Exploring the acute and chronic effects of a multi-strain probiotic supplement on cognitive function and mood in healthy older adults: A randomised controlled trial

American Journal of Clinical Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Ageing, is associated with a decline in cognitive function and vulnerability to depression. Probiotic supplements have shown beneficial effects on cognition mood clinical populations, but the potential benefit for healthy older adults experiencing age-related remains unclear. The primary aim of present work was explore effect chronic (long-term) multi-species probiotic intervention ageing adults. Secondary aims included exploring outcomes gut microbiota community, as well novel investigation into acute supplementation mood. study employed randomised, placebo-controlled, cross-over trial 30 (1 day) (8 weeks) supplement domains memory executive function, alongside measures stress, anxiety, depression, reactivity sad 16s rRNA sequencing stool samples also performed pre- post- assess microbiota. Acute faster reaction times cognitively demanding trials during task [-64.91ms, CI -115.70, -14.15]. Chronic improvement biases such hopelessness [-0.97, -1.72, -0.23], rumination [-1.58, -2.86, -0.29] aggression [-1.57, -2.63, -0.51] that contribute therefore may improve under higher demand [0.43%, -0.53%, 1.38%]. current provides evidence an probiotics which should be replicated future work. Additionally, this replicates previous findings improved following supplementation, indicating reduce risk developing depression population. This registered at https://clinicaltrials.gov/study/NCT04951687.

Язык: Английский

---

Improving intestinal inflammaging to delay aging? A new perspective

Mechanisms of Ageing and Development, Год журнала: 2023, Номер 214, С. 111841 - 111841

Опубликована: Июнь 30, 2023

Язык: Английский

---

Protective Properties of Intestinal Alkaline Phosphatase Supplementation on the Intestinal Barrier: Interactions and Effects

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 72(1), С. 27 - 45

Опубликована: Ноя. 15, 2023

The intestinal barrier is critical for maintaining homeostasis, and its dysfunction associated with various diseases. Recent findings have revealed the multifunctional role of alkaline phosphatase (IAP) in diverse biological processes, including gut health maintenance function. This review summarizes protective effects IAP on integrity, encompassing physical, chemical, microbial, immune barriers. We discuss results insights from vitro, animal model, clinical studies as well available evidence regarding impact diet activity expression. can also be used an indicator to assess intestinal-barrier-related Further research into mechanisms action long-term overall essential future use a dietary supplement or functional component medical foods.

Язык: Английский

---

Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice

Frontiers in Aging, Год журнала: 2024, Номер 5

Опубликована: Март 4, 2024

Introduction: Aging studies in humans and mice have played a key role understanding the intestinal microbiome an increased abundance of “inflammaging” Gram-negative (Gn) bacteria. The mechanisms underlying this inflammatory profile aging are unknown. We tested hypothesis that aging-related decrease colonic crypt epithelial cell anti-microbial peptide (AMP) gene expression could promote Gn dysbiosis inflammaging. Methods: As model aging, C57BL/6J fecal (colonic) microbiota (16S) isolated (RNA-seq) were assessed at 2 months (mth) (human: 18 years old; yo), 15 mth 50 25 84 yo). Informatics examined microbial compositions, differential expressions, correlations between bacteria expressions. Results: Fecal exhibited significantly relative abundances pro-inflammatory with aging. Colonic analysis showed significant age-related downregulation AMP genes repress growth expressions is correlated (dysbiosis), loss barrier expression, senescence- inflammation-related expression. Conclusion: This study supports proposed promotes inflammaging-associated markers These data may support new targets for therapies based on microbiomes.

Язык: Английский

---

Anemia and Its Connections to Inflammation in Older Adults: A Review

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(7), С. 2049 - 2049

Опубликована: Апрель 2, 2024

Anemia is a common hematological disorder that affects 12% of the community-dwelling population, 40% hospitalized patients, and 47% nursing home residents. Our understanding impact inflammation on iron metabolism erythropoiesis still lacking. In older adults, anemia can be divided into nutritional deficiency anemia, bleeding unexplained anemia. The last type might caused by reduced erythropoietin (EPO) activity, progressive EPO resistance bone marrow erythroid progenitors, chronic subclinical pro-inflammatory state. Overall, one-third patients with demonstrate deficiency, have state kidney disease, suffer from unknown etiology. Understanding anemia’s pathophysiology in people aged 65 over crucial because it contributes to frailty, falls, cognitive decline, decreased functional ability, higher mortality risk. Inflammation produces adverse effects cells system. These include (hypoferremia), production, elevated phagocytosis erythrocytes hepatic splenic macrophages. Additionally, causes enhanced eryptosis due oxidative stress circulation. Identifying mechanisms behind age-related essential for better preventing adults.

