How type‐2 dendritic cells induce Th2 differentiation: Instruction, repression, or fostering T cell‐T cell communication? DOI Creative Commons
Franca Ronchese, Greta R. Webb, Sotaro Ochiai

и другие.

Allergy, Год журнала: 2024, Номер 80(2), С. 395 - 407

Опубликована: Сен. 26, 2024

Allergic disease is caused by the activation of allergen-specific CD4+ type-2 T follicular helper cells (Tfh2) and 2 (Th2) effector that secrete cytokines IL-4, IL-5, IL-9, IL-13 upon allergen encounter, thereby inducing IgE production B tissue inflammation. While it accepted priming differentiation naïve into Th2 requires presentation type dendritic (DC2s), underlying signals remain unidentified. In this review we focus on interaction between allergen-presenting DC2s in lymph node (LN), potential mechanisms which might instruct differentiation. We outline recent advances characterizing DC2 development heterogeneity. sensing current proposed differentiation, with specific consideration role how they contribute to each mechanism. Finally, assess publications reporting a detailed analysis DC-T cell interactions LNs support Together, these studies are starting shape our understanding key initial step allergic immune response.

Язык: Английский

How type‐2 dendritic cells induce Th2 differentiation: Instruction, repression, or fostering T cell‐T cell communication? DOI Creative Commons
Franca Ronchese, Greta R. Webb, Sotaro Ochiai

и другие.

Allergy, Год журнала: 2024, Номер 80(2), С. 395 - 407

Опубликована: Сен. 26, 2024

Allergic disease is caused by the activation of allergen-specific CD4+ type-2 T follicular helper cells (Tfh2) and 2 (Th2) effector that secrete cytokines IL-4, IL-5, IL-9, IL-13 upon allergen encounter, thereby inducing IgE production B tissue inflammation. While it accepted priming differentiation naïve into Th2 requires presentation type dendritic (DC2s), underlying signals remain unidentified. In this review we focus on interaction between allergen-presenting DC2s in lymph node (LN), potential mechanisms which might instruct differentiation. We outline recent advances characterizing DC2 development heterogeneity. sensing current proposed differentiation, with specific consideration role how they contribute to each mechanism. Finally, assess publications reporting a detailed analysis DC-T cell interactions LNs support Together, these studies are starting shape our understanding key initial step allergic immune response.

Язык: Английский

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