Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 185 - 197
Опубликована: Янв. 1, 2023
Язык: Английский
Autoimmunity Reviews, Год журнала: 2022, Номер 22(3), С. 103259 - 103259
Опубликована: Дек. 20, 2022
Язык: Английский
Процитировано
10
Journal of Reproductive Immunology, Год журнала: 2023, Номер 158, С. 103973 - 103973
Опубликована: Май 30, 2023
Язык: Английский
Процитировано
6
Vaccines, Год журнала: 2021, Номер 9(11), С. 1351 - 1351
Опубликована: Ноя. 18, 2021
Vaccines have been developed under accelerated timelines to combat the COVID-19 pandemic caused by SARS-CoV-2 coronavirus. Although they are considered best approach for preventing mortality, when assessing safety of these vaccines, pregnant women not included in clinical trials. Thus, vaccine this demographic, as well developing fetus and neonate, remains be determined. A global effort has underway encourage get vaccinated despite uncertain risk posed them their offspring. Given this, post-hoc data collection, potentially years, will required determine outcomes vaccination on next generation. Most reactions include injection site erythema, pain, swelling, fatigue, headache, fever lymphadenopathy, which may sufficient affect fetal/neonatal development. In review, we explored components first-generation viral vector mRNA vaccines that believed contribute adverse negatively impact fetal neonatal We followed with a discussion potential using an ovine model explore long-term during prenatal periods.
Язык: Английский
Процитировано
13
Vaccines, Год журнала: 2024, Номер 12(11), С. 1281 - 1281
Опубликована: Ноя. 14, 2024
The action of mRNA-based vaccines requires the expression antigen in cells targeted by lipid nanoparticle-mRNA complexes. When vaccine is not fully retained producer cells, its local and systemic diffusion can have consequences depending on both levels biological activity. A peculiarity COVID-19 extraordinarily high amounts Spike expressed target cells. In addition, be shed bind to ACE-2 cell receptors, thereby inducing responses pathogenetic significance including release soluble factors which, turn, dysregulate key immunologic processes. Moreover, circulatory immune triggered quite powerful, lead effective anti-Spike antibody cross-binding, as well emergence auto- anti-idiotype antibodies. this paper, downsides strong efficiency translation mRNA associated with are discussed together arguments supporting idea that most them avoided advent next-generation, mucosal vaccines.
Язык: Английский
Процитировано
1
Molecular Immunology, Год журнала: 2023, Номер 157, С. 91 - 100
Опубликована: Март 30, 2023
Язык: Английский
Процитировано
3
Опубликована: Янв. 1, 2022
Coronavirus disease 2019 (COVID-19), caused by the continuously evolving novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been a global health concern since start of pandemic. Apart from other COVID-19 associated complications, emerging studies have suggested autoimmune manifestations following SARS-CoV-2. Additionally, autoantibodies detected in patients. can lead to manifestations, through various mechanisms such as molecular mimicry, bystander activation, cytokine storm, generation autoantibodies, and genetic susceptibility. Several diseases like Guillain-Barre syndrome, immune thrombocytopenic purpura, hemolytic anemia, thyroid diseases, Kawasaki disease, Alopecia areata linked with COVID-19. increased risk severe illness mortality after SARS-CoV-2 infection. Therefore, understanding pathophysiology autoimmunity aid management treatment
Язык: Английский
Процитировано
3
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 247 - 257
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Influenza and Other Respiratory Viruses, Год журнала: 2024, Номер 18(6)
Опубликована: Июнь 1, 2024
ABSTRACT Background There is debate about the causes of recent birth rate decline in high‐income countries worldwide. During pandemic, concern effects on reproductive health has caused vaccine hesitancy. We investigated association SARS‐CoV‐2 vaccination and infection with involuntary childlessness. Methods Females fertility age within a prospective multicenter cohort healthcare workers (HCW) were followed since August 2020. Data baseline health, SARS‐CoV‐2‐infection, obtained regularly updated, which serum samples collected repetitively screened for anti‐nucleocapsid anti‐spike antibodies. In October 2023, participants indicated presence childlessness onset during whereas those indicating an before pandemic excluded. The SARS‐CoV‐2‐vaccination was using univariable multivariable analysis. Sensitivity analysis performed to compare reporting birthing child Results Of 798 participants, 26 (3.2%) reported starting pandemic. childless women, 73.1% (19/26) vaccinated compared 86.0% (664/772) without ( p = 0.73). by 76.9% (20/26) 72.4% (559/772) controls 0.64). Neither (aOR 0.91 per dose, 95%CI 0.67–1.26) nor 1.05, 0.62–1.71) associated confirmed these results. Conclusions Among female HCW age, 3.2% childlessness, comparable pre‐pandemic data. No between or found.
Язык: Английский
Процитировано
0
Pathogens, Год журнала: 2023, Номер 12(2), С. 167 - 167
Опубликована: Янв. 20, 2023
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first reported in December 2019, has infected numerous subjects worldwide [...].
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 339 - 350
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
1