Circulation Research,
Год журнала:
2020,
Номер
126(4), С. 533 - 551
Опубликована: Фев. 13, 2020
During
aging,
deterioration
in
cardiac
structure
and
function
leads
to
increased
susceptibility
heart
failure.
The
need
for
interventions
combat
this
age-related
decline
is
becoming
increasingly
urgent
as
the
elderly
population
continues
grow.
Our
understanding
of
aging
general,
limited.
However,
recent
studies
its
prevention
through
like
exercise
have
revealed
novel
pathological
cardioprotective
pathways.
In
review,
we
summarize
findings
concerning
molecular
mechanisms
failure
highlight
a
valuable
experimental
platform
discovery
much-needed
therapeutic
targets
chronic
disease.
Frontiers in Endocrinology,
Год журнала:
2020,
Номер
11
Опубликована: Май 21, 2020
Cardiovascular
diseases
have
become
the
leading
cause
of
human
death.
Aging
is
an
independent
risk
factor
for
cardiovascular
diseases.
Cardiac
aging
associated
with
maladaptation
cellular
metabolism,
dysfunction
(or
senescence)
cardiomyocytes,
a
decrease
in
angiogenesis,
and
increase
tissue
scarring
(fibrosis).
These
events
eventually
lead
to
cardiac
remodeling
failure.
Senescent
cardiomyocytes
show
hallmarks
DNA
damage,
endoplasmic
reticulum
stress,
mitochondria
dysfunction,
contractile
hypertrophic
growth,
senescence-associated
secreting
phenotype
(SASP).
Metabolism
within
essential
not
only
fuel
pump
function
heart
but
also
maintain
functional
homeostasis
participate
senescence
cardiomyocytes.
The
cardiomyocyte
regulated
by
non-myocytes
(endothelial
cells,
fibroblasts,
immune
cells)
local
microenvironment.
On
other
hand,
senescent
alter
their
phenotypes
subsequently
affect
microenvironment
contribute
pathological
remodeling.
In
this
review,
we
first
summarized
Then,
discussed
metabolic
switch
provided
discussion
communications
between
dysfunctional
We
addressed
functions
regulators
modulating
myocardial
Finally,
pointed
out
some
interesting
important
questions
that
are
needed
be
further
studies.
Aging and Disease,
Год журнала:
2022,
Номер
13(1), С. 103 - 103
Опубликована: Янв. 1, 2022
Aging
is
a
prominent
risk
factor
for
cardiovascular
diseases,
which
the
leading
cause
of
death
around
world.
Recently,
cellular
senescence
has
received
potential
attention
as
promising
target
in
preventing
including
acute
myocardial
infarction,
atherosclerosis,
cardiac
aging,
pressure
overload-induced
hypertrophy,
heart
regeneration,
hypertension,
and
abdominal
aortic
aneurysm.
Here,
we
discuss
mechanisms
underlying
describe
involvement
senescent
cells
(including
cardiomyocytes,
endothelial
cells,
vascular
smooth
muscle
fibroblasts/myofibroblasts
T
cells)
age-related
diseases.
Then,
highlight
targets
(SIRT1
mTOR)
that
regulating
disorders.
Furthermore,
review
evidence
can
exert
both
beneficial
detrimental
implications
diseases
on
context-dependent
manner.
Finally,
summarize
emerging
pro-senescent
or
anti-senescent
interventions
their
therapeutic
The Lancet Healthy Longevity,
Год журнала:
2022,
Номер
3(1), С. e67 - e77
Опубликована: Янв. 1, 2022
Cellular
senescence
is
a
major
contributor
to
age-related
diseases
in
humans;
however,
it
also
has
beneficial
role
physiological
and
pathological
processes,
including
wound
healing,
host
immunity,
tumour
suppression.
Reducing
the
burden
of
cell
animal
models
cardiometabolic
disorders,
inflammatory
conditions,
neurodegenerative
diseases,
cancer
using
pharmaceutical
approaches
that
selectively
target
senescent
cells
(ie,
senolytics)
or
suppress
senescence-associated
secretory
phenotype
senomorphics)
holds
great
promise
for
management
chronic
age-associated
conditions.
Although
studies
have
provided
evidence
senolytics
senomorphics
are
effective
at
decreasing
number
humans,
short-term
long-term
side-effects
these
therapies
largely
unknown.
In
this
Review,
we
systematically
discuss
been
investigated
clinical
trials
used
off-label,
presenting
their
various
adverse
effects.
Despite
potential
senotherapeutics
transform
anti-ageing
medicine,
cautionary
approach
regarding
unwanted
dose-dependent
should
be
adopted.
