The maltreated eco-phenotype of eating disorders: A new diagnostic specifier? A systematic review of the evidence and comprehensive description

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 160, С. 105619 - 105619

Опубликована: Март 9, 2024

This systematic review aimed to summarize the evidence on existence of a distinct phenotypic expression Eating Disorders (EDs) associated with childhood maltreatment (CM), so-called maltreated eco-phenotype EDs. PRISMA standards were followed. Articles providing data about characteristics individuals an ED reporting CM included. Relevant results extracted and summarized. A quality assessment was performed. total 1207 records identified screened, 97 articles published between 1994 2023 Findings revealed biological clinical features in patients EDs CM, including neuroanatomical changes, altered stress responses, ghrelin levels, inflammation markers, gut microbiota composition. Clinically, correlated severer eating behaviors, higher psychiatric comorbidity, impulsivity, emotional dysregulation, risky behaviors. Additionally, poorer treatment outcomes, especially general psychopathology comorbidities. highlighted need move towards etiologically informed nosography, recognizing not merely as risk factor, but also etiologic agent shaping different eco-phenotypic variants

Язык: Английский

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Childhood trauma and depressive symptoms in bipolar disorder: A network analysis

Acta Psychiatrica Scandinavica, Год журнала: 2023, Номер 147(3), С. 286 - 300

Опубликована: Янв. 16, 2023

Abstract Background Childhood trauma is related to an increased number of depressive episodes and more severe symptoms in bipolar disorder. The evaluation the networks symptoms—or patterns relationships between individual symptoms—among people with disorder without a history childhood may assist further clarifying this complex relationship. Methods Data from over 500 participants Heinz C. Prechter Longitudinal Study Bipolar Disorder were used construct series regularised Gaussian Graphical Models. symptoms—self‐reported (Patient Health Questionnaire—9; n = 543) clinician‐rated (Hamilton Depression Rating Scale—17; 529)—among (Childhood Trauma Questionnaire) characterised compared. Results Across sets networks, depressed mood consistently emerged as central symptom (as indicated by strength centrality expected influence); regardless participants' trauma. Additionally, feelings worthlessness key network self‐reported among with—but not without—a Conclusion present analyses—although exploratory—provide nuanced insights into impact on presentation disorder, which have potential aid detection inform targeted intervention development.

Язык: Английский

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Cohort Profile Update: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder

International Journal of Epidemiology, Год журнала: 2023, Номер 52(6), С. e324 - e331

Опубликована: Авг. 4, 2023

Journal Article Cohort Profile Update: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder Get access Anastasia K Yocum, Yocum Department Psychiatry, University Michigan, Ann Arbor, MI, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Steve Anderau, Anderau Holli Bertram, Bertram Helen J Burgess, Burgess Amy L Cochran, Cochran Mathematics and Population Health Sciences, Wisconsin, Madison, WI, https://orcid.org/0000-0001-6024-796X Patricia Deldin, Deldin USADepartment Psychology, Simon Evans, Evans Phenome Health, Seattle, WA, Peisong Han, Han Biostatistics, Paul M Jenkins, Jenkins Pharmacology, Ravleen Kaur, Kaur ... Show more Scott A Langenecker, Langenecker Utah, Salt Lake, UT, David F Marshall, Marshall Emily Mower Provost, Provost Computer Science Engineering, Sue O'Shea, O'Shea Cell Developmental Biology, Kelly Ryan, Ryan Sarah H Sperry, Sperry Shawna N Smith, Smith Management Policy, School Public Ivy Tso, Tso Kritika Versha, Versha Brittany Wright, Wright Sebastian Zöllner, Zöllner Melvin G McInnis Corresponding author. Psychiatry Eisenberg Family Depression Center, Michigan Medicine, 4152 Plymouth Road, MI 48109, USA. E-mail: [email protected] https://orcid.org/0000-0002-0375-6247 International Epidemiology, Volume 52, Issue 6, December 2023, Pages e324–e331, https://doi.org/10.1093/ije/dyad109 Published: 04 August 2023 history Received: 10 March 2022 Editorial decision: 02 June Accepted: 24 July

Язык: Английский

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Effect of Adverse Childhood Experiences, Parenting Styles, and Family Accommodation on Patients Diagnosed with Obsessive-Compulsive Disorder

