Immunological Reviews, Год журнала: 2025, Номер 331(1)
Опубликована: Май 1, 2025
ABSTRACT Immunoglobulin E (IgE) plays a dual role in the immune system, providing protection against pathogens while also mediating pathological hypersensitivity reactions. Its function is mainly studied context of immediate inflammatory responses, where IgE‐sensitized effector cells, such as mast cells and basophils, are triggered by cross‐linking antigen. An often‐overlooked feature IgE biology its strong ability to boost secondary adaptive thus acting physiological adjuvant. The regulation these responses influenced various factors, including primary Ig structure, post‐translational modifications glycosylations, structural properties antigens, interaction with receptors. Interestingly, not only generates antigen‐specific but IgE‐specific autoimmune responses. Natural IgG anti‐IgE autoantibodies circulate at surprisingly high levels, even healthy individuals, contributing serum levels Understanding emerging concepts, beyond singular focus on initial production cell activation, could contribute better understanding immunological functions IgE. In this review, we aim provide an overview current knowledge immunogenicity. Many open questions remain negative positive feedback mechanisms which regulates response, hope inspire future research into underlying IgE‐regulated their potential implications for therapeutic strategies diseases.
Язык: Английский