A pathogenic integrated view explaining the different endotypes of asthma and allergic disorders DOI
Enrico Maggi, Paola Parronchi, Bruno Azzarone

и другие.

Allergy, Год журнала: 2022, Номер 77(11), С. 3267 - 3292

Опубликована: Июль 17, 2022

The inflammation of allergic diseases is characterized by a complex interaction between type 2 and 3 immune responses, explaining clinical symptoms histopathological patterns. Airborne stimuli activate the mucosal epithelium to release number molecules impacting activity resident environmental cells. Signals from barrier, regulatory cells, inflamed tissue are crucial conditions able modify innate adaptive effector cells providing selective homing eosinophils or neutrophils. high plasticity T- lymphoid responding external signals prerequisite explain multiplicity endotypes diseases. This notion paved way for huge use specific biologic drugs interfering with pathogenic mechanisms inflammation. Based on response epithelial functions structural non-lymphoid this review proposes some immunopathogenic scenarios characterizing principal which can be associated precise phenotype asthma. Recent literature indicates that similar concepts also applied other non-respiratory disorders. next challenges will consist in defining biomarker(s) each endotype allowing quick diagnosis most effective personalized therapy.

Язык: Английский

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023 DOI Creative Commons

Sarah K. Wise,

Cecelia Damask,

Lauren T. Roland

и другие.

International Forum of Allergy & Rhinology, Год журнала: 2023, Номер 13(4), С. 293 - 859

Опубликована: Март 6, 2023

In the 5 years that have passed since publication of 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic 2018), literature has expanded substantially. The ICAR-Allergic 2023 update presents 144 individual topics allergic rhinitis (AR), by over 40 from document. Originally presented also been reviewed updated. executive summary highlights key evidence-based findings recommendation full

Язык: Английский

Процитировано

231
CD39/CD73/A2AR pathway and cancer immunotherapy DOI Creative Commons

Chenglai Xia,

Shuanghong Yin,

Kenneth K.W. To

и другие.

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Март 2, 2023

Abstract Cancer development is closely associated with immunosuppressive tumor microenvironment (TME) that attenuates antitumor immune responses and promotes cell immunologic escape. The sequential conversion of extracellular ATP into adenosine by two important cell-surface ectonucleosidases CD39 CD73 play critical roles in reshaping an TME. accumulated mediates its regulatory functions binding to one four receptors (A1R, A2AR, A2BR A3R). A2AR elicits profound function via regulating cAMP signaling. increasing evidence suggests CD39, could be used as novel therapeutic targets for manipulating the immunity. In recent years, monoclonal antibodies or small molecule inhibitors targeting CD39/CD73/A2AR pathway have been investigated clinical trials single agents combination anti-PD-1/PD-L1 therapies. this review, we provide updated summary about pathophysiological adenosinergic cancer development, metastasis drug resistance. more components therapy circumvention immunotherapy resistance are also discussed. Emerging biomarkers may guide selection CD39/CD73/A2AR-targeting treatment strategies individual patients deliberated.

Язык: Английский

Процитировано

148
Roles and mechanisms of tumour-infiltrating B cells in human cancer: a new force in immunotherapy DOI Creative Commons

Enkui Zhang,

Chengsheng Ding,

Shuchun Li

и другие.

Biomarker Research, Год журнала: 2023, Номер 11(1)

Опубликована: Март 9, 2023

Abstract Immune checkpoint inhibitors (ICIs) targeting PD-1 or PD-L1 have emerged as a revolutionary treatment strategy for human cancer patients. However, the response rate to ICI therapy varies widely among different types of tumours, we are beginning gain insight into mechanisms well biomarkers therapeutic and resistance. Numerous studies highlighted dominant role cytotoxic T cells in determining ICIs. Empowered by recent technical advances, such single-cell sequencing, tumour-infiltrating B been identified key regulator several solid tumours affecting tumour progression In current review, summarized advances regarding underlying therapy. Some shown that B-cell abundance is positively associated with favourable clinical outcomes, while others indicated they tumour-promoting, implying biological function complex landscape. The molecular involved multiple aspects functions cells, including activation CD8+ secretion antibodies cytokines, facilitation antigen presentation process. addition, other crucial mechanisms, regulatory (Bregs) plasma discussed. Here, summarizing dilemmas studies, depicted landscape cancers paved way future research this field. Graphical

Язык: Английский

Процитировано

58
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome DOI

Arshia Shahini,

Ali Shahini

Journal of Cell Communication and Signaling, Год журнала: 2022, Номер 17(1), С. 55 - 74

Опубликована: Сен. 16, 2022

Язык: Английский

Процитировано

69
Toll-like receptor 9 agonists and combination therapies: strategies to modulate the tumour immune microenvironment for systemic anti-tumour immunity DOI Open Access
Zhangchi Dongye, Jian Li, Yuzhang Wu

и другие.

