Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019

Allergy, Год журнала: 2023, Номер 78(8), С. 2232 - 2254

Опубликована: Июль 11, 2023

Abstract Background Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with rhinitis food allergy cause high morbidity mortality both in children adults. This study aims to evaluate the global, regional, national, temporal trends of burden asthma AD from 1990 2019 analyze their associations geographic, demographic, social, clinical factors. Methods Using data Global Burden Diseases (GBD), Injuries, Risk Factors Study 2019, we assessed age‐standardized prevalence, incidence, mortality, disability‐adjusted life years (DALYs) stratified by geographic region, age, sex, socio‐demographic index (SDI). DALYs were calculated as sum lived disability lost premature mortality. Additionally, disease attributable body mass index, occupational asthmagens, smoking was described. Results In there a total 262 million [95% uncertainty interval (UI): 224–309 million] cases 171 UI: 165–178 globally; prevalence rates 3416 2899–4066] 2277 2192–2369] per 100,000 population for AD, respectively, 24.1% −27.2 −20.8] decrease 4.3% 3.8–4.8] compared baseline 1990. Both had similar according age‐specific peaking at age 5–9 rising again adulthood. The incidence higher individuals SDI; however, reverse trend, those lower SDI quintiles. Of three risk factors, contributed highest deaths due asthma, accounting 3.65 2.14–5.60 75,377 40,615–122,841] deaths. Conclusions continue significant worldwide, having increased but decreased 2019. Although more frequent younger ages prevalent high‐SDI countries, each condition has distinct regional characteristics. Understanding temporospatial could guide future policies interventions better manage these diseases worldwide achieve equity prevention, diagnosis, treatment.

Язык: Английский

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Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Апрель 2, 2024

Abstract As mounting evidence suggests a higher incidence of adverse consequences, such as disruption the immune system, among patients with history COVID-19, we aimed to investigate post-COVID-19 conditions on comprehensive set allergic diseases including asthma, rhinitis, atopic dermatitis, and food allergy. We used nationwide claims-based cohorts in South Korea (K-CoV-N; n = 836,164; main cohort) Japan (JMDC; 2,541,021; replication cohort A) UK Biobank (UKB; 325,843; B) after 1:5 propensity score matching. Among 836,164 individuals (mean age, 50.25 years [SD, 13.86]; 372,914 [44.6%] women), 147,824 were infected SARS-CoV-2 during follow-up period (2020−2021). The risk developing diseases, beyond first 30 days diagnosis significantly increased (HR, 1.20; 95% CI, 1.13−1.27), notably asthma 2.25; 1.80−2.83) rhinitis 1.23; 1.15−1.32). This gradually decreased over time, but it persisted throughout (≥6 months). In addition, increasing severity COVID-19. Notably, COVID-19 vaccination at least two doses had protective effect against subsequent 0.81; 0.68−0.96). Similar findings reported A B. Although potential for misclassification pre-existing incident remains limitation, ethnic diversity condition has been validated by utilizing multinational independent population-based cohorts.

Язык: Английский

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Machine Learning–Based Prediction of Suicidality in Adolescents With Allergic Rhinitis: Derivation and Validation in 2 Independent Nationwide Cohorts

Journal of Medical Internet Research, Год журнала: 2024, Номер 26, С. e51473 - e51473

