Oral Exposure to Clostridium difficile Toxin A Aggravates Food Allergy by Intestinal Barrier Destruction, Mast Cell Activation, and Th2-Biased Immune Responses DOI

Xiaoqian Xu,

Cuiying He,

Jin Yuan

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Food allergy is a complex disease, with multiple environmental factors involved. Considering the regulatory effect of Clostridium difficile toxin A (Tcd A) on biological processes allergic reactions, role oral exposure to Tcd food was investigated. The intestinal permeability and β-hexosaminidase were promoted by using in vitro Caco-2 HT-29 cells coculture monolayer bone marrow-derived mast cell (MCs) degranulation model. When sensitized mice challenged OVA 4 μg A, specific IgE MCPT-1 levels increased. results flow cytometry ELISA demonstrated that Th1 Treg reduced higher IL-5 induced. jejunum staining showed villus injury MC accumulation aggravated. All findings could aggravate allergy, orally exposed risk aggravating warrant increasing attention.

Язык: Английский

Combined processing technologies: Promising approaches for reducing Allergenicity of food allergens DOI
Lidong Pang, Runze Li, Chen Chen

и другие.

Food Chemistry, Год журнала: 2024, Номер 463, С. 141559 - 141559

Опубликована: Окт. 5, 2024

Язык: Английский

Процитировано

5
Oral Exposure to Clostridium difficile Toxin A Aggravates Food Allergy by Intestinal Barrier Destruction, Mast Cell Activation, and Th2-Biased Immune Responses DOI

Xiaoqian Xu,

Cuiying He,

Jin Yuan

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Food allergy is a complex disease, with multiple environmental factors involved. Considering the regulatory effect of Clostridium difficile toxin A (Tcd A) on biological processes allergic reactions, role oral exposure to Tcd food was investigated. The intestinal permeability and β-hexosaminidase were promoted by using in vitro Caco-2 HT-29 cells coculture monolayer bone marrow-derived mast cell (MCs) degranulation model. When sensitized mice challenged OVA 4 μg A, specific IgE MCPT-1 levels increased. results flow cytometry ELISA demonstrated that Th1 Treg reduced higher IL-5 induced. jejunum staining showed villus injury MC accumulation aggravated. All findings could aggravate allergy, orally exposed risk aggravating warrant increasing attention.

Язык: Английский

Процитировано

0