
Biological Psychiatry, Год журнала: 2023, Номер 93(12), С. 1071 - 1080
Опубликована: Янв. 17, 2023
Язык: Английский
Biological Psychiatry, Год журнала: 2023, Номер 93(12), С. 1071 - 1080
Опубликована: Янв. 17, 2023
Язык: Английский
Nature Neuroscience, Год журнала: 2020, Номер 23(8), С. 952 - 958
Опубликована: Июнь 8, 2020
Язык: Английский
Процитировано
78Frontiers in Behavioral Neuroscience, Год журнала: 2022, Номер 16
Опубликована: Апрель 25, 2022
Long-term potentiation (LTP) and long-term depression (LTD) comprise the principal cellular mechanisms that fulfill established criteria for physiological correlates of learning memory. Traditionally LTP, increases synaptic weights, has been ascribed a prominent role in memory whereas LTD, decreases them, often relegated to category “counterpart LTP” serves prevent saturation synapses. In contradiction these assumptions, studies over last several years have provided functional evidence distinct roles LTD specific aspects hippocampus-dependent associative information encoding. Furthermore, experience-dependent “pruning” excitatory synapses, majority which are located on dendritic spines, by means provided. addition, reports exist temporal physical restriction LTP compartments LTD. Here, we discuss encoding based empirical derived from conjoint behavioral electrophysiological conducted behaving rodents. We pinpoint close interrelation between structural modifications spines occurrence report findings support acquire general scheme spatial representation, enables retention content details. argue contributes engaging interplay with rather than serving as its simple counterpart, or negator. propose similar experiences share elements neuronal representations can be modified enable pattern separation. Therewith, plays crucial disambiguation prevention generalization.
Язык: Английский
Процитировано
48Nature, Год журнала: 2023, Номер 623(7986), С. 263 - 273
Опубликована: Ноя. 8, 2023
Язык: Английский
Процитировано
41Nature Neuroscience, Год журнала: 2023, Номер 26(2), С. 339 - 349
Опубликована: Янв. 12, 2023
Язык: Английский
Процитировано
31Cell Reports, Год журнала: 2023, Номер 42(1), С. 111962 - 111962
Опубликована: Янв. 1, 2023
The lateral entorhinal cortex (LEC) provides multisensory information to the hippocampus, directly distal dendrites of CA1 pyramidal neurons. LEC neurons perform important functions for episodic memory processing, coding contextually salient elements an environment or experience. However, we know little about functional circuit interactions between and hippocampus. We combine mapping computational modeling examine how long-range glutamatergic projections modulate compartment-specific excitation-inhibition dynamics in hippocampal area CA1. demonstrate that inputs can drive local dendritic spikes neurons, aided by recruitment a disinhibitory VIP interneuron microcircuit. Our further reveal also recruit CCK interneurons may act as strong suppressors spikes. These results highlight cortically driven GABAergic microcircuit mechanism gates nonlinear computations, which support contextual features within
Язык: Английский
Процитировано
29Biology of Sex Differences, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 31, 2025
Obstructive sleep apnea (OSA) is an intermittent hypoxia disorder associated with cognitive dysfunction, including learning and memory impairments. There evidence that alterations in protease activity neuronal activation are dependent on sex, may be brain region-specific. However, the mechanisms mediating OSA-induced impairments unclear. Therefore, we used a rat model of OSA, chronic (CIH) to investigate (e.g., calpain caspase-3) spectrin, cytoskeletal protein neurotransmitter release, (early growth response 1, EGR-1) regions memory. Male female Sprague Dawley rats were exposed CIH or room air (normoxic) for 14 days. We quantified cleaved spectrin products, along EGR-1 expression hippocampal subregions (CA1, CA3), cortical [entorhinal cortex (ETC), retrosplenial (RSC), cerebellar (CC)], subcortical [raphe nucleus (RN), locus coeruleus (LC)] Within each group, Pearson correlations activity, caspase-3 performed between regions. Sex differences within normoxic examined. dysregulated male ETC, CA1 RSC. RN, decreased cleavage products ETC. calpain-cleaved RSC but increased these was RN. Correlational analysis revealed excitatory connections males inhibitory females. shifted from negative positive correlations. Overall, data indicate dysregulates impairs function region- sex-dependent manner. This indicates females exhibit sex-specific vulnerabilities mild OSA. These findings concur our previous behavioral studies demonstrated impairment CIH-exposed rats.
Язык: Английский
Процитировано
2Neuron, Год журнала: 2017, Номер 95(5), С. 1089 - 1102.e5
Опубликована: Авг. 1, 2017
Язык: Английский
Процитировано
87Cell Reports, Год журнала: 2018, Номер 25(10), С. 2704 - 2715.e4
Опубликована: Дек. 1, 2018
The supramammillary nucleus (SuM) of the hypothalamus projects to dentate gyrus (DG) and CA2 region hippocampus. Although SuM-to-hippocampus circuits have been implicated in spatial emotional memory formation, little is known about precise neural connections between SuM Here, we report that axons neurons make monosynaptic granule cells (GCs) GABAergic interneurons, but not hilar mossy cells, DG co-release glutamate γ-aminobutyric acid (GABA) at these synapses. inputs from can excite some alone fail generate spikes GCs. However, despite insufficient excitatory drive co-transmission, net effects on GCs potentiate GC firing when temporally associated with perforant path inputs. Our results indicate influences information processing by modulating outputs.
Язык: Английский
Процитировано
75Cell Reports, Год журнала: 2018, Номер 23(8), С. 2379 - 2391
Опубликована: Май 1, 2018
Social interactions are essential to our mental health, and a deficit in social is hallmark characteristic of numerous brain disorders. Various subregions within the medial temporal lobe have been implicated memory, but underlying mechanisms that tune these neural circuits remain unclear. Here, we demonstrate optical activation excitatory entorhinal cortical perforant projections dentate gyrus (EC-DG) necessary sufficient for memory retrieval. We further show inducible disruption p21-activated kinase (PAK) signaling, key pathway important cytoskeletal reorganization, EC-DG circuit leads impairments synaptic function recognition and, importantly, optogenetic terminals reverses deficits transgenic mice. These results provide compelling evidence underlies recall PAK signaling may play critical role modulating this process.
Язык: Английский
Процитировано
74Current Biology, Год журнала: 2019, Номер 29(3), С. 367 - 380.e4
Опубликована: Янв. 3, 2019
Язык: Английский
Процитировано
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