish providing first demonstration any animal adaptiveness sensitization. Immediate noxious stimulation also behaviorally physiologically snail (Helix), octopus (Adopus), crayfish (Astacus), hermit crab (Pagurus), shore (Hemigrapsus). Molluscs arthropods suppress responses, whether opioid play antinociceptive roles is uncertain.

Язык: Английский

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Lymnaea stagnalis as model for translational neuroscience research: From pond to bench

Neuroscience & Biobehavioral Reviews, Год журнала: 2019, Номер 108, С. 602 - 616

Опубликована: Ноя. 28, 2019

Язык: Английский

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What can we teach Lymnaea and what can Lymnaea teach us?

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Год журнала: 2021, Номер 96(4), С. 1590 - 1602

Опубликована: Апрель 6, 2021

This review describes the advantages of adopting a molluscan complementary model, freshwater snail Lymnaea stagnalis, to study neural basis learning and memory in appetitive avoidance classical conditioning; as well operant conditioning its aerial respiratory escape behaviour. We firstly explored 'what we can teach Lymnaea' by discussing variety sensitive, solid, easily reproducible simple behavioural tests that have been used uncover abilities this model system. Answering question will allow us open new frontiers neuroscience research enhance our understanding how nervous system mediates memory. In fact, from translational perspective, help understand transformation pathways output sensory coding more complex systems like mammalian brain. Moving on second question: us?', it is now known shares important associative characteristics with vertebrates, including stimulus generalization, generalization extinction discriminative learning, opening possibility use snails animal models for research.

Язык: Английский

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Handling and Training of Wild Animals: Evidence and Ethics-Based Approaches and Best Practices in the Modern Zoo

Animals, Год журнала: 2023, Номер 13(14), С. 2247 - 2247

Опубликована: Июль 9, 2023

There is an ethical responsibility to provide all animals living in human care with optimal and positive well-being. As zoos aquariums frequently interact their caregivers as part of daily routines, it both relevant essential consider the impact these interactions on animal Allowing have choice control multiple areas lives, such by providing opportunities for them voluntarily participate own through, example, reinforcement training, component good well-being programs. This review aims describe evidence-based approaches, ethics, best practices handling training many taxa held worldwide, drawing from work related fields laboratories, farms, rescue, sanctuaries. The importance ongoing assessments discussed, a particular focus need continued refinement processes procedures pertaining specifically. Review, enquiry, assessment, evaluation, will aim dynamically support animals.

Язык: Английский

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Neuromorphic device based on silicon nanosheets

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Сен. 5, 2022

Abstract Silicon is vital for its high abundance, vast production, and perfect compatibility with the well-established CMOS processing industry. Recently, artificially stacked layered 2D structures have gained tremendous attention via fine-tuning properties electronic devices. This article presents neuromorphic devices based on silicon nanosheets that are chemically exfoliated surface-modified, enabling self-assembly into hierarchical stacking structures. The device functionality can be switched between a unipolar memristor feasibly reset-able synaptic device. memory function of charge storage in partially oxidized SiNS stacks followed by discharge activated electric field at Au-Si Schottky interface, as verified both experimental theoretical means. work further inspired elegant computation models digit recognition noise filtration. Ultimately, it brings - most established semiconductor back to forefront next-generation computations.

Язык: Английский

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Memory Retrieval in Mice and Men

Cold Spring Harbor Perspectives in Biology, Год журнала: 2015, Номер unknown, С. a021790 - a021790

Опубликована: Окт. 5, 2015

Aya Ben-Yakov1, Yadin Dudai1,2 and Mark R. Mayford3 1Department of Neurobiology, Weizmann Institute Science, Rehovot 76100, Israel 2Center for Neural New York University, York, 10003 3Department Molecular Cellular Neuroscience, The Scripps Research Institute, La Jolla, California 92037 Correspondence: yadin.dudai{at}weizmann.ac.il; mmayford{at}scripps.edu

Язык: Английский

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Memristor-Based Neural Network Circuit of Emotional Habituation With Contextual Dependency

IEEE Internet of Things Journal, Год журнала: 2023, Номер 10(19), С. 17382 - 17391

Опубликована: Май 10, 2023

Most memristor-based neural networks only consider habituation under repeated stimuli, but the emotional stimuli is ignored. In this article, a network circuit that can realize with contextual dependency proposed. The designed consists of module, emotion control context and generalization module. When different are applied, module produces feedback voltages has an impact on formation habituation. addition, influence information considered achieved. Finally, achieved through simulation results in PSPICE indicate proposed dependency. provides some references for brain-like intelligence.

Язык: Английский

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