Epigenomics, Год журнала: 2023, Номер 15(1), С. 5 - 10
Опубликована: Янв. 1, 2023
Язык: Английский
PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0303038 - e0303038
Опубликована: Фев. 5, 2025
The co-occurrence of alcohol use disorder (AUD) and schizophrenia is prevalent, with a rate 33.7%. Previous research has suggested genetic epigenetic overlap between these two disorders. SSTR4 , member the somatostatin receptor family, implicated in various neurological psychiatric conditions, including cognitive function, AUD, schizophrenia. However, role genetic-epigenetic interactions involving patients remains unexplored. In this study, we conducted an integration publicly available datasets identified allele-specific methylation patterns SSTR4. Additionally, pinpointed several variants (rs17691954, rs11464356, rs3109190, rs145879288) that influence pace aging functions (rs705935) through their quantitative trait loci effects on CpG sites within .
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1623 - 1623
Опубликована: Фев. 14, 2025
Alcohol use disorder (AUD) contributes significantly to the global burden of disease. The susceptibility for AUD is mediated through an interaction genetic risk factors and environmental influences. These gene × environment (G E) interactions manifest as epigenetic regulations expression, among other things. Previous research suggests association between Ganglioside Induced Differentiation Associated Protein 1 (GDAP1) DNA methylation AUD. Here, we investigate dysregulation GDAP1 in comparing whole blood saliva, well H3K4-trimethylation (H3K4me3) PBMC (Peripheral Blood Mononuclear Cell) samples patients healthy control individuals. Additionally, effect abstinence-based therapy was investigated. before treatment exhibit lower promoter levels H3K4me3 near transcription start site. expression not altered. Following treatment, increased no longer differed from There significant on methylation. We conclude that epigenetically dysregulated patients, responsive at level H3K4me3. It should be investigated further establish its potential a diagnostic biomarker.
Язык: Английский
Процитировано
0
American Journal of Psychiatry, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
The authors provide recommendations on incorporating recent advances in psychiatric genetics into clinical practice for mental health clinicians. International Society Psychiatric Genetics Education Committee met monthly to come a consensus priority topics genetics. Topics were then assigned small teams of subspecialty experts summarize the current knowledge base and create an illustrative case. included, familial aggregation, common rare genetic variants, epigenetics, gene-environment interactions, pharmacogenomics, counseling, ethical social implications. Each section was reviewed revised by all committee members finalized Chair. Key findings highlight importance understanding architecture disorders, potential applications information risk assessment, diagnosis, treatment selection, patient education, as well considerations surrounding use data. emphasizes need nuanced approach that integrates factors with environmental experiential holistic model care. As continues evolve rapidly, clinicians must stay informed about latest their Ongoing collaboration professionals, effective communication strategies are crucial harness power while avoiding pitfalls such determinism stigma. recommends balanced perspective recognizes complex interplay non-genetic shaping outcomes.
Язык: Английский
Процитировано
0
Alcohol Clinical and Experimental Research, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
Abstract Background Chronic heavy alcohol use is a major risk factor for premature aging and age‐related diseases. DNA methylation (DNAm)‐based epigenetic clocks are novel tools predicting biological age. However, the newest configurations, causality‐enriched clocks, have not been assessed in context of consumption disorder (AUD). Methods Epigenetic was evaluated sample 615 individuals (372 AUD patients 243 healthy controls) by applying GrimAge Version 1 (V1) 2 (V2) alongside three (CausAge, DamAge, AdaptAge). A linear model controlling diagnosis, sex, race, BMI, smoking status, five blood cell types leveraged to test associations between alcohol‐related metrics age‐adjusted clocks. Results V1 V2 maintained significant with drinking behavior measures within total both young (<40 years old) old (≥40 subgroups. Generally, slightly outperformed V1, while none demonstrated AUD. subgroup, DamAge had association number drinks. Across age subgroups, liver function enzymes, consistently sustained stronger compared V1. Among fourth‐generation exhibited gamma‐glutamyl transferase (GGT) aspartate aminotransferase subgroup; CausAge displayed GGT sample. Examining clinical biomarkers, showed improved C‐reactive protein Conclusions Overall, we observed moderately performance majority parameters tested. The lacked but demonstrate complexities inspire further research dynamics.
Язык: Английский
Процитировано
0
Frontiers in Behavioral Neuroscience, Год журнала: 2023, Номер 17
Опубликована: Янв. 26, 2023
Alcohol use disorder (AUD) is a worldwide problem. Unfortunately, the molecular mechanisms of alcohol misuse are still poorly understood, therefore successful therapeutic approaches limited. Accumulating data indicate that tendency for compulsive inherited, suggesting genetic background as an important factor. However, probability to develop AUD also affected by life experience and environmental factors. Therefore, epigenetic modifications altered over lifetime likely contribute increased risk misuse. Here, we review literature looking link between DNA methylation in brain, common modification, AUD-related behaviors humans, mice rats. We sum up main findings, identify existing gaps our knowledge future directions research.
