The comparative evidence of efficacy of non-invasive brain and nerve stimulation in diabetic neuropathy: a systematic review and network meta-analysis

Journal of NeuroEngineering and Rehabilitation, Год журнала: 2025, Номер 22(1)

Опубликована: Апрель 19, 2025

Abstract Background Diabetes mellitus is a highly burdensome metabolic disorder, affecting over 100 million people worldwide and leading to numerous complications. Among these, diabetic neuropathy one of the most common, with approximately 60% individuals diabetes developing this condition. Current pharmacological treatments for are often inadequate, providing limited efficacy accompanied by range adverse effects. Non-invasive brain nerve stimulation techniques have been proposed as potentially beneficial neuropathy, though existing evidence remains inconclusive. This systematic review network meta-analysis (NMA) aimed evaluate comparative various non-invasive interventions in patients neuropathy. Methods A search electronic databases was conducted identify randomized controlled trials (RCTs) or from inception September 6, 2024. The primary outcome change pain severity, while secondary outcomes included changes quality life sleep disturbance. Acceptability assessed through dropout rates (i.e., withdrawal study before completion any reason). frequentist-based NMA performed, utilizing odds ratios (OR) standardized mean differences (SMD) 95% confidence intervals (95%CIs) effect size measures. Results NMA, which 15 RCTs (totaling 1,139 participants, age 61.2 years female proportion 53.8%), evaluated 10 experimental (1 control group, 4 methods, 5 methods). analysis revealed that only transcutaneous electrical (TENS) associated significantly greater improvements severity (SMD = − 1.67, 95%CIs 2.64 0.71) disruption 1.63, 2.27 0.99) compared group. None studied showed significant all-cause mortality Conclusion provides supporting use specific managing Future well-designed longer treatment durations recommended further validate long-term these interventions. Trial registration PROSPERO CRD42024587660.

Язык: Английский

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A network meta-analysis of non-invasive brain stimulation interventions for autism spectrum disorder: Evidence from randomized controlled trials

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 164, С. 105807 - 105807

Опубликована: Июль 7, 2024

The efficacy and acceptability of various non-invasive brain stimulation (NIBS) interventions for autism spectrum disorder remain unclear. We carried out a systematic review randomized controlled trials (RCTs) regarding NIBS reducing autistic symptoms (INPLASY202370003). Sixteen articles (N = 709) met the inclusion criteria network meta-analysis. Effect sizes were reported as standardized mean differences (SMDs) or odds ratios with 95 % confidence intervals (CIs). Fourteen active interventions, including transcranial direct current (tDCS), repetitive magnetic stimulation, pulse analyzed. Only anodal tDCS over left dorsolateral prefrontal cortex paired cathodal an extracephalic location (atDCS_F3 + ctDCS_E) significantly improved compared to sham controls (SMD - 1.40, %CIs 2.67 0.14). None markedly social-communication restricted/repetitive behaviors in participants. Moreover, no exhibited significant dropout rate controls, serious adverse events any intervention.

Язык: Английский

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Early efficacy of rTMS intervention at week 2 predicts subsequent responses at week 24 in schizophrenia in a randomized controlled trial

Neurotherapeutics, Год журнала: 2024, Номер 21(5), С. e00392 - e00392

Опубликована: Июнь 29, 2024

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain technique for modulating cortical activities and improving neural plasticity. Several studies investigated the effects of rTMS, etc., but results are inconsistent. This study was designed to examine whether rTMS applied on left dorsolateral prefrontal cortex (l-DLPFC) showed an effect cognitive deficits in SZ early efficacy could predict at subsequent follow-ups. Cognitive ability assessed using Repeatable Battery Assessment Neuropsychological Status (RBANS) scale baseline, weeks 2, 6, 24. We found significant interaction between time (weeks 0, 24) intervention immediate memory RBANS total scores (p ​= ​0.02 p ​0.04), indicating that both 10-Hz 20-Hz stimulations had delayed beneficial SZ. Moreover, we stimulation, not improved week 6 compared sham group ​0.029). More importantly, improvements 2 were positively correlated with 24 (β ​0.461, t ​3.322, ​0.002). Our suggests active patients Furthermore, 24-week follow-up.

Язык: Английский

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Neuromodulation treatments for post-traumatic stress disorder: A systematic review and network meta-analysis covering efficacy, acceptability, and follow-up effects

Journal of Anxiety Disorders, Год журнала: 2024, Номер 106, С. 102912 - 102912

Опубликована: Июль 28, 2024

Язык: Английский

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