The ReCoDe addiction research consortium: Losing and regaining control over drug intake—Findings and future perspectives
Addiction Biology,
Год журнала:
2024,
Номер
29(7)
Опубликована: Июль 1, 2024
Abstract
Substance
use
disorders
(SUDs)
are
seen
as
a
continuum
ranging
from
goal‐directed
and
hedonic
drug
to
loss
of
control
over
intake
with
aversive
consequences
for
mental
physical
health
social
functioning.
The
main
goals
our
interdisciplinary
German
collaborative
research
centre
on
Losing
Regaining
Control
Drug
Intake
(ReCoDe)
(i)
study
triggers
(drug
cues,
stressors,
priming)
modifying
factors
(age,
gender,
activity,
cognitive
functions,
childhood
adversity,
factors,
such
loneliness
contact/interaction)
that
longitudinally
modulate
the
trajectories
losing
regaining
consumption
under
real‐life
conditions.
(ii)
To
underlying
behavioural,
neurobiological
mechanisms
disease
drug‐related
behaviours
(iii)
provide
non‐invasive
mechanism‐based
interventions.
These
achieved
by:
(A)
using
innovative
mHealth
(mobile
health)
tools
monitor
effects
patterns
in
real
life
cohort
900
patients
alcohol
disorder.
This
approach
will
be
complemented
by
animal
models
addiction
24/7
automated
behavioural
monitoring
across
an
entire
trajectory;
i.e.
naïve
state
drug‐taking
or
resilience‐like
state.
(B)
identification
and,
if
applicable,
computational
modelling
key
molecular,
psychological
(e.g.,
reduced
flexibility)
mediating
trajectories.
(C)
Developing
testing
interventions
Just‐In‐Time‐Adaptive‐Interventions
(JITAIs),
various
brain
stimulations
(NIBS),
individualized
activity)
specifically
target
intake.
Here,
we
report
most
important
results
first
funding
period
outline
future
strategy.
Язык: Английский
Does compulsion explain addiction?
Addiction Biology,
Год журнала:
2024,
Номер
29(4)
Опубликована: Апрель 1, 2024
Abstract
One
of
the
leading
drug
addiction
theories
states
that
habits
and
underlying
neural
process
a
ventral
to
dorsal
striatal
shift
are
building
blocks
compulsive
drug‐seeking
behaviour
compulsion
is
maladaptive
persistence
responding
despite
adverse
consequences.
Here
we
discuss
as
defined
primarily
from
perspective
animal
experimentation
falls
short
clinical
phenomena
their
neurobiological
correlates.
Thus
for
human
condition,
concept
should
be
critically
addressed
potentially
revised.
Язык: Английский
The multiple faces of footshock punishment in animal research on addiction
Neurobiology of Learning and Memory,
Год журнала:
2024,
Номер
213, С. 107955 - 107955
Опубликована: Июнь 28, 2024
Continued
drug
use
despite
negative
consequences
is
a
hallmark
of
addiction
commonly
modelled
in
rodents
using
punished
intake.
Over
the
years,
research
highlighted
two
subpopulations
punishment
sensitive
and
resistant
animals.
While
helpful
to
interrogate
neurobiology
drug-related
behaviors,
these
procedures
carry
some
weaknesses
that
need
be
recognized
eventually
defused.
Mainly
focusing
on
footshock-related
work,
we
will
first
discuss
criteria
used
define
punishment-resistant
animals
how
their
relative
arbitrariness
may
impact
our
findings.
With
overarching
goal
improving
interpretation
phenotype,
evaluate
tailored
protocols
better
apprehend
resistance
punishment,
testing
robustness
could
yield
new
results
strengthen
interpretations.
Second,
question
whether
what
extent
sensitivity,
as
currently
defined,
reflective
abstinence
suggest
is,
fact,
prerequisite
model
from
addiction.
Again,
examine
challenging
punishment-sensitive
phenotype
help
characterize
it.
Finally,
diminished
relapse-like
behavior
after
repeated
punishment-induced
not
only
contribute
understand
mechanisms
abstinence,
but
also
uniquely
progressive
recovery
(i.e.,
failed
attempts
at
recovery)
which
norm
people
with
Altogether,
by
questioning
strengths
models,
would
like
open
discussions
different
ways
interpret
sensitivity
aspects
remain
explored.
Язык: Английский
Generative Artificial intelligence Addiction Syndrome: A New Behavioral Disorder?
Asian Journal of Psychiatry,
Год журнала:
2025,
Номер
unknown, С. 104476 - 104476
Опубликована: Март 1, 2025
Язык: Английский
Motivated reasoning and scientific racism in compulsion theory of human addiction: Methodological framework to promote social justice
Addiction Biology,
Год журнала:
2024,
Номер
29(8)
Опубликована: Авг. 1, 2024
Heinz
et
al.
(2024)
recently
criticised
habit/compulsion
theory
of
human
addiction
but
nevertheless
concluded
that
'habit
formation
plays
a
significant
role
in
drug
addiction'.
To
challenge
this
causal
claim,
the
current
article
develops
four
further
methodological
criticisms,
publications
supporting
account
addiction:
(1)
under-report
contradictory
observations;
(2)
exaggerate
process
purity
positive
(3)
under-emphasise
low
quality
epidemiological
support
for
hypothesis;
(4)
recapitulate
social
injustice
racial
intelligence
era
by
prematurely
attributing
lower
task
performance
to
user
group
membership
(endophenotype)
without
having
adequately
tested
social,
psychological,
economic
and
environmental
inequalities.
Methodological
guidelines
are
recommended
address
each
concern,
which
should
raise
evidence
standards,
incorporate
justice
improve
accuracy
estimating
any
specific
effect
history
on
performance.
Given
construing
users
as
intellectually
impaired
could
promote
stigma
reduce
their
recovery
potential,
it
is
scientific
discourse
about
habit/compulsive
endophenotypes
underpinning
avoided
until
these
higher
standards
met.
Язык: Английский