The impact of high‐IgE levels on metabolome and microbiome in experimental allergic enteritis DOI Creative Commons
Elisa Zubeldia‐Varela, Frank Blanco‐Pérez, Tomás Clive Barker‐Tejeda

и другие.

Allergy, Год журнала: 2024, Номер unknown

Опубликована: Июнь 23, 2024

Abstract Background The pathological mechanism of the gastrointestinal forms food allergies is less understood in comparison to other clinical phenotypes, such as asthma and anaphylaxis Importantly, high‐IgE levels are a poor prognostic factor allergies. Methods This study investigated how influence development intestinal inflammation metabolome allergic enteritis (AE), using IgE knock‐in (IgEki) mice expressing high IgE. In addition, correlation altered with gut microbiome was analysed. Results Ovalbumin‐sensitized egg‐white diet‐fed (OVA/EW) BALB/c WT developed moderate AE, whereas OVA/EW IgEki induced more aggravated enhanced eosinophil accumulation. Untargeted metabolomics detected increased N‐tau‐methylhistamine 2,3‐butanediol, reduced butyric acid faeces and/or sera mice, which accompanied Clostridium Lactobacillus at genus level. Non‐sensitized (NC/EW) did not exhibit any signs NC/EW marginal degrees AE. Compared lysophospholipids, sphinganine sphingosine were serum faecal samples mice. several associations microbiome—for example Akkermansia lysophosphatidylserine—were detected. Conclusions Our results suggest that alter systemic endogenous microbiota‐associated metabolites experimental contributes deepening knowledge molecular mechanisms for AE provides clues advance diagnostic therapeutic strategies diseases.

Язык: Английский

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology DOI Creative Commons
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla

и другие.

Allergy, Год журнала: 2023, Номер 79(5), С. 1089 - 1122

Опубликована: Дек. 18, 2023

Abstract The accumulation of senescent cells drives inflammaging and increases morbidity chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy substrates for proliferation, differentiation, activation. Metabolic imposed by environmental stress inflammation on immune tissue microenvironment thus chiefly involved the pathophysiology allergic other immune‐driven Altered is also a hallmark senescence, condition characterized loss proliferative activity remain metabolically active. Accelerated senescence can be triggered acute or responses. In contrast, replicative occurs as part physiological aging process has protective roles cancer surveillance wound healing. Importantly, change hamper response to diverse therapeutic treatments. Understanding metabolic pathways structural therefore critical detect, prevent, revert detrimental aspects senescence‐related immunopathology, developing specific diagnostics targeted therapies. this paper, we review main alterations occurring (macrophages, B cells, T cells). Subsequently, present footprints described translational studies patients with asthma obstructive pulmonary disease (COPD), ongoing preclinical clinical trials approaches aiming at targeting antagonize pathological senescence. Because recently emerging field allergy immunology, better understanding profile complex landscape needed. progress achieved so far already providing opportunities new therapies, well strategies aimed prevention supporting healthy aging.

Язык: Английский

Процитировано

12
Addition of Polyphenols to Drugs: The Potential of Controlling “Inflammaging” and Fibrosis in Human Senescent Lung Fibroblasts In Vitro DOI Open Access

