VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis

Free Radical Biology and Medicine, Год журнала: 2022, Номер 193, С. 720 - 735

Опубликована: Ноя. 1, 2022

Язык: Английский

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Ganoderic acid D prevents oxidative stress‐induced senescence by targeting 14‐3‐3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells

Aging Cell, Год журнала: 2022, Номер 21(9)

Опубликована: Авг. 5, 2022

Abstract Stem cell senescence is an important cause of aging. Delaying may present a novel way to combat aging and age‐associated diseases. This study provided mechanistic insight into the protective effect ganoderic acid D (GA‐D) against human amniotic mesenchymal stem (hAMSCs) senescence. GA‐D, Ganoderma lucidum ‐derived triterpenoid, markedly prevented hAMSCs via activating Ca 2+ calmodulin (CaM)/CaM‐dependent protein kinase II (CaMKII)/nuclear erythroid 2‐related factor 2 (Nrf2) axis, 14‐3‐3ε was identified as target GA‐D. 14‐3‐3ε‐encoding gene ( YWHAE ) knockdown in reversed activation CaM/CaMKII/Nrf2 signals attenuate GA‐D anti‐aging increase senescence‐associated β ‐galactosidase (SA‐ ‐gal), p16 p21 expression levels, including reactive oxygen species (ROS) production, thereby promoting cycle arrest decreasing differentiation potential. overexpression maintained or slightly enhanced effect. d ‐galactose‐caused mice by significantly increasing total antioxidant capacity, well superoxide dismutase glutathione peroxidase activity, reducing formation malondialdehyde, advanced glycation end products, receptor products. Consistent with mechanism senescence, delayed bone‐marrow cells this model vivo, reduced SA‐ ‐gal ROS alleviated arrest, viability regulating axis. Therefore, retards targeting activate signaling pathway. Furthermore, vivo involve regulation same signal

Язык: Английский

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Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources

Biomolecules, Год журнала: 2023, Номер 13(11), С. 1600 - 1600

Опубликована: Окт. 31, 2023

Aging is a natural and inescapable phenomenon characterized by progressive deterioration of physiological functions, leading to increased vulnerability chronic diseases death. With economic medical development, the elderly population gradually increasing, which poses great burden society, economy field. Thus, healthy aging has now become common aspiration among people over world. Accumulating evidence indicates that substances can mediate deteriorated processes are highly likely have potential prolong lifespan improve aging-associated diseases. Foods from sources full bioactive compounds, such as polysaccharides, polyphenols, carotenoids, sterols, terpenoids vitamins. These compounds their derivatives been shown be able delay and/or diseases, thereby prolonging lifespan, via regulation various processes. Here, we summarize current understanding anti-aging activities vitamins food sources, modes action in delaying improving This will certainly provide reference for further research on effects sources.

Язык: Английский

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Ion channel Piezo1 activation aggravates the endothelial dysfunction under a high glucose environment

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Май 3, 2024

Abstract Background Vasculopathy is the most common complication of diabetes. Endothelial cells located in innermost layer blood vessels are constantly affected by flow or vascular components; thus, their mechanosensitivity plays an important role mediating regulation. damage, one main causes hyperglycemic complications, has been extensively studied. However, mechanosensitive signaling endothelial damage remains unclear. Methods Vascular endothelial-specific Piezo1 knockout mice were generated to investigate effects on Streptozotocin-induced hyperglycemia and injury. In vitro activation knockdown was performed evaluate proliferation, migration, tubular function human umbilical vein high glucose. Reactive oxygen species production, mitochondrial membrane potential alternations, oxidative stress-related products used assess extent stress caused activation. Results Our study found that VE CreERT2 ;Piezo1 flox/flox with conditional cells, deficiency alleviated streptozotocin-induced reduced apoptosis abscission thoracic aortic decreased inflammatory response tissue Moreover, showed a thinner wall, tunica media increased nitric oxide synthase expression transgenic mice, indicating relief hyperglycemia. We also aggravated injury resulted severe dysfunction through Ca 2+ -induced CaMKII-Nrf2 axis cells. partially restored superoxide dismutase activity malondialdehyde content aorta. Mechanistically, CaMKII phosphorylation Nrf2 its downstream molecules HO-1 NQO1. Conclusion summary, our revealed involved glucose-induced dysfunction, which have great significance for alleviating

Язык: Английский

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Dietary Triterpenoids in Functional Food and Drug Ingredients: a review of structure-activity relationships, biosynthesis, applications, and AI-driven strategies

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104961 - 104961

Опубликована: Март 1, 2025

Язык: Английский

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Unveiling the Spatiotemporal Landscape of Ganoderma lingzhi: Insights into Ganoderic Acid Distribution and Biosynthesis

Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Methionine sulfoxide reductase A deficiency aggravated ferroptosis in LPS-induced acute kidney injury by inhibiting the AMPK/NRF2 axis and activating the CaMKII/HIF-1α pathway

Free Radical Biology and Medicine, Год журнала: 2025, Номер 234, С. 248 - 263

Опубликована: Апрель 25, 2025

Язык: Английский

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Hydrogen sulfide mitigates mitochondrial dysfunction and cellular senescence in diabetic patients: Potential therapeutic applications

Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116556 - 116556

Опубликована: Сен. 1, 2024

Язык: Английский

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Increased production and anti-senescence activity of exopolysaccharides in Ganoderma lingzhi by co-overexpression of β-1,3-glucan synthase and UDP-glucose pyrophosphorylase

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126778 - 126778

Опубликована: Сен. 6, 2023

Язык: Английский

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14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 26, 2024

Abstract Over the past decade, role of 14–3-3 protein has received increasing interest. Seven subtypes proteins exhibit high homology; however, each subtype maintains its specificity. The 14–3-3ε is involved in various physiological processes, including signal transduction, cell proliferation, apoptosis, autophagy, cycle regulation, repolarization cardiac action, development, intracellular electrolyte homeostasis, neurodevelopment, and innate immunity. It also plays a significant development progression diseases, such as cardiovascular inflammatory neurodegenerative disorders, cancer. These immense involvements diverse processes makes it promising target for drug development. Although extensive research been conducted on dimers, studies monomers are limited. This review aimed to provide an overview recent reports molecular mechanisms regulation binding partners by 14–3-3ε, focusing issues that could help advance frontiers this field.

Язык: Английский

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