Therapy-Induced Senescence: Novel Approaches for Markers Identification DOI Open Access
Francesco Pacifico, Fulvio Magni, Antonio Leonardi

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8448 - 8448

Опубликована: Авг. 2, 2024

Therapy-induced senescence (TIS) represents a major cellular response to anticancer treatments. Both malignant and non-malignant cells in the tumor microenvironment undergo TIS may be harmful for cancer patients since develop senescence-associated secretory phenotype (SASP) that can sustain growth. The SASP also modulates anti-tumor immunity, although immune populations involved final results appear context-dependent. In addition, senescent are able evade growth arrest resume proliferation, likely contributing relapse. So, research data suggest induction negatively affects therapy outcomes patients. line with this, new interventions aimed at removal of or reprogramming their SASP, called senotherapy, have become attractive therapeutic options. To date, lack reliable, cost-effective, easy-to-use biomarkers hinders application recent anti-senescence approaches clinic. Hence, identification detection non-neoplastic is high priority research. this review article, we describe current knowledge about TIS, outline critical gaps our knowledge, address advances novel discovery biomarkers.

Язык: Английский

Therapy-Induced Senescence: Novel Approaches for Markers Identification DOI Open Access
Francesco Pacifico, Fulvio Magni, Antonio Leonardi

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8448 - 8448

Опубликована: Авг. 2, 2024

Therapy-induced senescence (TIS) represents a major cellular response to anticancer treatments. Both malignant and non-malignant cells in the tumor microenvironment undergo TIS may be harmful for cancer patients since develop senescence-associated secretory phenotype (SASP) that can sustain growth. The SASP also modulates anti-tumor immunity, although immune populations involved final results appear context-dependent. In addition, senescent are able evade growth arrest resume proliferation, likely contributing relapse. So, research data suggest induction negatively affects therapy outcomes patients. line with this, new interventions aimed at removal of or reprogramming their SASP, called senotherapy, have become attractive therapeutic options. To date, lack reliable, cost-effective, easy-to-use biomarkers hinders application recent anti-senescence approaches clinic. Hence, identification detection non-neoplastic is high priority research. this review article, we describe current knowledge about TIS, outline critical gaps our knowledge, address advances novel discovery biomarkers.

Язык: Английский

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