Psychiatry and Clinical Psychopharmacology, Год журнала: 2023, Номер 33(3), С. 229 - 237
Опубликована: Сен. 1, 2023
Gray matter alterations play a role in the panic disorder's pathophysiology origin. However, current literature seemed inadequate to reach consistent conclusion. Therefore, we conducted this gray meta-analysis on disorder.
Язык: Английский
Molecular Autism, Год журнала: 2024, Номер 15(1)
Опубликована: Апрель 4, 2024
Abstract Background This meta-analysis aimed to explore the most robust findings across numerous existing resting-state functional imaging and voxel-based morphometry (VBM) studies on structural brain alterations in individuals with autism spectrum disorder (ASD). Methods A whole-brain voxel-wise was conducted compare differences intrinsic activity gray matter volume (GMV) between ASD typically developing (TDs) using Seed-based d Mapping software. Results total of 23 (786 ASD, 710 TDs) 52 VBM (1728 1747 were included. Compared TDs, displayed decreases left insula (extending superior temporal gyrus [STG]), bilateral anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC), angular right inferior gyrus, as well increases supplementary motor area precuneus. For meta-analysis, decreased GMV ACC/mPFC cerebellum, increased middle STG), olfactory cortex, precentral gyrus. Further, after overlapping differences. Conclusions The present multimodal demonstrated that exhibited similar both function structure ACC/mPFC, or default mode network (DMN), primary sensory regions. These contribute further understanding pathophysiology ASD.
Язык: Английский
Процитировано
28
Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102240 - 102240
Опубликована: Фев. 22, 2024
Язык: Английский
Процитировано
23
Med, Год журнала: 2024, Номер 5(3), С. 201 - 223.e6
Опубликована: Фев. 14, 2024
Язык: Английский
Процитировано
12
Translational Psychiatry, Год журнала: 2024, Номер 14(1)
Опубликована: Июль 16, 2024
Abstract Accumulating evidence has revealed the gut bacteria dysbiosis and brain hippocampal functional structural alterations in major depressive disorder (MDD). However, potential relationship between microbiota function patients with MDD is still very limited. Data of resting-state magnetic resonance imaging were acquired from 44 unmedicated 42 demographically matched healthy controls (HCs). Severn pairs hippocampus subregions (the bilateral cornu ammonis [CA1-CA3], dentate gyrus (DG), entorhinal cortex, hippocampal–amygdaloid transition area, subiculum) selected as seeds connectivity (FC) analysis. Additionally, fecal samples participants collected 16S rDNA amplicon sequencing was used to identify altered relative abundance microbiota. Then, association analysis conducted investigate relationships abnormal FC microbiome features. Also, subregion values levels features separately or together support vector machine models distinguishing HCs. Compared HCs, exhibited increased left (CA2, CA3 DG) right (CA2 CA3), decreased posterior cingulate cortex. In addition, we found that level proinflammatory (i.e., Enterobacteriaceae ) significantly increased, whereas short-chain fatty acids producing-bacteria Prevotellaceae, Agathobacter Clostridium patients. Furthermore, CA3- CA3) positively correlated MDD. Moreover, patterns considered combination, best discrimination obtained (AUC = 0.92). These findings may provide insights into role underlying neuropathology
Язык: Английский
Процитировано
9
NeuroImage, Год журнала: 2024, Номер 292, С. 120604 - 120604
Опубликована: Апрель 1, 2024
Despite its widespread use, resting-state functional magnetic resonance imaging (rsfMRI) has been criticized for low test-retest reliability. To improve reliability, researchers have recommended using extended scanning durations, increased sample size, and advanced brain connectivity techniques. However, longer runs larger sizes may come with practical challenges burdens, especially in rare populations. Here we tested if an technique, dynamic causal modeling (DCM), can reliability of fMRI effective (EC) metrics to acceptable levels without extremely long run durations or large samples. Specifically, employed DCM EC analysis on rsfMRI data from the Human Connectome Project. avoid bias, assessed four distinct DCMs gradually a randomized manner across ten permutations. We pseudo true positive false rates assess efficacy shorter (3.6, 7.2, 10.8, 14.4 minutes) replicating outcomes longest duration (28.8 min) when size was fixed at largest (n=160 subjects). Similarly, smaller (n=10, 20, …, 150 subjects) min). Our results revealed that rate below 0.05 all analyses. After reached 10.8 minutes, which yielded 92%, further extensions time showed no improvements rate. Expanding led enhanced outcomes, plateau n=70 subjects targeted top one-half ECs reference sample, regardless whether viable (10.8 employed. Encouragingly, exhibited approximately 80% n=20, 90% n=40 subjects. These suggest be option attain reliable times are not feasible.
