Pediatric Pulmonology,
Год журнала:
2021,
Номер
57(1), С. 66 - 74
Опубликована: Окт. 4, 2021
Abstract
Background
Lockdown
measures
during
the
SARS‐CoV‐2
pandemic
determined
radical
changes
to
behavioral
and
social
habits,
that
were
reflected
by
a
reduction
in
transmission
of
respiratory
pathogens
anthropogenic
atmospheric
emissions.
Objective
This
ecological
study
aims
provide
descriptive
evaluation
on
how
restrictive
impacted
Pediatric
Emergency
Department
(PED)
referrals
for
asthma
exacerbations,
their
potentially
associated
environmental
triggers
Bologna,
densely
populated
urban
area
Northern
Italy.
Methods
Files
children
evaluated
acute
2015
2020
at
PED
Sant'Orsola
University
Hospital
Bologna
retrospectively
reviewed.
Historical
daily
concentration
records
particulate
(PM
2.5
,
PM
10
)
gaseous
(NO
2
C
6
H
air
pollutants,
pollen
concurrently
evaluated,
including
specific
chemical
tracers
traffic‐related
pollution
(TRAP).
Results
In
2020,
asthma‐related
decreased
compared
referral
rates
previous
5
years
(
p
<
0.01).
effect
was
particularly
marked
first
lockdown
period
(March
May),
when
drastic
drop
with
high‐priority
cases
up
85%
54%,
average.
A
concomitant
concentrations
pollutants
observed
range
40%–60%
Conclusions
The
lower
rate
exacerbations
childhood
this
paralleled
reduced
TRAP
levels
pandemic.
Synergic
interactions
multiple
consequences
lockdowns
likely
contributed
exposure
ambient
fewer
infections,
identified
as
most
important
factor
literature.
Journal of Asthma,
Год журнала:
2023,
Номер
60(8), С. 1601 - 1607
Опубликована: Янв. 6, 2023
A
better
understanding
of
the
impacts
Coronavirus
disease
2019
(COVID-19)
pandemic
on
emergency
department
(ED)
visits
for
asthma
is
needed
to
improve
control.
Frontiers in Pediatrics,
Год журнала:
2021,
Номер
9
Опубликована: Апрель 29, 2021
Coronavirus
disease
2019
(COVID-19)
is
a
pandemic
infectious
caused
by
severe
acute
respiratory
syndrome
coronavirus
SARS-COV-2.
Aberrant
innate
immunity
response
and
cytokine
storm
are
responsible
for
the
syndrome.
Apparently,
in
asthmatic
patients,
inadequate
antiviral
immune
tendency
asthma
exacerbation
evoked
common
viruses
could
explain
increased
susceptibility
to
SARS-COV-2
infection.
However,
has
not
been
suggested
be
risk
factor
COVID-19
patients.
Therefore,
patients
some
potential
protective
mechanisms
against
have
hypothesized,
like
type
2
response,
number
of
eosinophils,
overproduction
mucus,
treatment,
along
with
behavioral
factors
strictly
related
asthma,
such
as
social
distancing,
hygiene
measures
wearing
facemasks,
that
contribute
reduce
individual
In
this
mini-review,
we
will
describe
current
literature
regarding
children
based
on
evidence
available
so
far.
Pediatric Allergy and Immunology,
Год журнала:
2023,
Номер
34(11)
Опубликована: Ноя. 1, 2023
Wheezing
is
common
among
preschool
children,
representing
a
group
of
highly
heterogeneous
conditions
with
varying
natural
history.
Several
phenotypes
wheezing
have
been
proposed
to
facilitate
the
identification
young
children
who
are
at
risk
subsequent
development
asthma.
Epidemiological
and
immunological
studies
across
different
populations
revealed
key
role
environmental
factors
in
influencing
progression
from
childhood
Significant
include
severe
respiratory
infections,
allergic
sensitization,
exposure
tobacco
smoke.
In
contrast,
farming/rural
environment
has
linked
asthma
protection
both
human
animal
studies.
Early
intense
exposures
microorganisms
microbial
metabolites
demonstrated
alter
host
immune
responses
allergens
viruses,
thereby
driving
trajectory
away
illness
Ongoing
clinical
trials
candidate
microbes
products
shown
promise
shaping
function
reduce
episodes
viral-induced
wheezing.
Moreover,
restoring
training
may
be
especially
important
for
had
reduced
due
pandemic
restrictions.
A
comprehensive
understanding
modifiable
will
pave
way
developing
targeted
prevention
strategies
Pediatric Pulmonology,
Год журнала:
2022,
Номер
57(7), С. 1668 - 1676
Опубликована: Май 3, 2022
It
is
not
clear
whether
asthma,
the
most
frequent
chronic
disease
in
childhood,
a
risk
for
severe
SARS-CoV-2
infection
pediatric
population
and
how
affects
lung
functions
these
patients.
Life,
Год журнала:
2021,
Номер
11(6), С. 561 - 561
Опубликована: Июнь 14, 2021
While
molecular
testing
with
real-time
polymerase
chain
reaction
(RT-PCR)
remains
the
gold-standard
test
for
COVID-19
diagnosis
and
screening,
more
rapid
or
affordable
antigen
options
have
been
developed.
More
affordable,
point-of-care
testing,
despite
being
less
sensitive
compared
to
assays,
might
be
preferable
wider
screening
initiatives.
Simple
laboratory,
imaging
clinical
parameters
could
facilitate
prognostication
triage.
This
comprehensive
review
summarises
current
evidence
on
diagnostic,
prognostic
tests
COVID-19.
Pediatric Allergy and Immunology,
Год журнала:
2022,
Номер
33(10)
Опубликована: Сен. 30, 2022
Abstract
By
the
April
12,
2022,
COVID‐19
pandemic
had
resulted
in
over
half
a
billion
people
being
infected
worldwide.
There
have
been
6.1
million
deaths
directly
due
to
infection,
but
has
many
more
short‐
and
long‐term
pervasive
effects
on
physical
mental
health
of
population.
Allergic
diseases
are
among
most
prevalent
noncommunicable
chronic
pediatric
population,
health‐care
professionals
researchers
were
seeking
answers
since
beginning
pandemic.
Children
at
lower
risk
developing
severe
or
dying
from
infection.
not
associated
with
higher
severity
mortality,
apart
severe/poorly
controlled
asthma.
The
disrupted
routine
care,
mitigation
strategies,
including
limited
telemedicine,
successfully
implemented
continue
delivery
high‐standard
care.
Although
children
faced
multitude
pandemic‐related
issues,
allergic
conditions
effectively
treated
remotely
while
reduction
air
pollution
lack
contact
outdoor
allergens
improvement,
particularly
respiratory
allergies.
is
no
evidence
recommend
substantial
changes
usual
management
modalities
children,
allergen
immunotherapy
use
biologicals.
greater
multisystem
inflammatory
syndrome
development,
some
associations
Long
COVID
reported,
although
data
limited,
further
research
needed.
This
statement
EAACI
Section
Pediatrics
provides
recommendations
based
lessons
learnt
pandemic,
as
available
evidence.