CRMP2 in the hippocampus alleviates chronic stress-induced depressive-like behaviours in mice by affecting synaptic function

Behavioural Brain Research, Год журнала: 2025, Номер 484, С. 115495 - 115495

Опубликована: Фев. 26, 2025

Язык: Английский

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Effectiveness of pharmacological and non-pharmacological interventions for treatment-resistant depression in older patients: a systematic review and meta-analysis

BMJ Mental Health, Год журнала: 2025, Номер 28(1), С. e301324 - e301324

Опубликована: Март 1, 2025

Background Depression in older adults is often undertreated. A 2011 systematic review of treatments for treatment-resistant depression (TRD) identified one placebo-controlled randomised controlled trial (RCT). We aimed to update this review, synthesising evidence the effectiveness TRD people. Methods systematically searched electronic databases (PubMed, Cochrane, Web Science) from 9 January through 10 December 2023 (updating our search on 7 2024 RCTs investigating therapies aged ≥55 years, defining treatment resistance as ≥1 unsuccessful treatment. assessed bias with Cochrane Risk Bias (RoB) 2 tool, meta-analysed remission rates and evaluated using GRADE (Grading Recommendations Assessment, Development, Evaluation) criteria. Results 14 studies (11 newly identified, 3 previous review) involving 1196 participants (mean age 65.0, male/female 548/648) met inclusion criteria; were placebo 4 rated low RoB. The pooled proportion intervention arms remitting was 0.35 (17 arms; 95% CI=0.26; 0.45). Relative placebo, more likely remit (9 studies; OR 2.42 (95% CI=1.49; 3.92)). controls, favoured ketamine (n=3; 2.91 (1.11; 7.65)), a trend towards transcranial magnetic stimulation (TMS) 1.99 (0.71; 5.61)), single studies, selegiline, aripiprazole augmentation, pharmacogenetic-guided prescribing (PGP) cognitive remediation interventions. Conclusions weak that therapy very TMS, PGP increased remission. Lack regarding routinely prescribed antidepressants psychosocial problematic, requiring clinicians extend younger populations. PROSPERO registration number CRD42023494513.

Язык: Английский

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High-performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 27, 2025

Introduction The incidence and mortality rate from depression are increasing year by year, has become the main cause of global health loss disability. Currently, treatment mainly relies on drug intervention. However, vast majority antidepressants exhibit significant pharmacological variability, resulting in individual differences steady-state blood concentrations even with same dosing regimen among patients. Therefore, using therapeutic monitoring (TDM) to guide precise use important clinical significance. Methods In this paper, we developed a high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method study simultaneously TDM pharmacokinetics 23 active metabolites: sertraline, escitalopram, fluvoxamine, paroxetine, duloxetine, milnacipran, fluoxetine, venlafaxine, O-desmethylvenlafaxine, mirtazapine, trazodone, bupropion, hydroxybupropione, norfluoxetine, vortioxetine, agomelatine, mianserin, doxepine, desmethyldoxepin, clomipramine, desmethylclomipramine, amitriptyline nortriptyline hydrochloride. After protein precipitation serum samples acetonitrile, isotope internal standards (ISs), metabolites were separated ZORBAX Eclipse Plus C18 column (50.0 mm × 2.1 mm, 1.7 µm) water containing 0.1% formic acid 10 mmol/L ammonium acetate methanol acid. Validation was carried out based Chinese Pharmacopoeia guidelines for bioanalytical validation, including assessment specificity, calibration curves, carryover, accuracy, crosstalk, precision, stability, recovery, dilution integrity matrix effect. Results results showed that simple, fast, reliable specific HPLC'MS/MS validated, all performance characteristics met requirements, which could be used above metabolites.

Язык: Английский

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Effects and neural mechanisms of different physical activity on major depressive disorder based on cerebral multimodality monitoring: a narrative review

Frontiers in Human Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Авг. 12, 2024

Major depressive disorder (MDD) is currently the most common psychiatric in world. It characterized by a high incidence of disease with symptoms like depressed mood, slowed thinking, and reduced cognitive function. Without timely intervention, there 20–30% risk conversion to treatment-resistant depression (TRD) burden for patient, family society. Numerous studies have shown that physical activity (PA) non-pharmacological treatment can significantly improve mental status patients MDD has positive effects on function, sleep status, brain plasticity. However, physiological psychological different types PA individuals vary, dosage profile improving not been elucidated. In current MDD, be categorized as continuous endurance training (ECT), explosive interval (EIT), resistance strength (RST), mind–body (MBT), patients’ symptoms, varied. Therefore, present study was based narrative review included large number existing investigate characteristics differences interventions MDD. The also investigated explained neural mechanisms through results multimodal function monitoring, including intracranial environment structure. aims provide exercise prescription theoretical reference future research neuroscience clinical intervention

Язык: Английский

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A multicenter, retrospective study of the current status of antidepressant prescription use in outpatient settings in China

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 13, 2024

Background: Antidepressant prescribing has increased dramatically worldwide in recent years. Analyzing antidepressants real-world settings can provide valuable data to support clinicians and health policymakers. Aim: This study used an extensive set examine the status trends antidepressant among Chinese Han population from July 1, 2017, June 30, 2022. Method: A retrospective was conducted three hospitals. Data were collected 2.5 years before after onset of COVID-19 pandemic. We analyzed number patients diagnosed with depression corresponding prescriptions. To explore characteristics use across different ages sexes, stratified analyses performed using chi-square test. Results: The included 124,355 patients, 400,840 prescriptions collected. Fluctuating upward observed drugs. The most frequently prescribed citalopram, escitalopram, sertraline. Significant differences by sex age. pandemic 37.1% compared pre-pandemic period, rose 88.3%. Antidepressant monotherapy represented 76.6% common combination involved anxiolytics. Conclusion: Over past five years, shown trends. Citalopram, sertraline are currently leading outpatient treatment depressive disorders. significantly affected clinic visits for depression.

Язык: Английский

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A target trial emulation comparing the antidepressant effectiveness of selective serotonin reuptake inhibitors (SSRIs) highlighting the importance of patent‐related confounding by indication

Acta Psychiatrica Scandinavica, Год журнала: 2024, Номер 150(4), С. 198 - 208

Опубликована: Июль 12, 2024

The comparative effectiveness of selective serotonin reuptake inhibitors (SSRIs) has been subjected to relatively little research. However, a recent study based on target trial emulation suggested that sertraline may be more effective than escitalopram.

Язык: Английский

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