Immuno,
Год журнала:
2024,
Номер
4(3), С. 247 - 265
Опубликована: Авг. 21, 2024
The
planar
cell
polarity
(PCP)
of
epithelial
ciliated
cells
is
essential
for
effective
mucociliary
clearance
(MCC)
in
the
sinonasal
mucosa.
We
hypothesize
that
MCC
coordination
impaired
nasal
polyp
(NP)
mucosae
due
to
suppressed
expression
a
series
CPLANE
(ciliogenesis
and
effector)
complex
proteins
chronic
rhinosinusitis
(CRS)
patients.
To
investigate
this
hypothesis,
we
subjected
mucosal
samples
live
video
recording
measure
transport
velocity
(MCTV)
scanning
electron
microscopy
evaluate
surface
morphology.
distribution
panel
PCP
proteins,
e.g.,
WDPCP
FUZ,
were
investigated
relation
inflammatory
cytokine
levels
clinical
features.
mean
MCTV
NP
was
significantly
lower
than
inferior
turbinate
mucosae.
CRS
group
with
NPs
(CRSwNP
group)
(n
=
28)
showed
increased
IL-13
CCL26
mRNA
compared
patients
without
25)
controls
30).
FUZ
decreased
ethmoid
sinus
CRSwNP
protein
reduced
cytoplasmic
region
conclude
suppression
responsible
polyps
type-2
inflammation.
This
mechanism
might
explain
potential
worsening
symptoms
CRSwNP.
All
data
are
available
in
the
main
text
or
Data
S1.
Please
note:
The
publisher
is
not
responsible
for
content
functionality
of
any
supporting
information
supplied
by
authors.
Any
queries
(other
than
missing
content)
should
be
directed
to
corresponding
author
article.
Abstract
The
incidence
of
allergic
diseases
has
been
rising
over
the
past
decades,
and
this
troubling
trend
coincides
with
environmental
changes
such
as
shifts
in
diet
increased
antibiotic
use,
both
which
can
impact
our
immune
system.
Allergic
reactions
occur
when
system
overreacts
to
normally
harmless
substances,
it
is
known
that
regulatory
T
cells
(Tregs)
play
a
major
role
suppression
generation
tolerance.
However,
new
research
suggests
Tregs
malfunction
environments
promote
allergies.
This
review
delves
into
Treg
function,
how
factors
influence
their
ability
maintain
homeostasis.
Specifically,
we
explore
origins
cells,
well
mechanisms
used
for
inflammation
tissue
healing,
concentration
on
food
allergies,
atopic
dermatitis
asthma.
Understanding
function
context
changing
environment
crucial
developing
strategies
prevent
treat
International Forum of Allergy & Rhinology,
Год журнала:
2024,
Номер
14(8), С. 1350 - 1362
Опубликована: Июнь 30, 2024
A
chronic
condition
that
significantly
reduces
a
child's
quality
of
life
is
allergic
rhinitis
(AR).
The
environment
and
allergens
the
body
regularly
exposed
to
can
cause
inflammatory
immunological
reactions,
which
change
expression
certain
genes
Epigenetic
changes
are
closely
linked
onset
severity
allergy
disorders
according
mounting
amounts
data.
Noncoding
RNAs
(ncRNAs)
group
RNA
molecules
cannot
be
converted
into
polypeptides.
three
main
categories
ncRNAs
include
microRNAs
(miRNAs),
long
noncoding
(lncRNAs),
circular
(circRNAs).
NcRNAs
play
crucial
role
in
controlling
gene
contribute
development
numerous
human
diseases.
Immuno,
Год журнала:
2024,
Номер
4(3), С. 247 - 265
Опубликована: Авг. 21, 2024
The
planar
cell
polarity
(PCP)
of
epithelial
ciliated
cells
is
essential
for
effective
mucociliary
clearance
(MCC)
in
the
sinonasal
mucosa.
We
hypothesize
that
MCC
coordination
impaired
nasal
polyp
(NP)
mucosae
due
to
suppressed
expression
a
series
CPLANE
(ciliogenesis
and
effector)
complex
proteins
chronic
rhinosinusitis
(CRS)
patients.
To
investigate
this
hypothesis,
we
subjected
mucosal
samples
live
video
recording
measure
transport
velocity
(MCTV)
scanning
electron
microscopy
evaluate
surface
morphology.
distribution
panel
PCP
proteins,
e.g.,
WDPCP
FUZ,
were
investigated
relation
inflammatory
cytokine
levels
clinical
features.
mean
MCTV
NP
was
significantly
lower
than
inferior
turbinate
mucosae.
CRS
group
with
NPs
(CRSwNP
group)
(n
=
28)
showed
increased
IL-13
CCL26
mRNA
compared
patients
without
25)
controls
30).
FUZ
decreased
ethmoid
sinus
CRSwNP
protein
reduced
cytoplasmic
region
conclude
suppression
responsible
polyps
type-2
inflammation.
This
mechanism
might
explain
potential
worsening
symptoms
CRSwNP.
