Train and Reprogram Your Brain: Effects of Physical Exercise at Different Stages of Life on Brain Functions Saved in Epigenetic Modifications

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12043 - 12043

Опубликована: Ноя. 9, 2024

Multiple studies have demonstrated the significant effects of physical exercise on brain plasticity, enhancement memory and cognition, mood improvement. Although beneficial impact functions mental health is well established, exact mechanisms underlying this phenomenon are currently under thorough investigation. Several hypotheses emerged suggesting various possible mechanisms, including hormones, neurotrophins, neurotransmitters, more recently also other compounds such as lactate or irisin, which released circumstances act both locally or/and distant tissues, triggering systemic body reactions. Nevertheless, none these actually explain long-lasting effect exercise, can persist for years even be passed to subsequent generations. It believed that mediated through epigenetic modifications, influencing expression particular genes translation modification specific proteins. This review explores regular function plasticity associated occurrence modifications. examines how changes contribute prevention treatment neuropsychiatric neurological disorders, their influence natural aging process health.

Язык: Английский

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RNA Epigenetics in Chronic Lung Diseases

Genes, Год журнала: 2022, Номер 13(12), С. 2381 - 2381

Опубликована: Дек. 16, 2022

Chronic lung diseases are highly prevalent worldwide and cause significant mortality. Lung cancer is the end stage of many chronic diseases. RNA epigenetics can dynamically modulate gene expression decide cell fate. Recently, studies have confirmed that plays a crucial role in developing Further exploration underlying mechanisms diseases, including cancer, may lead to better understanding promote development new biomarkers therapeutic strategies. This article reviews basic information on modifications, N6 methylation adenosine (m6A), N1 (m1A), N7-methylguanosine (m7G), 5-methylcytosine (m5C), 2'O-methylation (2'-O-Me or Nm), pseudouridine (5-ribosyl uracil Ψ), inosine editing (A-to-I editing). We then show how they relate different types disease. paper hopes summarize modification disease finds way develop early diagnosis treatment

Язык: Английский

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ceRNA network construction and identification of hub genes as novel therapeutic targets for age-related cataracts using bioinformatics

PeerJ, Год журнала: 2023, Номер 11, С. e15054 - e15054

Опубликована: Март 23, 2023

Background The aim of this study is to investigate the genetic and epigenetic mechanisms involved in pathogenesis age-related cataract (ARC). Methods We obtained transcriptome datafile th ree ARC samples three healthy, age-matched used differential expression analyses identify differentially expressed genes (DEGs). lncRNA-associated competing endogenous (ceRNA) network, protein-protein network (PPI) were constructed using Cytoscape STRING. Cluster performed underlying molecular hub affecting progression. To verify immune status patients, immune-associated also conducted. Results PPI identified FOXO1 gene as with highest score, calculated by Maximal Clique Centrality (MCC) algorithm. ceRNA lncRNAs H19, XIST, TTTY14, MEG3 FOXO1, NOTCH3, CDK6, SPRY2, CA2 playing key roles regulating ARC. Additionally, showed no significant correlation an response but highly correlated cell metabolism, including cysteine, methionine, galactose. Discussion findings may provide clues toward pathogenic be significance for future therapeutic research.

Язык: Английский

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Epitranscriptomics: new players in an old game

Biochemical Society Transactions, Год журнала: 2023, Номер 51(2), С. 783 - 796

Опубликована: Апрель 4, 2023

Ageing is a conserved and unavoidable biological process characterized by progressive decline of physiological functions with time. Despite constituting the greatest risk factor for most human diseases, little known about molecular mechanisms driving ageing process. More than 170 chemical RNA modifications, also as epitranscriptome, decorate eukaryotic coding non-coding RNAs have emerged novel regulators metabolism, modulating stability, translation, splicing or processing. Studies on short-lived organisms such yeast worms connect mutations modifying enzymes lifespan changes, dysregulation epitranscriptome has been linked to age-related diseases hallmarks themselves in mammals. Moreover, transcriptome-wide analyses are starting reveal changes messenger modifications neurodegenerative expression some modifiers age. These studies put focus potential regulator lifespan, open new avenues identification targets treat diseases. In this review, we discuss connection between enzymatic machinery regulating their deposition RNAs, hypothesize role regulation other ncRNAs playing key ageing, transposable elements tRNA fragments. Finally, reanalyze available datasets mouse tissues during report wide transcriptional proteins involved deposition, removal decoding several best-known modifications.

Язык: Английский

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A signature of five 7-methylguanosine-related genes is a prognostic marker for lung squamous cell carcinoma

Journal of Thoracic Disease, Год журнала: 2023, Номер 15(11), С. 6265 - 6278

Опубликована: Ноя. 1, 2023

Background: N7-methylguanosine (m7G) is an important posttranscriptional modification affecting mRNA and tRNA functions stability. The genes regulating the m7G process have been previously found involved in carcinogenesis process. We aimed to analyze role of m7G-related as potential prognostic markers for lung squamous cell carcinoma (LSCC). Methods: Twenty-nine were selected analysis LSCC cohort Cancer Genome Atlas (TCGA). Univariate, multivariate, Kaplan-Meier analyses used evaluate predictive value risk model developed with signature overall survival (OS).. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment differentially expressed (DEGs) performed high- low-risk groups. Results: identified 17 methylation-related versus normal tissues. expression five (EIF3D, LSM1, NCBP2, NUDT10, NUDT11) was independent marker OS patients. A these predicted 2-, 3-year rates 0.623 0.626, respectively. score significantly correlated OS: patients a higher had shorter (P<0.01) it associated lower immune response (P<0.01). Conclusions: novel gene that can be great utility predict prognosis LSCC.

Язык: Английский

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