Опубликована: Фев. 14, 2024

Background Given the additional risk of suicide-related behaviors in adolescents with allergic rhinitis (AR), it is important to use growing field machine learning (ML) evaluate this risk. Objective This study aims validity and usefulness an ML model for predicting suicide patients AR. Methods We used data from 2 independent survey studies, Korea Youth Risk Behavior Web-based Survey (KYRBS; n=299,468) original set National Health Nutrition Examination (KNHANES; n=833) external validation set, predict risks AR aged 13 18 years, 3.45% (10,341/299,468) 1.4% (12/833) attempting KYRBS KNHANES respectively. The outcome interest was attempt risks. selected various ML-based models hyperparameter tuning discovery performed area under receiver operating characteristic curve (AUROC) analysis train, test, data. Results included 299,468 set) 833 recruited between 2005 2022. best-performing random forest a mean AUROC 84.12% (95% CI 83.98%-84.27%) set. Applying result revealed best performance among models, 89.87% (sensitivity 83.33%, specificity 82.58%, accuracy 82.59%, balanced 82.96%). While looking at feature importance, 5 most features attempts adolescent are depression, stress status, academic achievement, age, alcohol consumption. Conclusions emphasizes potential AR, encouraging further application these other conditions enhance health decrease rates.

Язык: Английский

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Global, regional and national epidemiology of allergic disorders in children from 1990 to 2019: findings from the Global Burden of Disease study 2019

BMJ Open, Год журнала: 2024, Номер 14(4), С. e080612 - e080612

Опубликована: Апрель 1, 2024

Objective This modelling study aimed to estimate the burden for allergic diseases in children during a period of 30 years. Design Population-based observational study. Main outcomes and measures The data on incidence, mortality disability-adjusted life years (DALYs) childhood diseases, such as atopic dermatitis (AD) asthma, were retrieved from Global Burden Disease 2019 online database. set spans various groups, including different regions, ages, genders Socio-Demographic Indices (SDI), covering 1990 2019. Results In 2019, there approximately 81 million with asthma 5.6 AD worldwide. global incidence was 20 million. Age-standardised rates showed decrease 4.17% 1075.14 (95% uncertainty intervals (UI), 724.63 1504.93) per 100 000 population 1030.33 UI, 683.66 1449.53) Similarly, decreased by 5.46%, 594.05 547.98 642.88) 561.61 519.03 608.29) both highest under 5 age, gradually decreasing age. Interestingly, an increase SDI associated rise conditions. However, rate DALYs contrasting trend. Conclusions Over past three decades, has been worldwide new cases, even though have significantly declined. prevalence these among varies considerably across countries age groups. variation highlights need precise assessments. These assessments are vital formulating effective strategies prevention treatment.

Язык: Английский

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National prevalence and trends in food labeling awareness, comprehension, usage, and COVID-19 pandemic-related factors in South Korea, 2014–2022

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 31, 2024

Although food labeling on packages is crucial for promoting a healthy diet, limited research has been conducted how the COVID-19 pandemic (hereinafter "the pandemic") affected awareness. Therefore, this study aims to analyze changes in trends awareness, comprehension, and usage South Korea during pandemic. We utilized nationwide, large-scale, long-term dataset provided by Community Health Survey (KCHS) from 2014 2022 (total = 1,756,847 participants). This allowed researchers assess prevalence of usage. Furthermore, we investigated factors associated with awareness specifically related In total, adults (54.19% women) participated study. The upward slope overall became less pronounced even exhibited downward (βdiff - 1.759; 95% CI 1.874 1.644). comprehension more (comprehension: βdiff 0.535; 0.436-0.634; usage: 0.693; 0.601-0.785). vulnerability lower included older age, male, obesity, residing rural areas, household income, educational level, smoking, increased alcohol consumption. analyzed 9-year trend based nationally representative data 2022. Our findings suggest that personalized nutrition strategies are needed recognize vulnerable groups risk improve among Korean

Язык: Английский

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A real-world pharmacovigilance study of omalizumab using disproportionality analysis in the FDA adverse drug events reporting system database