Cells,
Год журнала:
2023,
Номер
12(9), С. 1296 - 1296
Опубликована: Май 2, 2023
Senescent
cell
accumulation
has
been
observed
in
age-associated
diseases
including
cardiovascular
diseases.
cells
lack
proliferative
capacity
and
secrete
senescence-associated
secretory
phenotype
(SASP)
factors
that
may
cause
or
worsen
many
Therapies
targeting
senescent
cells,
especially
senolytic
drugs
selectively
induce
removal,
have
shown
to
delay,
prevent,
alleviate,
treat
multiple
preclinical
models.
Some
clinical
trials
already
completed
are
underway
for
a
number
of
geriatric
syndromes.
Understanding
how
cellular
senescence
affects
the
various
types
system,
such
as
endothelial
vascular
smooth
muscle
fibroblasts,
immune
progenitor
cardiomyocytes,
is
important
facilitate
translation
senotherapeutics
into
interventions.
This
review
highlights:
(1)
characteristics
their
involvement
diseases,
focusing
on
aforementioned
types,
(2)
evidence
about
other
senotherapeutics,
(3)
future
path
potential
Nature Aging,
Год журнала:
2024,
Номер
4(9), С. 1231 - 1248
Опубликована: Июль 1, 2024
Accumulating
senescent
cells
within
tissues
contribute
to
the
progression
of
aging
and
age-related
diseases.
Botanical
extracts,
rich
in
phytoconstituents,
present
a
useful
resource
for
discovering
therapies
that
could
target
senescence
thus
improve
healthspan.
Here,
we
show
daily
oral
administration
standardized
extract
Salvia
haenkei
(Haenkenium
(HK))
extended
lifespan
healthspan
naturally
aged
mice.
HK
treatment
inhibited
age-induced
inflammation,
fibrosis
markers
across
several
tissues,
as
well
increased
muscle
strength
fur
thickness
compared
with
age-matched
controls.
We
also
found
reduced
acutely
induced
by
chemotherapeutic
agent
doxorubicin,
using
p16
Redox Biology,
Год журнала:
2024,
Номер
70, С. 103032 - 103032
Опубликована: Янв. 21, 2024
Thioredoxin
(Trx)
is
a
compact
redox-regulatory
protein
that
modulates
cellular
redox
state
by
reducing
oxidized
proteins.
Trx
exhibits
dual
functionality
as
an
antioxidant
and
cofactor
for
diverse
enzymes
transcription
factors,
thereby
exerting
influence
over
their
activity
function.
has
emerged
pivotal
biomarker
various
diseases,
particularly
those
associated
with
oxidative
stress,
inflammation,
aging.
Recent
clinical
investigations
have
underscored
the
significance
of
in
disease
diagnosis,
treatment,
mechanistic
elucidation.
Despite
its
paramount
importance,
intricate
interplay
between
senescence-a
condition
characterized
irreversible
growth
arrest
induced
multiple
aging
stimuli-remains
inadequately
understood.
In
this
review,
our
objective
to
present
comprehensive
up-to-date
overview
structure
function
Trx,
involvement
signaling
pathways
senescence,
association
age-related
well
potential
therapeutic
target.
Our
review
aims
elucidate
novel
extensive
role
senescence
while
highlighting
implications
diseases.
Cells,
Год журнала:
2024,
Номер
13(4), С. 353 - 353
Опубликована: Фев. 17, 2024
Cardiovascular
diseases
(CVDs),
a
group
of
disorders
affecting
the
heart
or
blood
vessels,
are
primary
cause
death
worldwide,
with
an
immense
impact
on
patient
quality
life
and
disability.
According
to
World
Health
Organization,
CVD
takes
estimated
17.9
million
lives
each
year,
where
more
than
four
out
five
deaths
due
attacks
strokes.
In
decades
come,
increased
prevalence
age-related
CVD,
such
as
atherosclerosis,
coronary
artery
stenosis,
myocardial
infarction
(MI),
valvular
disease,
failure
(HF)
will
contribute
even
greater
health
economic
burden
global
average
expectancy
increases
consequently
world’s
population
continues
age.
Considering
this,
it
is
important
focus
our
research
efforts
understanding
fundamental
mechanisms
underlying
CVD.
this
review,
we
cellular
senescence
mitochondrial
dysfunction,
which
have
long
been
established
We
also
assess
recent
advances
in
targeting
dysfunction
including
energy
starvation
oxidative
stress,
mitochondria
dynamics
imbalance,
cell
apoptosis,
mitophagy,
therapies
that
influence
both
therefore
perhaps
represent
strategies
most
clinical
potential,
range,
utility.
