New approaches in childhood IgE-mediated food allergy treatment

Current Opinion in Allergy and Clinical Immunology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Purpose of review This aims to provide an overview the current and future treatment options for children with food allergies (FAs), highlighting latest research findings potential impact these new approaches on improving patients’ caregivers’ quality life. Recent In last decade, many promising have emerged as alternative standard avoidance culprit risk severe accidental reactions. Desensitization through oral immunotherapy has been introduced in clinical settings a therapeutic approach, more recently also omalizumab. addition, routes administration immunotherapy, other biologics, small molecules, probiotics or prebiotics, microbiota transplantation therapy, IGNX001, PVX108 are being investigated. Summary The portfolio available is increasing but several relevant unmet needs remain. brief existing IgE-mediated allergies.

Язык: Английский

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Evaluation of the Cow’s Milk and Hen’s Egg Ladder in Daily Practice: A Parent Perspective

Klinische Pädiatrie, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract Evaluation of the cow’s milk (CM) and hen’s egg (HE) ladder to improve medical care children with CM and/or HE allergy. Through an anonymous retrospective online questionnaire, we investigated parent perspectives regarding therapy option a in Of 54 families contacted, 29 took part study. 19/29 had already completed ladders when survey place. showed allergic reaction during treatment whom 17 presented skin rashes. 16/29 parents were anxious rise next step protocol. 15/29 difficulties implementation due child refusing offered food organizational issues. Medical support as well scored satisfactory. The participating satisfied care. We identified two main areas for improvement: First, suggested every should be more diverse, according families’ culture background nutritional needs/demands. Second, reduce anxiety therapy, must informed that although reactions are common, they remain mild. Furthermore, will suggest changes under supervision, especially slow progression ladder. With these improvements, duration could shortened, thus reducing risk reaction, need by allergist therefore healthcare costs.

Язык: Английский

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Generic Health‐Related Quality of Life of Children With Severe Peanut or Tree Nut Allergy

Acta Paediatrica, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

ABSTRACT Aim Food allergies may decrease health‐related quality of life. We assessed life in Finnish children at risk a severe peanut or tree nut allergy and their parents. Methods Study included aged 3–15 years referred to Tampere University Hospital for suspected allergy. Eligibility criteria history anaphylaxis and/or molecular immunology testing referring Health‐related was with generic questionnaires 15D adults, 16D teenagers 17D children, scores compared age group‐matched population references. Results A total 101 (mean 7.7 ± 2.9 years) parent pairs were enrolled. The mean score 11 12–15 parents similar reference populations; parental distress borderline statistically worse (0.890 vs. 0.932, p = 0.013). 90 3–11 significantly higher (0.959 0.938) than references ( < 0.01). Conclusion Children had comparable the population. Distress among seemed be increased, warranting more focus on counselling.

Язык: Английский

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Predicting Tolerance to Cow’s Milk Allergy in Children Using IgE and IgG4 Peptide Binding Profiles

Cells, Год журнала: 2025, Номер 14(5), С. 344 - 344

Опубликована: Фев. 27, 2025

Cow's milk allergy (CMA) is the most common food in infants. This study aimed to identify peptide biomarkers predictive of tolerance a Spanish population children with CMA. We investigated specific IgE and IgG4 binding sequential epitopes five major CM allergens (α-s1-, α-s2-, β-, κ-caseins as well β-lactoglobulin) using microarray-based immunoassay. Microarray analysis was performed 118 patients at baseline after 6, 18, 30, 42, 54 months. Most tolerated 6 months (40.7%) 18 (35.4%). found significant differences intensity diversity between allergic tolerant patients. No were observed baseline. Combining serology variables microarray results, model developed XGBoost algorithm classify status different time points. The generated models showed high value 30 AUCs 0.883 0.833, respectively. Therefore, antibody-binding peptides baseline, we two predicting cow's

Язык: Английский

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Sinnvolle Diagnostik bei Verdacht auf Allergien

Monatsschrift Kinderheilkunde, Год журнала: 2025, Номер 173(3), С. 196 - 208

Опубликована: Март 1, 2025

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Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-allergic Children with Atopic Comorbidities

Annals of Allergy Asthma & Immunology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Basophil Activation and Histamine Release Tests in Relation to Omalizumab Response in Peanut‐Allergic Children

Clinical & Experimental Allergy, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

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Editorial comment on “When I became older, I started having to manage that more myself”—Experiences of adolescents with food allergies: A qualitative study

Pediatric Allergy and Immunology, Год журнала: 2025, Номер 36(4)

Опубликована: Апрель 1, 2025

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Язык: Английский

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Oral Immunotherapy with Standardized Peanut Extract: A Game-Changer for Peanut Allergy

Applied Sciences, Год журнала: 2025, Номер 15(9), С. 4833 - 4833

Опубликована: Апрель 27, 2025

Peanut allergy is a persistent and potentially life-threatening condition affecting millions worldwide, necessitating effective therapeutic strategies beyond strict avoidance. Oral immunotherapy (OIT) has emerged as promising approach, with peanut (Arachis hypogaea) allergen powder dnfp (Palforzia Aimmune therapeutics Brisbane Calif]) being the first FDA-approved standardized OIT for allergy. This review synthesizes current clinical evidence on PTAH (peanut-tolerant Arachis hypogea), focusing its efficacy, safety, long-term outcomes. A systematic literature search was conducted, analyzing key phase 3 trials, including PALISADE, ARTEMIS, POSEIDON, well extension studies such ARC004 ARC008. Findings indicate that significantly increases protein threshold tolerated by allergic individuals, reducing risk of severe reactions upon accidental exposure. While adverse events gastrointestinal symptoms anaphylaxis occur, they are generally manageable decline over time continued therapy. Notably, younger children in POSEIDON trial exhibited higher desensitization rates, suggesting potential benefits early intervention. Long-term demonstrate sustained immune modulation, reductions peanut-specific IgE an increase IgG4, indicative developing tolerance. Despite limitations adherence challenges need ongoing maintenance dosing, represents paradigm shift management, offering improved safety quality life patients caregivers.

Язык: Английский

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Improving Safety in Food Allergen-Specific Oral Immunotherapy

Applied Sciences, Год журнала: 2025, Номер 15(9), С. 4857 - 4857

Опубликована: Апрель 27, 2025

Food allergies are becoming more common globally. The strict elimination diet, as the main approach so far, has a negative impact on different areas of lives children suffering from food allergies, well their caregivers. Oral immunotherapy (OIT), which consists ingesting small, gradually increasing amounts allergens, is promising approach. Although efficient, this accompanied by frequent adverse reactions (AR), some severe anaphylaxis. It seems that, generally, slow dose escalation, low maintenance doses with longer durations, make OIT safer, especially in allergies. Furthermore, less allergenic forms such baked milk or egg, also contribute to safety. Adjuvant therapy combination potential improve efficiency and Treatment monoclonal antibodies omalizumab dupilumab promising. While both could efficiency, have better effect Interferon γ shows results. In contrast, probiotics vitamin D supplementation still controversial, new trials about synergistic needed.

Язык: Английский

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