Язык: Английский

---

Astragalus polysaccharide: implication for intestinal barrier, anti-inflammation, and animal production

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Май 2, 2024

Intestine is responsible for nutrients absorption and plays a key role in defending against various dietary allergens, antigens, toxins, pathogens. Accumulating evidence reported critical of intestine maintaining animal human health. Since the use antibiotics as growth promoters feed has been restricted many countries, alternatives to have globally investigated, polysaccharides are considered environmentally friendly promising improve intestinal health, which become research hotspot due its antibiotic substitution effect. Astragalus polysaccharide (APS), biological macromolecule, extracted from astragalus exhibit complex activities involved barrier integrity maintenance, microbiota regulation, short-chain fatty acids (SCFAs) production, immune response The activity APS related chemical structure. In this review, we outlined source structure APS, highlighted recent findings on regulation physical barrier, biochemical immunological well latest progress an substitute production. We hope review could provide scientific basis new insights application nutrition, clinical medicine health by understanding particular effects anti-inflammation,

Язык: Английский

---

Gut microbiota, a hidden protagonist of traditional Chinese medicine for acute ischemic stroke

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Апрель 13, 2023

Acute ischemic stroke (AIS) is one of the leading diseases causing death and disability worldwide, treatment options remain very limited. Traditional Chinese Medicine (TCM) has been used for thousands years to treat proven have significant efficacy, but its mechanism action still unclear. As research related brain-gut-microbe axis progresses, there increasing evidence that gut microbiota plays an important role during AIS. The interaction between TCM suggested as a possible key link therapeutic effects TCM. We compiled reviewed recent studies on relationship AIS, TCM, microbiota, with expectation providing more ideas elucidate in

Язык: Английский

---

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 22, 2024

SUMMARY Intestinal stem cells (ISCs) drive the rapid regeneration of gut epithelium to maintain organismal homeostasis. Aging, however, significantly reduces intestinal regenerative capacity. While cellular senescence is a key feature aging process, little known about in vivo effects senescent on fitness. Here, we identify accumulation and, by harnessing senolytic CAR T eliminate them, uncover their detrimental impact epithelial integrity and overall homeostasis natural aging, injury colitis. Ablation with or vitro sufficient promote potential aged ISCs. This intervention improves mucosal immune function. Overall, these results highlight ability rejuvenate niche demonstrate targeted cell therapies tissue organisms.

Язык: Английский

---

Is the Myasthenia Gravis (MG) the Result of Age and Sex/Gender? A Narrative Review for Identifying Genetic and Epigenetic Biomarkers for a Differential MG Management in Old and Young Women

Опубликована: Апрель 30, 2024

Myasthenia gravis (MG) is a disease characterized by typical clinical and immunopathogenic pe-culiarities, which correlate with age sex/gender. Accordingly, MG patients show thymic al-terations auto-antibodies productions, that can be the expression of different pathogenetic mechanism related to gender. This determines, in relation at sex/gender, dif-ferent onset, prognosis, outcome. Therefore, diverse forms identified, classi-fied, their features, precisely there are early onset late-onset MG. It has been hypothesized cause appearance two ascribed mainly genetic epigenetic factors. In this narrative review, we will analyze discuss about interplay age- sex-related factors (i.e. genet-ic factors) how they contribute di-verse pathogenesis.

Язык: Английский

---

Emerging Insights into Postoperative Neurocognitive Disorders: The Role of Signaling Across the Gut-Brain Axis

Molecular Neurobiology, Год журнала: 2024, Номер 61(12), С. 10861 - 10882

Опубликована: Май 27, 2024

The pathophysiological regulatory mechanisms in postoperative neurocognitive disorders (PNCDs) are intricately complex. Currently, the pathogenesis of PNCDs has not been fully elucidated. mechanism involved may include a variety factors, such as neuroinflammation, oxidative stress, and neuroendocrine dysregulation. Research into gut microbiota-induced regulations on brain functions is increasingly becoming focal point exploration. Emerging evidence shown that intestinal bacteria play an essential role maintaining homeostasis various physiological systems regulating disease occurrence. Recent studies have confirmed association gut-brain axis with central nervous system diseases. However, effects this remain unclear. Therefore, paper intends to review bidirectional signaling PNCDs, summarize latest research progress, discuss possible affecting This aimed at providing scientific reference for predicting clinical risk PNCD patients identifying early diagnostic markers prevention targets.

Язык: Английский

---