Язык: Английский
Процитировано
5
Frontiers in Psychiatry, Год журнала: 2024, Номер 15
Опубликована: Авг. 23, 2024
Background Previous studies based on resting-state functional magnetic resonance imaging(rs-fMRI) and voxel-based morphometry (VBM) have demonstrated significant abnormalities in brain structure activity patients with early-onset schizophrenia (EOS), compared healthy controls (HCs), these alterations were closely related to the pathogenesis of EOS. However, previous suffer from limitations small sample sizes high heterogeneity results. Therefore, present study aimed effectively integrate identify common specific structural Methods The PubMed, Web Science, Embase, Chinese National Knowledge Infrastructure (CNKI), WanFang databases systematically searched publications regional gray matter volume (GMV) Then, we utilized Seed-based d Mapping Permutation Subject Images (SDM-PSI) software conduct a whole-brain voxel meta-analysis VBM rs-fMRI studies, respectively, followed by multimodal overlapping this basis comprehensively Results A total 27 original (28 datasets) included meta-analysis, including 12 (13 (496 EOS patients, 395 HCs) 15 (15 GMV (458 531 HCs). Overall, showed significantly increased left middle frontal gyrus (extending triangular part inferior gyrus) right caudate nucleus. On other hand, decreased superior temporal rolandic operculum), gyrus, pole (superior gyrus). Conclusion This revealed that some regions exhibited or abnormalities, such as gyri, prefrontal cortex, striatum. These findings may help deepen our understanding underlying pathophysiological mechanisms provide potential biomarkers for diagnosis treatment
Язык: Английский
Процитировано
3
Child Neuropsychology, Год журнала: 2025, Номер unknown, С. 1 - 21
Опубликована: Янв. 17, 2025
The current study investigated the relationship between adverse childhood experiences (ACEs), post-traumatic stress disorder (PTSD) symptoms, within-network resting-state functional connectivity (rs-FC), and alcohol use during adolescence using magnetic resonance imaging (fMRI) data from National Consortium on Alcohol Neurodevelopment in Adolescence (NCANDA; N = 687). Significant rs-FC differences emerged that linked participant ACEs, PTSD problems. Participants with ACEs compared to those without had diminished within default mode, salience, medial frontoparietal networks (p ≤ 0.005). Further reduction mode 0.005) was found when symptoms were present addition ACEs. Findings suggest are associated lower network beyond exposure some of these changes worsened problems (i.e. withdrawal symptoms). These findings highlight importance addressing adolescents a history as it may mitigate problematic brain reduce risk developing
Язык: Английский
Процитировано
0
Psychiatry Research Neuroimaging, Год журнала: 2025, Номер 348, С. 111959 - 111959
Опубликована: Янв. 29, 2025
Язык: Английский
Процитировано
0
Frontiers in Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Фев. 5, 2025
Objectives Neuroimaging investigations into chronic low back pain (CLBP) have detected functional abnormalities across a spectrum of brain regions, yet the findings often been inconsistent. In this meta-analysis, we integrated existing data, delineating pattern coherent results from encompassed studies. Methods A systematic search neuroimaging studies investigating activity differences between CLBP and Healthy controls (HCs) was conducted in seven databases up to December 22, 2024. An anisotropic effect-size signed differential mapping (AES-SDM)-based meta-analysis carried out report perform multimodal analysis. Results total 20 publications reporting on 24 experiments meta-analysis. The ReHo showed abnormal spontaneous left inferior temporal gyrus (ITG), superior frontal (SFG), right middle (MFG), precuneus, fusiform bilateral postcentral (PoCG) patients. ALFF demonstrated alterations rolandic operculum (extending insula IFG), ITG, occipital (MOG), paracentral lobule, PoCG cuneus cortex group revealed that patients with displayed new decreased thalamus, precentral (PreCG) lingual gyrus. Conclusion Patients exhibit extensive abnormalities, involving regions related perception, emotional processing, cognitive functions, both visual motor cortices. These might provide valuable reference for identification potential therapeutic targets brain.
Язык: Английский
Процитировано
0
BMC Psychiatry, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 27, 2025
Recent genome-wide association studies have linked voltage-gated calcium channel genes to bipolar disorder (BD), in which CACNB2 gene rs11013860 is respectively reported. Less known, though, about how precisely its polymorphism affects both the structure and function of brain. 173 BD patients 207 healthy controls (HCs) were underwent structural functional magnetic resonance imaging scan genotyped for rs11013860. Grey matter volume (GMV), regional homogeneity (ReHo) degree centrality (DC) used examine brain structure, activity connectivity these participants. The emotional circuits patients, such as cerebellum, insula, cingulate gyrus, fusiform superior frontal / middle temporal occipital lingual precuneus, putamen, hippocampus parahippocampal main areas where GMV, ReHo, DC differed from HCs. And right anterior posterior cerebellar lobes, gyrus well showed an interaction between genotypes diagnoses GMV. In addition, there was a significant step-wise increase GMV with decreased dosage A risk allele HCs, but this pattern relationship absent patients. No found ReHo DC. These results suggest that may be associated abnormalities cerebellar, limbic system other regions, perhaps contributing disease.
Язык: Английский
Процитировано
0