Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
291, С. 117828 - 117828
Опубликована: Фев. 1, 2025
Microplastics
pollution
has
raised
a
considerable
awareness
due
to
their
extensive
distribution
in
the
environment.
It
potential
side
effects
on
human
health.
can
enter
respiratory
system,
then
deposit
lung,
destroying
structure
of
bronchus
and
alveoli,
causing
pulmonary
inflammation,
mucus
production,
airway
hyperresponsiveness,
leading
aggravation
asthma.
Nevertheless,
underlying
mechanism
remains
elusive.
There
are
several
cytokines
involved
inflammatory
response
Heat
shock
protein
90α(HSP90α)
is
one
involving
inflammation
which
member
HSPs
family.
The
aim
this
study
explore
by
microplastics
influence
secretion
HSP90α
progression
Initially,
we
found
that
were
destroyed
epithelial
barrier,
resulting
inherent
dysfunction
HSP90α.
Then,
proved
activate
PI3K-Akt-mTOR
pathway
prompting
cells
secrete
proliferation
smooth
muscle
cells(ASMCs),
narrowing
hypersensitivity.
1G6-D7
monoclonal
antibody
HSP90,
reverse
infiltration,
hyperresponsiveness(AHR).
Overall,
these
finding
suggested
elicited
via
signaling
stimulated
ASMCs.
Hence,
present
unveils
novel
responsible
for
microplastic-induced
hyperreactivity,
establishing
basis
further
research
risk
evaluations
microplastics.
Язык: Английский
Immunity, Inflammation and Airway Dysfunction in Elite Cross‐Country Skiers and Ice Hockey Players: A Systematic Review
Scandinavian Journal of Medicine and Science in Sports,
Год журнала:
2025,
Номер
35(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Strenuous
exercise
in
elite
sports
impacts
the
immune
system,
leading
to
high
rates
of
upper
respiratory
tract
infections
and
airway
dysfunction,
such
as
asthma
exercise‐induced
bronchoconstriction
(EIB).
Cross‐country
(XC)
skiers
ice
hockey
(IH)
players
are
particularly
affected
due
their
training
environments
disciplines.
This
systematic
review
(SR)
evaluates
inflammatory
responses
risk
developing
dysfunction
these
athletes.
Original
articles
focusing
on
response,
systemic
inflammation,
competitive
XC
IH
were
retrieved
from
MEDLINE/Ovid,
EMBASE,
Cochrane
Library.
Risk
bias
was
assessed
using
Bias
Tool.
Of
3582
studies
screened,
50
met
inclusion
criteria.
Both
exhibit
increased
cortisol
levels
altered
cell
compositions
response
competition.
groups
show
neutrophilic
or
mixed
neutrophilic/eosinophilic
contrast
primarily
eosinophilic
inflammation
associated
with
allergic
asthma.
(27%)
(14%)
had
a
prevalence
physician‐diagnosed
SR
highlights
notable
burden
winter
athletes,
elevated
EIB.
The
observed
patterns
support
concept
“sport
asthma”
endotype,
which
may
be
result
chronic
exposure
cold,
dry
air.
Effective
management
benefit
refined
diagnostic
criteria,
identification
specific
biomarkers,
tailored
prevention
treatment
strategies
for
Язык: Английский
Epithelial barrier dysfunction, type 2 immune response, and the development of chronic inflammatory diseases
Current Opinion in Immunology,
Год журнала:
2024,
Номер
91, С. 102493 - 102493
Опубликована: Сен. 24, 2024
Язык: Английский
Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs
Allergy,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 17, 2024
Abstract
Since
the
1960s,
more
than
350,000
new
chemicals
have
been
introduced
into
lives
of
humans
and
domestic
animals.
Many
them
become
part
modern
life
some
are
affecting
nature
as
pollutants.
Yet,
our
comprehension
their
potential
health
risks
for
both
animals
remains
partial.
The
“epithelial
barrier
theory”
suggests
that
genetic
predisposition
exposure
to
diverse
factors
damaging
epithelial
barriers
contribute
emergence
allergic
autoimmune
conditions.
Impaired
barriers,
microbial
dysbiosis,
tissue
inflammation
observed
in
a
high
number
mucosal
inflammatory,
neuropsychiatric
diseases,
many
which
showed
increased
prevalence
last
decades.
Pets,
especially
cats
dogs,
share
living
spaces
with
exposed
household
cleaners,
personal
care
products,
air
pollutants,
microplastics.
utilisation
cosmetic
products
food
additives
pets
is
on
rise,
unfortunately,
accompanied
by
less
rigorous
safety
regulations
those
governing
human
products.