Maria Carolina Ximenes de Godoy,

Gabriela Arruda Monteiro,

Bárbara Hakim de Moraes

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7163 - 7163

Опубликована: Июнь 28, 2024

The combination of a polyphenol, quercetin, with dasatinib initiated clinical trials to evaluate the safety and efficacy senolytics in idiopathic pulmonary fibrosis, lung disease associated presence senescent cells. Another approach senotherapeutics consists controlling inflammation related cellular senescence or “inflammaging”, which participates, among other processes, establishing fibrosis. We whether polyphenols such as caffeic acid, chlorogenic epicatechin, gallic resveratrol combined different metformin rapamycin, antifibrotic drugs nintedanib pirfenidone, could present beneficial actions an vitro model MRC-5 fibroblasts. A senescent-associated secretory phenotype (SASP) was evaluated by measurement interleukin (IL)-6, IL-8, IL-1β. β-galactosidase (SA-β-gal) activity proliferation were assessed. Fibrosis using Picrosirius red assay gene expression fibrosis-related genes. Epithelial-mesenchymal transition (EMT) assayed A549 cell line exposed Transforming Growth Factor (TGF)-β vitro. that demonstrated best results inhibiting IL-6 IL-8 Metformin acid also restore reduce SA-β-gal during induction. collagen production cells inhibited epicatechin alone drugs. Epicatechin able control EMT In conclusion, can potentially increase effectiveness senotherapeutic diseases whose pathophysiological component is

Язык: Английский

Процитировано

4
Malnutrition and Allergies: Tipping the Immune Balance towards Health DOI Open Access
Εmilia Vassilopoulou, Carina Venter, Franziska Roth‐Walter

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(16), С. 4713 - 4713

Опубликована: Авг. 11, 2024

Malnutrition, which includes macro- and micronutrient deficiencies, is common in individuals with allergic dermatitis, food allergies, rhinitis, asthma. Prolonged deficiencies of proteins, minerals, vitamins promote Th2 inflammation, setting the stage for sensitization. Consequently, malnutrition, fosters development while an adequate supply micronutrients promotes immune cells regulatory tolerogenic phenotypes. As protein mimic infection, body’s innate response limits access to these nutrients by reducing their dietary absorption. This review highlights our current understanding physiological functions allergenic iron, vitamin A, particularly regarding reduced bioavailability under inflamed conditions, necessitating different approaches improve Additionally, role most allergens as nutrient binders involvement nutritional immunity will be briefly summarized. Their ability bind close association can trigger exaggerated responses allergies deficiencies. However, nutrient-rich also provide health.

Язык: Английский

Процитировано

4
Immp2l gene knockout induces granulosa cell senescence by activation of cGAS-STING pathway via TFAM-mediated mtDNA leakage DOI

Pengge Pan,

Sinan Cao,

Hui Gao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142368 - 142368

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Rosuvastatin restores liver tissue-resident NK cell activation in aged mice by improving mitochondrial function DOI
Johnny Amer,

Ahmad Salhab,

Rifaat Safadi

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118000 - 118000

Опубликована: Март 24, 2025

Язык: Английский

Процитировано

0
Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways DOI Creative Commons
Bowei Liu, Zhigang Peng, Hao Zhang

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 2, 2025

Cellular senescence, a stable state of cell cycle arrest induced by various stressors or genomic damage, is recognized as hallmark cancer. It exerts context-dependent dual role in cancer initiation and progression, functioning tumor suppressor promoter. The complexity senescence arises from its mechanistic diversity, potential reversibility, heterogeneity. A key mediator these effects the senescence-associated secretory phenotype (SASP), repertoire bioactive molecules that influence microenvironment (TME) remodeling, modulate behavior, contribute to therapeutic resistance. Given intricate biology, presents both challenges opportunities for intervention. Strategies targeting pathways, including senescence-inducing therapies senolytic approaches, offer promising avenues treatment. This review provides comprehensive analysis regulatory mechanisms governing cellular tumors. We also discuss emerging strategies highlighting novel opportunities. deeper understanding processes essential developing precision improving clinical outcomes.

