The role of moonlighting proteins in neurogenesis
Current Opinion in Neurobiology,
Год журнала:
2025,
Номер
93, С. 103047 - 103047
Опубликована: Май 15, 2025
The
complexity
of
the
mammalian
brain
must
arise
from
a
comparably
small
number
genes.
Proteins
with
moonlighting
functions,
i.e.
entirely
different
functions
in
compartments
or
cell
types,
contribute
to
multiply
functional
diversity.
Here
we
review
examples
such
proteins
during
neurogenesis
and
neuronal
maturation.
These
range
cytoskeletal
acting
as
transcriptional
regulators
synaptic
exon
junction
binding
regulating
cytoskeleton
immediate
early
gene
transcription
factors
lipid
metabolism
endoplasmic
reticulum.
We
further
discuss
how
heterogeneity
organelles
shaping
cell-type
diversity
brain.
Язык: Английский
Early spinal cord development: from neural tube formation to neurogenesis
Nature reviews. Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Язык: Английский
Mitochondrial and photosynthetic therapy: A crucial strategy for remodeling cellular metabolic function
Bioengineering & Translational Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 19, 2025
Abstract
Extranuclear
organelle
transplantation,
an
emerging
field
in
cell
biology
and
bioengineering,
presents
innovative
therapeutic
possibilities
by
transferring
organelles
such
as
mitochondria
between
cells
or
across
species.
In
living
organisms,
chloroplasts
are
closely
related
to
converting
substances
energy
within
cells.
Transplantation
therapy
of
seeks
rebuild
metabolic
function
diseased
damaged
has
broad
application
potential
treating
diseases.
The
therapies
provide
a
distinctive
technology
for
cellular
restoration
targeting
generation
at
the
level,
which
will
offer
new
resources
animal
At
present,
mitochondrial
transplantation
been
applied
novel
approach
rescue
patients
clinical
settings,
chloroplast‐based
endows
utilize
light
(photosynthetic
cells).
this
review,
we
discuss
exciting
development
prospects
photosynthetic
biomedicine.
extranuclear
would
exert
profound
impacts
on
biological
therapy.
Язык: Английский
Exploring Framework Nucleic Acids: A Perspective on Their Cellular Applications
JACS Au,
Год журнала:
2024,
Номер
4(11), С. 4110 - 4128
Опубликована: Окт. 22, 2024
Cells
are
fundamental
units
of
life.
The
coordination
cellular
functions
and
behaviors
relies
on
a
cascade
molecular
networks.
Technologies
that
enable
exploration
manipulation
specific
events
in
living
cells
with
high
spatiotemporal
precision
would
be
critical
for
pathological
study,
disease
diagnosis,
treatment.
Framework
nucleic
acids
(FNAs)
represent
novel
class
acid
materials
characterized
by
their
monodisperse
rigid
nanostructure.
Leveraging
exceptional
programmability,
convenient
modification
property,
predictable
atomic-level
architecture,
FNAs
have
attracted
significant
attention
diverse
applications
such
as
cell
recognition,
imaging,
manipulation,
therapeutic
interventions.
In
this
perspective,
we
will
discuss
the
utilization
systems
while
critically
assessing
opportunities
challenges
presented
burgeoning
field.
Язык: Английский