ALPHA PSYCHIATRY, Год журнала: 2024, Номер 24(6), С. 261 - 269

Опубликована: Янв. 4, 2024

Obsessive-compulsive disorder (OCD) is a mental illness that has multiple biological, psychological, and sociological factors. The aim of this study was to investigate childhood traumatic experiences, parenting style, family adaptive behaviors in patients with OCD, explore the psychosocial factors affect its occurrence, analyze correlation between these OCD symptoms better understand etiology. We recruited 109 diagnosed (patient group) 144 healthy controls (control into study. Obsessive-Compulsive Inventory-Revised (OCI-R), Childhood Trauma Questionnaire-Short Form (CTQ-SF), Egna Minnen Betraffande Uppfostran (EMBU), Family Accommodation Scale-Patient Version (FAS-PV) questionnaires were administered all participants. Patient OCI-R scores for checking, hoarding, obsessing, ordering, washing, neutralizing, total significantly higher when compared control group (all P < .05). CTQ emotional abuse, physical sexual neglect, Patients' EMBU F1, F2, F3, F5, F6, M1, M2, M3, M4, M5, There no significant difference F4 2 groups (P = .622). FAS-PV direct participation facilitation symptoms, avoidance triggers, taking on patient responsibilities, modification personal score showed positive (r 0.564; r 0.518; 0.542; 0.586; 0.603, 0.504; 0.531; 0.611; 0.466; 0.519; 0.665; 0.351; 0.597; 0.667; 0.484; 0.662, facilitation, 0.571; 0.624; 0.670; 0.592; 0.684, Our findings highlight importance adverse styles, accommodation patients. Importantly, experiences are closely related severity suggest not only physiological, changes play crucial role occurrence development OCD. This confirmed an important education greatly affects Therefore, it can be inferred good psychological effect reducing risk If included community medical services, will help mitigate health situations.

Язык: Английский

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Self-concept mediates the relationships between childhood traumatic experiences and adolescent depression in both clinical and community samples

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Март 26, 2024

Abstract Background Childhood trauma is a pivotal risk factor for adolescent depression. While the association between childhood and depression well-established, mediating role of self-concept has not been acknowledged. Specifically, limited attention paid to how maltreatment impacts through physical social self-concept, both in clinical community samples. This study aims investigate distinct cumulative affects depression, as well potential their relationships. Methods We recruited 227 depressed adolescents (dataset 1, 45 males, age = 15.34 ± 1.96) 574 2, 107 16.79 0.65). Each participant was assessed on five subtypes severity, index, Mediation models were tested separately Results Clinically experienced higher level greater number subtypes, had lower levels compared adolescents. Analyses severity index jointly indicated that played mediation roles relationships experiences Moreover, effects stronger when Conclusions Our findings suggest play pathway linking particularly clinically individuals.

Язык: Английский

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Comorbidity of anxiety and depression disorder among clinical referral patients: a longitudinal study based on network analysis

Current Psychology, Год журнала: 2024, Номер 43(23), С. 20655 - 20667

Опубликована: Апрель 1, 2024

Язык: Английский

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Understanding the relationship between childhood abuse and affective symptoms in bipolar disorder: new insights from a network analysis

Psychiatry Research, Год журнала: 2024, Номер 342, С. 116197 - 116197

Опубликована: Сен. 16, 2024

Язык: Английский

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The effect of childhood trauma on bipolar depression

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 7, 2025

Childhood trauma (CT) is associated with an earlier onset and a more severe course of bipolar disorder (BD). However, the specific impact CT on depression remains unclear. Herein, this study aimed to investigate effect using depressive episode frequency as threshold for disease burden severity. A cohort 146 participants BD was followed 3 years. The effects mood episodes, hospital readmissions, suicidal ideation, behavior were analyzed. high number episodes identified in exposure, being pronounced II than I. ≥4 serves sensitivity cutoff point detect associations outcomes, such early readmission ideation behavior. presence increases risk experiencing at least one outcome by 80%. In our cohort, mediated (early or behavior). limited its non-probabilistic sample, recall bias, moderate receiver operating characteristic curve value. findings reinforce association between severity, highlighting significantly higher individuals CT. This underscores factor predominant polarity frequent BD.

Язык: Английский

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The development of depressive symptoms in subthreshold depression adolescents with a history of childhood maltreatment: A longitudinal network analysis

Journal of Affective Disorders, Год журнала: 2025, Номер unknown, С. 119389 - 119389

Опубликована: Май 1, 2025

Язык: Английский

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A Transdiagnostic Network Analysis of Childhood Trauma and Psychopathology

Schizophrenia Bulletin, Год журнала: 2024, Номер unknown

Опубликована: Авг. 16, 2024

Psychiatric comorbidities suggest that symptoms overlap across different diagnoses; the transdiagnostic network approach is valuable for studying psychopathology. Childhood trauma a common risk factor psychiatric disorders, but complex relationship between childhood and psychopathology has seldom been investigated using large cross-sectional sample.

Язык: Английский

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