Mendelian randomization analyses uncover causal relationships between brain structural connectome and risk of psychiatric disorders
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Abstract
Growing
evidence
suggests
abnormalities
of
brain
structural
connectome
in
psychiatric
disorders,
but
the
causal
relationships
remain
underexplored.
We
conducted
bidirectional
two-sample
Mendelian
randomization
(MR)
analyses
to
investigate
links
between
206
white-matter
connectivity
phenotypes
(n
=
26,333,
UK
Biobank)
and
13
major
disorders
14,307
1,222,882).
Forward
MR
identified
effects
genetically
predicted
five
on
six
with
associations
being
significant
or
suggestive.
For
instance,
left-hemisphere
frontoparietal
control
network
right-hemisphere
default
mode
was
significantly
negatively
associated
autism
spectrum
disorder
risk,
while
increased
hippocampus
linked
decreased
anorexia
nervosa
cannabis
use
risk.
Reverse
revealed
suggestively
risk
two
four
different
phenotypes.
example,
susceptibility
found
be
visual
pallidum.
These
findings
offer
new
insights
into
etiology
highlight
potential
biomarkers
for
early
detection
prevention
at
level.
Язык: Английский
Cannabis, Weight, and Weight-Related Behaviors
Current Obesity Reports,
Год журнала:
2025,
Номер
14(1)
Опубликована: Май 8, 2025
Abstract
Purpose
of
Review
recent
research
regarding
the
relationship
between
cannabis
use,
weight,
eating
behaviors,
disorders,
and
physical
activity.
Recent
Findings
Cannabis,
particularly
cannabinoid
Δ9-tegrahydrocannabinol
(THC),
is
associated
with
increased
appetite,
food
cravings,
overconsumption,
decreased
Cannabidiol
(CBD)
appears
to
be
appetite.
While
use
not
correlated
binge
eating,
disorder
loss
control
eating.
Despite
cannabis’
association
unhealthy
sedentary
behavior,
most
studies
suggest
that
weight
gain,
or
may
even
facilitate
loss.
Summary
The
state
literature
cannabis,
weight-related
behaviors
complex.
Most
do
differentiate
profiles,
routes
administration,
whether
problematic.
Patients
presenting
for
management
should
cautioned
about
THC,
potentially
increasing
risk
activity
patterns.
Язык: Английский