Язык: Английский
Процитировано
6
Expert Opinion on Pharmacotherapy, Год журнала: 2022, Номер 23(10), С. 1181 - 1193
Опубликована: Май 31, 2022
Comorbidity of bipolar disorder (BD) and alcohol use (AUD) is very frequent resulting in detrimental outcomes, including increased mortality. Diagnosis AUD BD vice versa often delayed as symptoms one mimic obscure the other one. Evidence for pharmacotherapies people with comorbid remains limited, further proof-of-concept studies are urgently needed.This paper explores currently available AUD, their usefulness AUD. It also covers to some degree epidemiology, diagnosis, potential common neurobiological traits AUD.The authors conclude that more controlled needed before evidence-based guidance can be drawn up clinician's use. Since there no relevant pharmacological interactions, approved medications used safely BD. For mood stabilization, lithium should considered first adherent persons Alternatives include valproate, lamotrigine, atypical antipsychotics, partial D2/D3 receptor agonism possibly being beneficial too.
Язык: Английский
Процитировано
8
Epigenomics, Год журнала: 2022, Номер 14(12), С. 793 - 810
Опубликована: Июнь 1, 2022
Aim: We systematically reviewed and evaluated current literature on alcohol consumption DNA methylation (DNAm) at the genome-wide probe-wise level in blood of adults. Materials & methods: Five databases (PubMed, Embase, Web Science, CINAHL PsycInfo) were searched until 20 December 2020. Studies assessing effect dependence DNAm not eligible. Results: 11 cross-sectional studies included with 88 to 9643 participants. Overall, all had a risk bias criteria unclear or unmet. Epigenome-wide association identified between 0 5458 differentially methylated positions, 15 observed least four studies. Conclusion: Potential markers for have been identified, but further validation large cohorts is needed.
Язык: Английский
Процитировано
8
Current Pharmaceutical Design, Год журнала: 2023, Номер 29(27), С. 2124 - 2139
Опубликована: Июль 7, 2023
Abstract: Currently, and globally, we are facing the worst epidemic of psychoactive drug abuse resulting in loss hundreds thousands lives annually. Besides alcohol opioid use misuse, there has been an increase illicit psychostimulants. Epigenetics is a relatively novel area research that studies heritable alterations gene expression. Long-term administration drugs may lead to transcriptional changes brain regions related drug-seeking behaviors rewards can be passed down transgenerationally. Epigenetic biomarkers such as DNA methylation histone modifications contribute disease diagnoses. This review aims look at epigenetic brought forth by abuse.
Язык: Английский
Процитировано
4
Frontiers in Genetics, Год журнала: 2024, Номер 15
Опубликована: Апрель 3, 2024
Background: Alcohol use disorder (AUD) is a complex condition associated with adverse health consequences that affect millions of individuals worldwide. Epigenetic modifications, including DNA methylation (5 mC), have been AUD and other alcohol-related traits. Epigenome-wide association studies (EWAS) identified differentially methylated genes in human peripheral brain tissue. More recently, epigenetic also evaluated hydroxymethylation hmC) the brain. However, most work postmortem tissue has examined bulk In this study, we investigated neuronal-specific 5 mC hmC alterations at CpG sites orbitofrontal cortex (OFC). Methods: Neuronal nuclei from OFC were 34 samples (10 AUD, 24 non-AUD). Reduced representation oxidative bisulfite sequencing was used to assess genome-wide level. Differential using methylKit R package significance set false discovery rate < 0.05 differential > 2. Functional enrichment analyses performed, gene-level convergence an independent dataset assessed cortical Results: We 417 363 5hmC significant 59% gene promoters. Some previously implicated alcohol consumption, SYK, DNMT3A for mC, GAD1, DLX1, DLX2, GATA4 both. Convergence previous study observed 28 genes. 35 regions hmC, respectively. Lastly, GWAS analysis showed Discussion: This reveals methylome hydroxymethylome dysregulation identifying both reported potentially novel associations AUD. Our findings provide new insights into epigenomic
Язык: Английский
Процитировано
1
iScience, Год журнала: 2024, Номер 27(7), С. 110159 - 110159
Опубликована: Июнь 1, 2024
Alcohol use disorder (AUD) is a of clinical and public health significance requiring novel improved therapeutic solutions. Both environmental genetic factors play significant role in its pathophysiology. However, the underlying epigenetic molecular mechanisms that link gene-environment interaction AUD remain largely unknown. In this proof-of-concept study, we showed, for first time, neuroepigenetic biomarker capability non-invasive imaging class I histone deacetylase (HDAC) enzymes
Язык: Английский
Процитировано
1