Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Aging biomarkers quantify aging progression and provide actionable targets for therapeutic interventions to mitigate age-related decline. This review synthesizes emerging evidence on testicular biomarkers, focusing cellular senescence (Leydig, Sertoli, endothelial cells), protein homeostasis disruption, mitochondrial dysfunction, germ stem cell depletion, sperm telomere length, epigenetic alterations, oxidative stress, inflammation, gut microbiota dysbiosis. We propose that serves as a critical nexus linking reproductive decline with systemic processes, its pathological being quantifiable through specific including the Leydig, cells, INSL3, ribosomal RPL39L, relative length translocator protein, sialic acid. By bridging paradigms testis-specific mechanisms, we emphasize urgency identify organ-selective targeted interventions, advancing strategies preserve male fertility address population challenges.

Язык: Английский