L-Theanine Extends the Lifespan of Caenorhabditis elegans by Reducing the End Products of Advanced Glycosylation
Foods,
Год журнала:
2025,
Номер
14(2), С. 221 - 221
Опубликована: Янв. 13, 2025
L-theanine,
a
non-protein
amino
acid
naturally
occurring
in
tea
leaves,
is
recognized
for
its
antioxidant,
anti-inflammatory,
and
neuroprotective
properties.
Despite
known
benefits,
the
mechanisms
by
which
L-theanine
influences
lifespan
extension
remain
poorly
understood.
This
study
investigated
effects
of
on
Caenorhabditis
elegans
explored
underlying
mechanisms.
Our
findings
indicate
that
significantly
diminishes
accumulation
advanced
glycation
end
products
(AGEs),
are
biomarkers
closely
linked
to
aging
age-related
diseases.
Through
an
AGE-level
analysis,
we
observed
when
administered
during
early
adulthood,
notably
extended
under
both
normal
high-glucose-induced
stress
conditions.
enhanced
typical
conditions
provided
protective
against
stress.
A
further
analysis
demonstrated
extends
modulating
DAF-2/DAF-16
insulin-like
signaling
pathway
reducing
(AGEs).
In
summary,
this
identified
as
potential
anti-aging
intervention
AGE
regulating
pathways.
These
provide
new
insights
developing
strategies
lay
groundwork
research
benefits
mammals.
Future
studies
could
explore
molecular
mechanisms,
test
mammalian
models,
assess
long-term
side
effects.
Язык: Английский
Combinatorial transcriptomic and genetic dissection of insulin/IGF‐1 signaling‐regulated longevity in Caenorhabditis elegans
Aging Cell,
Год журнала:
2024,
Номер
23(7)
Опубликована: Март 26, 2024
Abstract
Classical
genetic
analysis
is
invaluable
for
understanding
the
interactions
underlying
specific
phenotypes,
but
requires
laborious
and
subjective
experiments
to
characterize
polygenic
quantitative
traits.
Contrarily,
transcriptomic
enables
simultaneous
objective
identification
of
multiple
genes
whose
expression
changes
are
associated
with
phenotypes.
Here,
we
conducted
crucial
longevity
using
datasets
daf‐2
/insulin/IGF‐1
receptor
mutant
Caenorhabditis
elegans
.
Our
unraveled
epistatic
relationships
at
level,
in
addition
verifying
genetically
established
interactions.
combinatorial
also
revealed
conferred
by
mutations.
In
particular,
demonstrated
that
extent
lifespan
caused
various
alleles
transcription
factor
daf‐16
/
FOXO
matched
their
effects
on
mutants.
We
identified
aging‐regulating
signaling
pathways
subsets
structural
functional
RNA
elements
altered
different
Lastly,
elucidated
cooperation
between
several
regulators,
based
combination
molecular
analysis.
These
data
suggest
biological
processes
coordinately
exert
networks.
Together
our
work
demonstrates
utility
dissection
identifying
important
physiological
processes,
including
aging
longevity.
Язык: Английский