In
this
review,
we
explore
implications
disruptions
well‐being
companion
animals,
drawing
comparisons
humans,
endeavour
elucidate
spectrum
diseases
afflict
them.
addition,
future
research
areas
interconnectedness
human,
animal,
environmental
highlighted
line
“One
Health”
concept.
Язык: Английский
Nutritional and environmental exposures in athletes: Implications on the epithelial barrier function
Allergy,
Год журнала:
2024,
Номер
79(11), С. 2909 - 2911
Опубликована: Авг. 19, 2024
Over
the
last
decades,
industrialization,
and
technological
advances
associated
with
a
modern
lifestyle
have
been
accompanied
by
an
alarming
rise
in
prevalence
of
chronic
noncommunicable
diseases.1
The
epithelial
barrier
theory
attributes
this
phenomenon
to
exposure
newly
introduced
toxic
substances
that
are
capable
disrupting
protective
barriers
since
1960s.1
Pollutants
such
as
particulate
matter,
ozone,
diesel
exhaust
particles,
nano-
and/or
micro-plastics,
surfactants,
detergents
included
cleaning
products,
or
several
additives,
emulsifiers
flavor
enhancers
used
food
industry
can
compromise
skin,
airways,
gut.1,
2
Genetic
factors
barrier-damaging
agents
promote
leaky
barriers,
leading
microbial
dysbiosis,
bacterial
translocation,
perpetuation
local
systemic
inflammation.1,
In
elegant
review
article,
Kistler
W.
et
al.
discuss
impact
hazardous
exposome
physical
exertion
typically
endured
elite
athletes.
These
may
counteract
health
benefits
regular
activity
function.
context,
experimental
evidence
supporting
be
applied
sports
medicine.3
There
is
social
scientific
consensus
on
regular,
mild
moderate
activity.
However,
epidemiological
studies
indicate
athletes
undergoing
excessive
training
not
optimal
overall
health,
which
negatively
their
sport
performance.
For
instance,
gastrointestinal
disorders
very
common
among
athletes.4
Likewise,
they
show
higher
risk
infections
noninfectious
respiratory
diseases,
exercise-induced
asthma,
rhinitis,
laryngeal
disorders.5
context
barrier,
exercise
display
J-shaped
relationship.
Moderate
improves
integrity
intestinal
turn,
promotes
growth
healthy
microbiota
populations
ameliorates
proinflammatory
immune
state.6
On
other
hand,
compelling
shows
prolonged
intense
impairs
tight
junctions,
compromising
its
allowing
entry
microbes
pollutants
trigger
inflammatory
cascade.7
some
cases,
it
also
aggravate
existing
pathology;
for
example,
gut
facilitates
passage
allergens
reduces
threshold
food-dependent
anaphylaxis.8
Similarly,
has
closely
airway
damage
inflammation,
especially
endurance
sports,
injury
key
factor
development
bronchoconstriction.9
Another
facet
highlighted
authors
at
substances.
During
exercise,
hyperpnea
increase
rate
occur
satisfy
oxygen
demands,
resulting
increased
inhalation
airborne
inflammation.10
Endurance
runners
swimmers
most
susceptible
due
high
pollution
urban
areas
chlorine-based
disinfectants
present
swimming
pools,
respectively.9,
10
nutrition
should
carefully
monitored.
Athletes
requiring
high-calorie
diet
consumption
processed
products
marketed
Sports
drinks
dietary
supplements
contain
emulsifiers,
preservatives,
enhancers,
artificial
additives
disrupt
imbalance
populations,
eventually
aggravating
well-known
symptoms
high-impact
vomiting
diarrhea.
Moreover,
important
point
out
good
hygienic
conditions
required
during
practice
athletes'
chemical
detergents,
those
clean
changing
rooms,
towels,
gear.
Altogether,
these
routines
activities
vigorous
make
more
potentially
harmful
compared
less
active
individuals.
Considering
all
above-mentioned
aspects,
conclude
call
action
necessary
implement
strategies
mitigate
environmental
burden
continuously
faced
athletes,
including
identification
avoidance
agents,
safer
discovery
novel
biomarkers
disruption,
implementation
therapeutic
approaches
based
improving
function,
further
research3
(Figure
1).
summary,
article
provides
comprehensive
potential
mechanisms
underlying
effects
theory.
reached
elevated
might
contribute
impaired
physically
Consequently,
prone
thereby
Future
research
medicine
include
deleterious
well
repair
junctions.