British Journal of Cancer, Год журнала: 2022, Номер 127(9), С. 1584 - 1594

Опубликована: Июль 28, 2022

Язык: Английский

Процитировано

63
The emerging role of regulatory cell-based therapy in autoimmune disease DOI Creative Commons
Farbod Ghobadinezhad,

Nasim Ebrahimi,

Fatemeh Mozaffari

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Дек. 14, 2022

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects millions of people each year and poses a great social economic burden individuals communities. In the course autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes mellitus, multiple sclerosis, disturbances in balance between response against harmful agents tolerance towards self-antigens lead an self-tissues. recent years, various regulatory cells have been identified. Disruptions quality, quantity, function these implicated disease development. Therefore, targeting or engineering is promising therapeutic for different diseases. Regulatory T cells, B dendritic myeloid suppressor some subsets innate lymphoid are arising as important players among this class cells. Here, we review roles suppressive cell system during homeostasis development autoimmunity. Moreover, discuss current future potential one types

Язык: Английский

Процитировано

59
Human IL-10-producing B cells have diverse states that are induced from multiple B cell subsets DOI Creative Commons
Marla C. Glass, David R. Glass,

John-Paul Oliveria

и другие.

Cell Reports, Год журнала: 2022, Номер 39(3), С. 110728 - 110728

Опубликована: Апрель 1, 2022

Regulatory B cells (Bregs) suppress immune responses through the secretion of interleukin-10 (IL-10). This immunomodulatory capacity holds therapeutic potential, yet a definitional immunophenotype for enumeration and prospective isolation capable IL-10 production remains elusive. Here, we simultaneously quantify cytokine in human peripheral across range stimulatory conditions time points using mass cytometry. Our analysis shows that multiple functional cell subsets produce no phenotype uniquely identifies IL-10+ cells. Further, significant portion co-express pro-inflammatory cytokines IL-6 tumor necrosis factor alpha (TNFα). Despite this heterogeneity, operationally tolerant liver transplant recipients have unique enrichment IL-10+, but not TNFα+ or IL-6+, compared with receiving immunosuppression. Thus, IL-10-producing constitute an induced, transient state arising from diversity may contribute to maintenance homeostasis.

Язык: Английский

Процитировано

54
Regulatory B Cells—Immunopathological and Prognostic Potential in Humans DOI Creative Commons

Johanna Veh,

Carolin Ludwig, Hubert Schrezenmeier

и другие.

Cells, Год журнала: 2024, Номер 13(4), С. 357 - 357

Опубликована: Фев. 18, 2024

The aim of the following review is to shed light on putative role regulatory B cells (Bregs) in various human diseases and highlight their potential prognostic therapeutic relevance humans. Regulatory are a heterogeneous group lymphocytes capable suppressing inflammatory immune reactions. In this way, Bregs contribute maintenance tolerance homeostasis by limiting ongoing reactions temporally spatially. play an important attenuating pathological that can be associated with transplant rejection, graft-versus-host disease, autoimmune allergies but also infectious, neoplastic metabolic diseases. Early studies identified IL-10 as functional molecule, so IL-10-secreting murine B10 cell still considered prototype Breg, has long been central search for Breg equivalents. However, over past two decades, other molecules may immunosuppressive function have discovered, some which only present Bregs. This expanded arsenal includes several anti-inflammatory cytokines, such IL-35 TGF-β, enzymes CD39/CD73, granzyme IDO well surface proteins including PD-L1, CD1d CD25. summary, illustrates concise comprehensive manner although share common features leading prominent immunpathologies, they composed pool different types rather phenotypic transcriptional properties.

Язык: Английский

Процитировано

16
Breg-Mediated Immunoregulation in the Skin DOI Open Access
Elina A. Zheremyan, Alina S. Ustiugova,

Nina M. Karamushka

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(1), С. 583 - 583

Опубликована: Янв. 2, 2024

Wound healing is a complex process involving coordinated series of events aimed at restoring tissue integrity and function. Regulatory B cells (Bregs) are subset lymphocytes that play an essential role in fine-tuning immune responses maintaining homeostasis. Recent studies have suggested Bregs important players cutaneous immunity. This review summarizes the current understanding skin immunity health pathology, such as diabetes, psoriasis, systemic sclerosis, lupus erythematosus, hypersensitivity, pemphigus, dermatomyositis. We discuss mechanisms by which maintain homeostasis wound microenvironment through promotion angiogenesis, suppression effector cells, induction regulatory cells. also mention potential clinical applications promoting healing, use adoptive Breg transfer.

Язык: Английский

Процитировано

10
Immune signatures predict response to house dust mite subcutaneous immunotherapy in patients with allergic rhinitis DOI
Nan Wang, Jia Song,

Shi‐Ran Sun

и другие.

Allergy, Год журнала: 2024, Номер 79(5), С. 1230 - 1241

Опубликована: Фев. 25, 2024

Identifying predictive biomarkers for allergen immunotherapy response is crucial enhancing clinical efficacy. This study aims to identify such in patients with allergic rhinitis (AR) undergoing subcutaneous (SCIT) house dust mite allergy.

Язык: Английский

Процитировано

9