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 7, 2025

Omalizumab is a biologic agent used in the management of allergic conditions, including asthma and urticaria. Although efficacy omalizumab has been well established, its safety profile primarily derived from clinical trials with limited sample sizes. To conduct comprehensive evaluation larger populations, this study conducted an extensive analysis data sourced America Food Drug Administration's Adverse Event Reporting System (FAERS), aim elucidating adverse drug events associated real-world settings. We extracted reports FAERS database covering period first quarter 2004 to second 2024. assessed significance association between using four distinct methods disproportionality analysis. Furthermore, we analyzed across gender age subgroups. identified total 49,456 event linked pinpointed 357 related within 27 system organ classes. These encompassed several commonly reported reactions documented product labeling, anaphylactic (ROR: 17.28, 95%CI:16.62–17.96) (ROR:19.24, 95%CI:18.74–19.76), alongside unlisted such as asthmatic crisis 47.3, 95%CI: 43–52.03), lower respiratory tract congestion 35.68, 30.42–41.84). results our indicated that omalizumab-related displayed significant disparities. The median time onset for all was approximately 145 days, substantial proportion occurring after one year treatment. This not only offers reference optimizing utilization omalizumab, enhancing while minimizing potential side effects, but also facilitates safe application broader implementation practice.

Язык: Английский

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National and regional trends in the prevalence of type 2 diabetes and associated risk factors among Korean adults, 2009–2021

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Окт. 4, 2023

Abstract Disproportionate impact of COVID-19 on socioeconomic and behavioral variables may have impacted the prevalence diabetes. We utilized nationwide long-term serial study from 2009 to 2021 Korea Community Health Survey (KCHS). explored national regional trends diabetes according factors before during pandemic. Also, we interpreted which groups became more vulnerable diagnosed A total 2,971,349 adults aged (19 39, 40 59, ≥ 60 years) were included in analysis. The increased slowly pandemic (11.6% [95% CI 11.5–11.7] 2020 12.4% 12.3–12.6] 2021), compared pre-pandemic era (7.9% 7.8–7.9] 2009–2011 11.3% 11.3–11.4] 2018–2019). women, low-income group, low-educational infrequent walking group showed less than others. diabetic population expected seems contribute an unanticipated increase under-diagnosis among already minority. This suggest reinforcing access healthcare services minority

Язык: Английский

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Effects of micronutrients and macronutrients on risk of allergic disease in the European population: a Mendelian randomization study

Food and Agricultural Immunology, Год журнала: 2024, Номер 35(1)

Опубликована: Дек. 19, 2024

Background: Regional lifestyles influence allergic disease risks, with dietary factors being crucial. However, observational studies on micro- and macronutrient impacts are inconsistent.

Язык: Английский

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National Trends in the Prevalence of Screen Time and Its Association With Biopsychosocial Risk Factors Among Korean Adolescents, 2008–2021

Journal of Adolescent Health, Год журнала: 2023, Номер 74(3), С. 504 - 513

Опубликована: Дек. 11, 2023

Язык: Английский

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National Trends and Prevalence of Atopic Dermatitis and Pandemic-Related Factors among Korean Adults, 2007–2021

International Archives of Allergy and Immunology, Год журнала: 2024, Номер 185(4), С. 320 - 333

Опубликована: Янв. 1, 2024

<b><i>Introduction:</i></b> Previous studies have variably reported inconclusive trends in the prevalence of atopic dermatitis (AD) among adults, and there are limited data on impact COVID-19 pandemic. We aimed to investigate national age-stratified AD adults from 2007 2021 South Korea, focusing mainly pandemic-related factors. <b><i>Methods:</i></b> A nationwide cross-sectional study was conducted using Korea National Health Nutrition Examination Survey 2021. Overall for were assessed weighted beta coefficients or odds ratios. <b><i>Results:</i></b> total 83,566 over 20 years (male, 49.40%) included. During observation period, stable overall population 2.61% (95% CI, 2.29–2.93) 2007–2009 2.15% (1.68–2.63) 2020 2.38% (1.81–2.95) However, aged 40–59 old decreased during pre-pandemic era, above 60 significantly pandemic, with a significant decline observed after initial outbreak. From age-stratification analysis, showed increase pandemic outbreak which evident specific variables: individuals rural residence, lower education, household income quartiles. Adults decrease slope outbreak, female, <b><i>Conclusion:</i></b> throughout 15-year period. analysis suggested different according groups AD.

Язык: Английский

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