Discovery of genomic and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end products using correlated meta‐analyses: The Long Life Family Study

Aging Cell, Год журнала: 2024, Номер 23(10)

Опубликована: Июнь 26, 2024

Abstract Patients with chronic kidney disease (CKD) have increased oxidative stress and inflammation, which may escalate the production of advanced glycation end‐products (AGEs). High soluble receptor for AGE (sRAGE) low estimated glomerular filtration rate (eGFR) levels are associated CKD aging. We evaluated whether eGFR calculated from creatinine cystatin C share pleiotropic genetic factors sRAGE. employed whole‐genome sequencing correlated meta‐analyses on combined genome‐wide association study (GWAS) p ‐values in 4182 individuals (age range: 24–110) Long Life Family Study (LLFS). also conducted transcriptome‐wide studies (TWAS) whole blood a subset 1209 individuals. identified 59 GWAS loci ( < 5 × 10 −8 ) 17 TWAS genes (Bonferroni‐ 2.73 −6 traits genes, LSP1 MIR23AHG , were sRAGE located within loci, lncRNA‐ KCNQ1OT1 CACNA1A/CCDC130 respectively. variants eQTLs glomeruli tubules, predicted carcinoma. harbored kidney, carcinoma, connected enhancer‐promoter function‐related phenotypes at . Additionally, higher allele frequencies protective detected LLFS than ALFA‐Europeans TOPMed, suggesting better function healthy‐aging general populations. Integrating genomic annotation transcriptional gene activity revealed enrichment elements aging‐ related processes. The expressions suggest their underlying shared effects highlight roles kidney‐ aging‐related signaling pathways.

Язык: Английский

A methodology for gene level omics-WAS integration identifies genes influencing traits associated with cardiovascular risks: the Long Life Family Study

Human Genetics, Год журнала: 2024, Номер unknown

Опубликована: Сен. 14, 2024

Язык: Английский

Circulating small non-coding RNA profiling for identification of older adults with low muscle strength and physical performance: A preliminary study

Experimental Gerontology, Год журнала: 2024, Номер 197, С. 112598 - 112598

Опубликована: Окт. 1, 2024

Small non-coding RNAs (ncRNAs) have recently emerged as potential biomarkers of sarcopenia. However, previous studies rarely explored the association small ncRNAs with sarcopenic components, especially muscle strength and physical performance. We aimed to examine circulating ncRNA profiles detect low performance in older adults.

Язык: Английский