Emerging mechanistic understanding of cilia function in cellular signalling
Nature Reviews Molecular Cell Biology,
Год журнала:
2024,
Номер
25(7), С. 555 - 573
Опубликована: Фев. 16, 2024
Язык: Английский
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Nature Reviews Endocrinology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Язык: Английский
TERT prevents obesity-induced metabolic disorders by promoting adipose stem cell expansion and differentiation
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Abstract
Obesity
is
linked
to
limited
adipose
tissue
(AT)
remodeling
capacity,
leading
hypertrophic
adipocytes,
senescence,
and
inflammation.
We
used
a
mouse
model
expressing
mTert
(p21
+/Tert
)
from
the
Cdkn1a
locus
investigate
role
of
mTERT
in
obesity-induced
metabolic
disorders.
Conditional
expression
reduces
disorders
associated
with
obesity.
In
AT,
this
accompanied
by
decrease
number
senescent
p21-positive
cells,
very
short
telomeres,
oxidative
DNA
damage.
Single
nucleus
RNA-seq
data
reveal
TERT
attenuates
senescence
induced
HFD
particular
stem
progenitor
cells
(ASPC).
show
that
ASPC
expansion
differentiation
are
promoted
p21
obese
mice,
thereby
reducing
further
report
remodels
landscape
macrophages
AT
mice.
Strikingly,
inactivation
catalytic
activity
+/TertCi
mice
suppresses
promotion
adipocyte
formation,
but
neither
affects
attenuation
nor
macrophage
remodeling.
These
results
highlight
mTERT’s
canonical
non-canonical
functions
obesity-associated
thus
appears
as
potential
therapeutic
option
for
Язык: Английский
Human brown fat and metabolic disease: a heated debate
Journal of Clinical Investigation,
Год журнала:
2023,
Номер
133(23)
Опубликована: Ноя. 30, 2023
Язык: Английский
PDGFRβ + cell HIF2α is dispensable for white adipose tissue metabolic remodeling and hepatic lipid accumulation in obese mice
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Март 20, 2024
Abstract
Background
Obesity
is
associated
with
extensive
white
adipose
tissue
(WAT)
expansion
and
remodeling.
Healthy
WAT
contributes
to
the
maintenance
of
energy
balance
in
liver,
thereby
ameliorating
obesity-related
hepatic
steatosis.
Tissue-resident
mesenchymal
stromal
cell
populations,
including
PDGFRβ
+
perivascular
cells,
are
increasingly
recognized
pivotal
as
determinants
manner
which
expands.
However,
full
array
regulatory
factors
controlling
functions
remains
be
fully
elucidated.
Hypoxia-inducible
(HIFs)
critical
regulators
populations
such
adipocyte
precursor
cells
(APCs).
It
revealed
that
HIF1α
activation
within
results
suppression
de
novo
adipogenesis
promotion
a
pro-fibrogenic
cellular
program
obese
animals.
role
HIF2α
undetermined
vivo.
Methods
New
genetic
models
were
employed
(encoded
by
Hif1a
gene)
Epas1
selectively
inactivated
an
inducible
using
tamoxifen
(TAM).
With
these
models,
both
vitro
vivo
functional
analysis
lacking
HIF
proteins
performed.
Additionally,
comprehensive
metabolic
phenotyping
diet-induced
mouse
performed
investigate
roles
remodeling,
liver
systemic
metabolism.
Results
Unlike
inactivation,
new
findings
this
study
suggest
ablation
does
not
cause
apparent
effects
on
induced
obesogenic
diet.
The
adipogenic
ability
APCs
significantly
altered
ablation.
Moreover,
no
difference
key
parameters
healthy
remodeling
improvements
insulin
sensitivity,
reduction
inflammation,
well
changes
fat
accumulation
or
glucose
metabolism,
detected
-deficient
mice.
Conclusion
support
that,
contrast
HIF1α,
appears
dispensable
for
resulting
homeostasis
obesity,
underscoring
isoform-specific
HIFα
regulation
biology.
Язык: Английский
Mesenchymal Stromal Cell Secretome Restores Immune Profile Towards Tissue Regeneration in a Model of Liver Fibrosis with Acute Lung Injury
Опубликована: Янв. 1, 2024
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DOI
Язык: Английский
Slit3 Fragments Orchestrate Neurovascular Expansion and Thermogenesis in Brown Adipose Tissue
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 26, 2024
Brown
adipose
tissue
(BAT)
represents
an
evolutionary
innovation
enabling
placental
mammals
to
regulate
body
temperature
through
adaptive
thermogenesis.
adipocytes
are
surrounded
by
a
dense
network
of
blood
vessels
and
sympathetic
nerves
that
support
their
development
thermogenic
function.
Cold
exposure
stimulates
BAT
thermogenesis
the
coordinated
induction
brown
adipogenesis,
angiogenesis,
innervation.
However,
how
these
distinct
processes
remains
unclear.
Here,
we
identify
Slit
guidance
ligand
3
(Slit3)
as
new
niche
factor
mediates
crosstalk
among
adipocyte
progenitors,
endothelial
cells,
nerves.
We
show
progenitors
secrete
Slit3
which
regulates
both
angiogenesis
innervation
in
is
essential
for
vivo.
Proteolytic
cleavage
generates
secreted
Slit3-N
Slit3-C
fragments,
activate
receptors
stimulate
innervation,
respectively.
Moreover,
introduce
bone
morphogenetic
protein-1
(Bmp1)
first
protease
identified
vertebrates.
In
summary,
this
study
underscores
role
Slit3-mediated
neurovascular
expansion
cold-induced
adaptation.
The
co-regulation
fragments
provides
bifurcated
yet
harmonized
approach
ensure
synchronized
response
environmental
challenges.
This
presents
evidence
revealing
previously
unrecognized
dimension
cellular
interaction
within
tissue.
Язык: Английский