Role of TRAP1 Protein in the Development and Progression of Glioblastoma DOI Creative Commons
Ilgiz Gareev, A. S. Yasinskaya, S. A. Roumiantsev

и другие.

Creative Surgery and Oncology, Год журнала: 2024, Номер 14(4), С. 369 - 381

Опубликована: Дек. 28, 2024

Glioblastoma is recognized as the most aggressive type of primary brain tumor. Despite recent advances in understanding molecular mechanisms involved biology glioblastoma, patient survival rates remain disappointing, primarily due to lack effective treatment options. Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member heat shock 90 (Hsp90) family, refers predominantly localized mitochondria that regulates both cellular metabolic reprogramming and mitochondrial apoptosis. This highly expressed several types tumors, including colorectal cancer, breast prostate lung often associated with drug resistance. However, TRAP1 also downregulated certain cancers such ovarian bladder renal where its lower expression correlates poorer prognoses chemoresistance. The role lies enhancing or suppressing oxidative phosphorylation, impact regulation on tumor development progression being matter ongoing debate. These observations prompt further investigation into responsible for dual an oncogene suppressor specific particularly glioblastoma. present study reviews glioblastoma discusses potential targeting novel therapeutic approach against tumors.

Язык: Английский

An MRI Radiogenomic Signature to Characterize the Transcriptional Heterogeneity Associated with Prognosis and Biological Functions in Glioblastoma DOI Creative Commons
Xiaoqing Zhang,

Xiaoyu Zhang,

Jie Zhu

и другие.

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(3)

Опубликована: Март 19, 2025

Background: The study sought to establish a radiogenomic signature evaluate the transcriptional heterogeneity that reflects prognosis and tumour-related biological functions of patients with glioblastoma. Methods: Transcriptional subclones were identified via fully unsupervised deconvolution RNA sequencing. A genomic prognostic risk score was developed from subclone proportions in development dataset (n = 532) independently verified testing 225). Multimodal magnetic resonance imaging (MRI) analysis involved feature extraction three distinct anatomical regions across four sequences. Key features selected construct predictive 99), subsequent survival conducted image 233). Results: total 8 identified, which metabolic pathway spinocerebellar ataxia independent factors for overall survival. effectively differentiated patient subgroups divergent outcomes both (p < 0.001) datasets 0.0003). Nineteen radiomic signature, these being linked hallmark cancer pathways malignant behaviours cells. predicted (hazard ratios (HR) 1.67, p 0.011). Conclusions: established characterize underlying

Язык: Английский

Процитировано

0
Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptations DOI Creative Commons

Yixin Fu,

Yong Yi, Yongxiang Shao

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 4, 2025

Glioblastoma, one of the most aggressive and heterogeneous malignant tumors, presents significant challenges for clinical management due to its cellular metabolic complexity. This review integrates recent advancements in single-cell RNA sequencing (scRNA-seq) spatial transcriptomics elucidate glioblastoma’s heterogeneity reprogramming. Diverse subpopulations, including proliferative cells, stem-like mesenchymal-like immune-related contribute tumor progression, treatment resistance, microenvironmental interactions. Spatial has further revealed distinct distributions these highlighting differences activities between core periphery. Key adaptations, such as enhanced glycolysis, fatty acid oxidation, glutamine metabolism, play critical roles supporting growth, immune evasion, therapeutic resistance. Targeting pathways, especially combination with immunotherapy, represents a promising avenue glioblastoma treatment. emphasizes importance integrating multi-omics technologies decode landscape explore novel strategies. By addressing current challenges, redundancy spatiotemporal dynamics, this work provides insights into advancing precision medicine glioblastoma.

Язык: Английский

Процитировано

0
Incorporating Targeted Therapy Into Neuro-Oncology Practice DOI
Marjolein Geurts, Juan Bautista Blaquier, Maarten M.J. Wijnenga

и другие.

