An Update on COVID-19-Associated Placental Pathologies
Zeitschrift für Geburtshilfe und Neonatologie,
Год журнала:
2024,
Номер
228(01), С. 42 - 48
Опубликована: Фев. 1, 2024
Abstract
COVID-19
pregnancies
are
associated
with
increased
rates
of
premature
delivery
and
stillbirths.
It
is
still
a
matter
debate
whether
there
COVID-19-associated
pattern
placenta
pathology.
We
updated
our
previously
published
results
on
systematic
literature
review
meta-analysis
pregnancies.
In
total,
38
reports
3677
placentas
were
evaluated
regarding
histopathological
changes.
Maternal
vascular
malperfusion
(32%),
fetal
(19%),
acute
chronic
inflammation
(20%
22%)
frequent
pathologies.
non-COVID-19
pregnancies,
show
similar
histologic
patterns
mainly
frequencies
manifestation.
has
to
be
taken
into
account
that
might
an
observation
bias,
because
some
findings
diagnosed
as
“pathology”
have
been
classified
minor
or
unspecific
in
placentas.
placentitis
occurs
1–2%
cases
at
the
most.
conclusion,
this
indicates
infection
during
pregnancy
does
not
result
rate
specific
pathology
rare.
Язык: Английский
Comparison of Maternal and Neonatal Outcomes between SARS-CoV-2 Variants: A Retrospective, Monocentric Study
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(19), С. 6329 - 6329
Опубликована: Окт. 1, 2023
The
impact
of
SARS-CoV-2
variants
on
maternal
and
neonatal
outcomes
during
pregnancy
is
still
poorly
understood,
the
emergence
different
has
further
complicated
our
understanding
virus’s
effects.
This
retrospective,
monocentric
study
aimed
to
fill
this
knowledge
gap
by
analyzing
pregnant
women
with
acute
infection
caused
Alpha,
Delta,
Omicron
variants.
study,
conducted
between
December
2020
March
2022
at
San
Marco
Hospital,
included
313
confirmed
infection.
results
showed
that
Delta
variant
was
associated
a
significantly
higher
incidence
adverse
outcomes,
such
as
premature
births,
intensive
care
unit
admission,
intrauterine
growth
restriction,
small
for
gestational
age
infants.
Additionally,
linked
lower
Apgar
scores,
fetal
mortality
rates,
increased
levels
various
biomarkers
indicating
more
severe
illness.
Finally,
also
presented
greater
possibility
vertical
transmission.
These
findings
underscore
complexity
especially
considering
distinctive
characteristics
By
better
specific
impacts
each
variant,
appropriate
preventive
measures
management
strategies
can
be
implemented
optimize
outcomes.
Язык: Английский
Pregnant individuals with uncomplicated pregnancies display pro‐inflammatory immune changes when exposed to the COVID‐19 pandemic
American Journal of Reproductive Immunology,
Год журнала:
2024,
Номер
91(2)
Опубликована: Фев. 1, 2024
Abstract
Problem
The
COVID‐19
pandemic
has
been
shown
to
have
a
detrimental
impact
on
the
mental
health
of
pregnant
individuals,
and
chronic
stress
can
alter
immune
profile.
However,
effects
system
in
pregnancy
are
still
poorly
understood.
We
aimed
evaluate
exposure
maternal
profile
uncomplicated
pregnancies.
Method
study
collected
blood
placenta
samples
from
individuals
exposed
unexposed
compare
their
inflammatory
profiles.
performed
co‐culture
with
circulating
cells
endothelial
assess
activation.
Statistical
analysis
was
using
unpaired
t‐test,
Mann‐Whitney,
or
Fisher's
exact
test
as
appropriate.
Results
In
we
observed
decreased
proportion
Th2
(
p
<
.0001)
Treg/Th17
ratio
.05),
well
an
increased
Th1/Th2
.0001).
Levels
IL‐1β
.01)
IL‐18
were
circulation
participants,
whilst
other
mediators
significantly
(IFNγ,
IL‐8,
MCP‐1,
amongst
others).
Furthermore,
production
ICAM,
hallmark
activation,
when
co‐cultured
individuals.
Vaccination
status
impacted
cellular
proportions
Th1
B
vaccinated
participants.
Conclusion
Overall,
pro‐inflammatory
bias
pandemic,
otherwise
Our
work
also
supports
association
between
risk
activation/hypertension
SARS‐CoV2
infection,
which
might
be
driven
part
by
associated
stressors.
Язык: Английский