This
work
was
supported
grant
PID2020-114396RB-I00
O.P.
from
MICINN,
Spain.
MP-D
recipient
FPI
(SAF-20217-84978-R)
predoctoral
fellowship
Ministerio
de
Economía
y
Competitividad.
A.A.
Margarita
Salas
contract
(Reference:
UCM-CT18/22)
cofinanced
Universidades,
"Plan
Recuperación,
Transformación
Resilencia"
Complutense
University
Madrid.
Dr.
Oscar
Palomares
declares
grants
MINECO,
Ciencia
e
Innovación,
CAM,
Inmunotek
S.L.,
Novartis,
AstraZeneca
receiving
fees
presenting
lectures
participation
advisory
boards
AstraZeneca,
Pfizer,
GlaxoSmithKline,
S.L,
Novartis
Sanofi-Genzyme.
Data
sharing
applicable
no
datasets
were
generated
analysed
current
study.
Язык: Английский
One health: the impact of environment, detergents and hygiene on barrier, microbiome and allergy
Allergo Journal International,
Год журнала:
2024,
Номер
33(7), С. 252 - 262
Опубликована: Окт. 9, 2024
Summary
A
variety
of
body
surfaces,
such
as
skin
and
mucosal
membranes—from
the
nasopharyngeal
area
to
lungs,
uterus,
vaginal
area,
digestive
tract—contain
complex
microbial
ecosystems
that
are
tailored
specifics
respective
niche
[1].
The
so-called
dysbiosis—a
disadvantageous
change
in
composition
microbiome—is
associated
with
pathogenesis
a
diseases
[2].
Gastrointestinal
well
cardiovascular,
metabolic,
neurodegenerative,
psychological,
oncological,
also
allergic
have
been
linked
dysbiosis.
Susceptibility
allergies
can
be
due
genetic
predisposition;
addition,
extrinsic
factors
from
today’s
lifestyle
increasingly
contribute
microbiome
changes,
but
disruption
barrier
thus
development
[3].
Gisela,
fictional
farmer,
guides
us
through
this
review.
She
is
representative
adults
children
all
genders
industrialized
countries.
During
her
daily
routine,
influenced
by
exogenous
factors.
These
include
everyday
personal
hygiene
products,
detergents
for
laundry
dishes,
food,
medication,
animal
contact,
exposure
various
outdoor
environments.
Gisela’s
routine
will
illustrate
how
human
modified
positive
or
negative
ways,
could
influence
allergies.
Furthermore,
potential
measures
prevention
management
dysbiosis
discussed
terms
examples
alternative
products
behaviors.
Язык: Английский
One health: der Einfluss von Umwelt, Detergenzien und Hygiene auf Barriere, Mikrobiom und Allergie
Allergo Journal,
Год журнала:
2024,
Номер
33(7), С. 22 - 33
Опубликована: Окт. 31, 2024
Microplastic Exposure Induces Hsp90α Secretion And Aggravates Asthmatic Airway Remodeling Via Pi3k-Akt-Mtor Pathway
Опубликована: Янв. 1, 2024
Язык: Английский
Nutritional Dermatology: Optimizing Dietary Choices for Skin Health
Nutrients,
Год журнала:
2024,
Номер
17(1), С. 60 - 60
Опубликована: Дек. 27, 2024
Background/Objectives:
Youthful,
smooth
skin
is
highly
desired
in
modern
society.
Individuals
invest
cosmetics,
plastic
surgeons,
and
dermatologists
pursuit
of
perfect
skin.
However,
many
do
not
seek
out
dietary
changes
to
improve
health.
Although
research
has
been
conducted
on
the
role
nutrition
select
nutrients
phytonutrients
health,
there
a
lack
healthy
food
recommendations
for
clear
Methods:
The
literature
was
assessed
determine
which
play
significant
protection
maintenance
Key
compounds
were
highlighted
as
evidence
suggest
they
have
health:
vitamin
A,
C,
D,
E,
zinc,
omega-6
omega-3
fatty
acids,
polyphenols/flavonoids,
copper,
selenium,
silicon.
USDA
FoodData
Central
FooDB
(food
database),
utilized
foods
groups
containing
key
phytonutrients.
Results:
A
skin-healthy
pattern
proposed
addition
scoring
system
assess
diet.
sample
daily
diet
designed,
using
only
whole
foods,
that
met
Daily
Values
vitamins
minerals
contained
Conclusions:
There
link
between
or
nutritional
dermatology;
however,
more
needs
be
done
find
intersection
both
disciplines.
Язык: Английский