American Society of Clinical Oncology Educational Book, Год журнала: 2025, Номер 45(3)

Опубликована: Апрель 11, 2025

The integration of targeted therapies into neuro-oncology is revolutionizing the management primary CNS malignancies. Advances in sequencing technologies and incorporation molecular alterations tumor classification have led to more precise prognosis enabled identification actionable oncogenic drivers. However, challenges such as drug delivery, microenvironment heterogeneity, limitations preclinical models complicate selection effective therapies. This review presents a comprehensive framework for optimizing neuro-oncology. We discuss strategies enhance development improve clinical trial success, including window-of-opportunity trials advanced imaging techniques. Additionally, we highlight recent advances treatment isocitrate dehydrogenase–mutant gliomas, focusing on INDIGO study its role regulatory approval vorasidenib. also examines use MAPK inhibitors, from BRAF inhibitors PAN-RAF both pediatric adult patients, well novel investigational agents. Finally, explore emerging rarer drivers, FGFR NTRK alterations, emphasizing need CNS-specific strategies.

Язык: Английский

Процитировано

0
The application progress of PAMAM dendrimer in cancer imaging and treatment DOI Creative Commons

Cong-Ying Zhang,

Kai Gu,

Mengyi Chi

и другие.

Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 38

Опубликована: Апрель 28, 2025

Polyamidoamine dendrimer (PAMAM) are effective carriers that transport diagnostic imaging reagents and drugs to the tumor site. Their excellent bio-compatibility bio-degradability reduce damage healthy tissues, resulting in improved treatment efficacy. Dendrimer molecules particularly useful targeted drug delivery within malignant cells. This article reviews recent progress of PAMAM treating breast cancer, lung hepatocellular colorectal gastric prostate glioblastoma. review aims provide new feasible ideas for cancer diagnosis while also serving as a significant reference point personalized therapy based on materials.

Язык: Английский

Процитировано

0
New ALKBH2 and ALKBH5 inhibitors for treating glioblastoma DOI Creative Commons
Mirko Rivara, Gabriella Nicolini, Alessio Malacrida

и другие.

Results in Chemistry, Год журнала: 2024, Номер 9, С. 101645 - 101645

Опубликована: Июль 1, 2024

Glioblastoma is an aggressive brain tumor with high mortality and a median survival of about 15 months. Starting from our previous published compound, MV1035 that inhibited migration invasiveness glioblastoma U87 cells, also exhibited synergic effect in combination the alkylating agent Temozolomide, we identified new active molecules, aim to understand key motifs responsible for activity against DNA repair protein ALKBH2 RNA demethylase ALKBH5. We modified original structure MV1035, synthesizing molecules have been tested through MTT assay, cell-free assay ALKBH5 assay. found compound 6 able reduce both obtained important information these inhibitors. However, considering complexity, heterogeneity plasticity GBM GSC will need be validated vivo.

Язык: Английский

Процитировано

2
Amino Acid Deprivation in Glioblastoma: The Role in Survival and the Tumour Microenvironment—A Narrative Review DOI Creative Commons

Kevin Du,

Leila Grocott,

Giulio Anichini

и другие.

Biomedicines, Год журнала: 2024, Номер 12(11), С. 2481 - 2481

Опубликована: Окт. 29, 2024

Glioblastoma is the most common and aggressive primary brain tumour, characterised by its invasive nature complex metabolic profile. Emerging research highlights role of amino acids (AAs) in glioblastoma metabolism, influencing tumour growth surrounding microenvironment.

Язык: Английский

Процитировано

1
Role of TRAP1 Protein in the Development and Progression of Glioblastoma DOI Creative Commons
Ilgiz Gareev, A. S. Yasinskaya, S. A. Roumiantsev

и другие.

Creative Surgery and Oncology, Год журнала: 2024, Номер 14(4), С. 369 - 381

Опубликована: Дек. 28, 2024

Glioblastoma is recognized as the most aggressive type of primary brain tumor. Despite recent advances in understanding molecular mechanisms involved biology glioblastoma, patient survival rates remain disappointing, primarily due to lack effective treatment options. Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member heat shock 90 (Hsp90) family, refers predominantly localized mitochondria that regulates both cellular metabolic reprogramming and mitochondrial apoptosis. This highly expressed several types tumors, including colorectal cancer, breast prostate lung often associated with drug resistance. However, TRAP1 also downregulated certain cancers such ovarian bladder renal where its lower expression correlates poorer prognoses chemoresistance. The role lies enhancing or suppressing oxidative phosphorylation, impact regulation on tumor development progression being matter ongoing debate. These observations prompt further investigation into responsible for dual an oncogene suppressor specific particularly glioblastoma. present study reviews glioblastoma discusses potential targeting novel therapeutic approach against tumors.

Язык: Английский

Процитировано

0