Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy

Biomedicines, Год журнала: 2021, Номер 9(9), С. 1077 - 1077

Опубликована: Авг. 24, 2021

Intracellular Ca

Язык: Английский

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Crosstalk between Ca2+ Signaling and Cancer Stemness: The Link to Cisplatin Resistance

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(18), С. 10687 - 10687

Опубликована: Сен. 14, 2022

In the fight against cancer, therapeutic strategies using cisplatin are severely limited by appearance of a resistant phenotype. While is usually efficient at beginning treatment, several patients endure resistance to this agent and face relapse. One reasons for phenotype emergence cell subpopulation known as cancer stem cells (CSCs). Due their quiescent self-renewal abilities, these have recently been recognized crucial field investigation in treatment resistance. Changes intracellular calcium (Ca2+) through Ca2+ channel activity essential many cellular processes such proliferation, migration, differentiation, survival various types. It now proved that altered signaling hallmark channels linked CSC functions therapy Moreover, was shown interfere with homeostasis; thus, it considered likely cisplatin-induced aberrant CSCs biology and, therefore, failure. The molecular signature defining varies between tumors, number mechanisms activated response range pressures dictates global degree However, if we can understand linking behaviors, alternative novel could be considered. review, examine how interferes homeostasis tumor cells. We also summarize induces markers cancer. Finally, highlight role stemness focus on they involved increase populations via specific pathways.

Язык: Английский

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Human cancer cells generate spontaneous calcium transients and intercellular waves that modulate tumor growth

Biomaterials, Год журнала: 2022, Номер 290, С. 121823 - 121823

Опубликована: Окт. 5, 2022

Electrically excitable cells such as neurons transmit long-distance calcium or electrical signals to regulate their physiological functions. While the molecular underpinnings and down-stream effects of these intercellular communications in have been well appreciated, little is known about whether how non-excitable cancer spontaneously initiate signals. Here we report that human colon prostate spread waves, vitro ex vivo. Xenograft model studies suggest promote growth rate tumors mice. Pharmacological elucidated inositol-trisphosphate-receptor (IP3R)-regulated release from endoplasmic reticulum (ER), which activated by Gq-PLC-IP3R pathway, a major cause for initiation spontaneous transients. Further, spatial-temporal characteristics dynamics can be tuned culture substrates different mechanical stiffnesses. Our results provide evidence enables functional communication offer potential modulate signaling new therapies.

Язык: Английский

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Azelnidipine nanoparticles break calcium homeostasis and induce severe ER stress combined with medroxyprogesterone acetate for endometrial cancer therapy

Nano Today, Год журнала: 2022, Номер 47, С. 101682 - 101682

Опубликована: Ноя. 9, 2022

Язык: Английский

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Intermittent hypoxia promotes largemouth bassheart adaptation through increasing angiogenesis, reprogramming calcium signaling, and upregulating mitochondrial turnover

Aquaculture, Год журнала: 2023, Номер 579, С. 740195 - 740195

Опубликована: Окт. 5, 2023

Язык: Английский

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