Язык: Английский

Процитировано

0
The role of the cGAS-STING pathway in chronic pulmonary inflammatory diseases DOI Creative Commons

Mengxiang Tian,

Fengyuan Li,

Haiping Pei

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Окт. 30, 2024

The innate immune system plays a vital role in the inflammatory process, serving as crucial mechanism for body to respond infection, cellular stress, and tissue damage. cGAS-STING signaling pathway is pivotal onset progression of various autoimmune diseases chronic inflammation. By recognizing cytoplasmic DNA, this initiates regulates inflammation antiviral responses within system. Consequently, regulation has become prominent area interest treatment many diseases. Chronic lung diseases, such obstructive pulmonary disease (COPD), asthma, fibrosis, are characterized by persistent or recurrent damage, leading diminished respiratory function. This paper explores action these examines development STING inhibitors nanomaterial applications, discusses potential clinical application prospects targeting

Язык: Английский

Процитировано

2
State of the art: Alternative overlap syndrome—asthma and obstructive sleep apnea DOI
Octavian C. Ioachimescu

Journal of Investigative Medicine, Год журнала: 2024, Номер 72(7), С. 589 - 619

Опубликована: Май 8, 2024

In the general population, Bronchial Asthma (BA) and Obstructive Sleep Apnea (OSA) are among most prevalent chronic respiratory disorders. Significant epidemiologic connections complex pathogenetic pathways link these disorders via interactions at genetic, epigenetic, environmental levels. The coexistence of BA OSA in an individual likely represents a distinct syndrome, that is, collection clinical manifestations attributable to several mechanisms pathobiological signatures. To avoid terminological confusion, this association has been named alternative overlap syndrome (vs represented by obstructive pulmonary disease-OSA association). This comprehensive review summarizes complex, often bidirectional links between constituents syndrome. Cross-sectional, or clinic-based studies unlikely elucidate causality directionality relationships. Even longitudinal epidemiological evaluations cohorts developing over time OSA, during follow-up cannot exclude factors causal influence other known unknown mediators. As such, lot pathophysiological described here have suggestive evidence, biological plausibility, potential actual directionality. By showcasing existing evidence current knowledge gaps, hope is deliberate, focused, collaborative efforts near-future will be geared toward opportunities shine light on unknowns accelerate discovery field health, care, education, research, scholarly endeavors.

Язык: Английский

Процитировано

1
Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications DOI Creative Commons
Talha Bin Emran, Taslima Akter Eva,

Mehrukh Zehravi

и другие.

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(8), С. 3236 - 3256

Опубликована: Янв. 1, 2024

Respiratory diseases are the most common and severe health complication a leading cause of death worldwide. Despite breakthroughs in diagnosis treatment, few safe effective therapeutics have been reported. Phytochemicals gaining popularity due to their beneficial effects low toxicity. Polyphenols secondary metabolites with high molecular weights found at levels natural food sources such as fruits, vegetables, grains, citrus seeds. Over recent decades, polyphenols on human subject intense research, notable successes preventing major chronic non-communicable diseases. Many respiratory syndromes can be treated effectively polyphenolic supplements, including acute lung damage, pulmonary fibrosis, asthma, hypertension, cancer. This review summarizes role conditions sufficient experimental data, highlights for each, identifies those therapeutic potential underlying mechanisms. Moreover, clinical studies future research opportunities this area discussed.

Язык: Английский

Процитировано

1
The activation of cGAS‐STING pathway causes abnormal uterine receptivity in aged mice DOI Creative Commons

Si‐Ting Chen,

Wenwen Shi,

Feng Ran

и другие.

Aging Cell, Год журнала: 2024, Номер 23(11)

Опубликована: Авг. 7, 2024

Maternal age is one of the most important factors affecting success maternal pregnancy. Uterine aging leading cause pregnancy failure in older women. However, how uterine affects receptivity and decidualization unclear. In this study, naturally aged one-year-old female mice were used to investigate effects on embryo implantation during early our we found abnormal mice. Aged mouse uterus indicates a decrease nuclear LAMIN A, an increase PRELAMIN A PROGERIN. uterus, double-stranded DNA (dsDNA) cytoplasmic fraction significantly increased. PROGERIN overexpression epithelial cells organoids leads leakage impaired receptivity. DNase I, II, TREX1 are obviously reduced uterus. Treatments with foreign or STING agonist downregulate markers activate cGAS-STING pathway. estrogen (E

Язык: Английский

Процитировано

1